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51.
4,4-Disubstituted Imidazole Derivatives from the Reaction of 3-Amino-2H-azirines with Salicylamide Reaction of 3-amino-2H-azirines 1a–c with salicylamide ( 7 ) in MeCN leads to imidazoles 10 and 11 in different rates, depending on the conditions. In the case of 1a and 1b, 11a and 11b , respectively, have been obtained as the main product at 50°; in reactions at 80°, 10a and 10b are the favored products (Tables 1 and 2). 2,2-Dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine ( 1c ) reacts with 7 in MeCN mainly to 2-(2-hydroxyphenyl)-5,5-dimethyl-3,5-dihydroimidazol-4-one ( 10a ); in boiling toluene, 11c is formed with low preference (Table 3). The structure of the products has been established by spectroscopic means, and in the case of 10b and 11c , by X-ray crystallography. Two different reaction mechanisms for the formation of the products are discussed (Scheme 2). 相似文献
52.
53.
Reaction of the triolide 1 from (R)-3-hydroxybutanoic acid with Lawesson's reagent 5 leads to the mono-, di-, and trithio derivatives 6–8 which can be isolated in pure form (20–40% yields), and which have crystal structures very similar to the parent triolide 1 (Fig. 1). Similarly, pentolide 3 is converted to mixtures of various thio derivatives, three of which are separated ( 10–12 ) by HPLC and fully characterized. The X-ray structures of the mono- and of one of the dithiopentolides ( 10, 12 ) differ remarkably from each other (Fig. 3). Reduction of the thiotriolides 6–8 (NaBH4, R3SnH, Cl3SiH, Raney-Ni) gives 12-membered rings containing up to three ether groups (chiral crown ethers, 15, 17–19 ) in poor yields. The thiotriolides react spontaneously and in yields of up to 96% with ammonia, certain primary amines, and hydroxylamine to give imine and oxime derivatives with intact 12-membered-ring backbones ( 20, 22–24, 30 , see crystal structures in Figs. 4–7). The rigid structure of all the derivatives of triolide 1 puts the C?O, C?S, and C?NR O-, S-, and N-atoms in juxtaposition (a feature reminiscent of the side chains in the iron-binder enterobactin, Fig. 6). Imines containing PPh2 groups are prepared ( 30, 33, 35 ) from the thiotriolides and tested as chiral ligands for PdII-catalyzed 1,3-diphenyallylations (→ 37 , enantiomer ratio up to 77:23). The reactions described demonstrate that multiple reactions of the triolide 1 from (R)-3-hydroxybutanoic acid which proceed through tetrahedral intermediates are possible without ring opening – the skeleton is remarkably stable, and this might be exploited as a template for bringing up to three pendent substituents into close proximity to allow a study of their interactions and cooperative properties. Also, the di- and trithio derivatives 7 and 8 could be used for cross-linking in molecules containing primary NH2 groups. 相似文献
54.
Summary Diphenyl(2-pyridyl)phosphine (PPh2pyl), phenylbis(2-pyridyl)-phosphine (PPhpyl2) and tris(2-pyridyl)-phosphine (Ppyl3) react with [Rh(acac)(CO)2] (acac=acetylacetonate) and Rh(8-oxy)(CO)2(8-oxy=8-hydroxyquinolinate) yielding [Rh(chel)(CO)(PPhxpyl3–x)]. The properties of these complexes were examined by spectral (i.r.,u.v.-vis,31P n.m.r.) and chemical methods. 相似文献
55.
Florian Bentivegna Michael Canva Alain Brun Frédéric Chaput Jean-Pierre Boilot 《Journal of Sol-Gel Science and Technology》1997,9(1):33-39
We study herein the rotational mobility of organic dye molecules and their ability to align on a strong optical electric field when they are encaged in the pores of an inorganic silica xerogel matrix. We compare the case of dye molecules simply dispersed in the pores of the gel—and possibly held by hydrogen bonds—to the case of molecules chemically grafted on the inner surface of these pores through covalent bonds. The study is led on hybrid silicon-zirconium based inorganic matrices doped with organic rhodamine B molecules. The stronger holding of the dopants when these are grafted to the matrix enhances the molecular alignment—and thus the induced anisotropy—as well as the remanence of this alignment. Furthermore, we show that submitting the samples to a supplementary drying at higher temperature tends to increase both the alignment anisotropy and its stability. We explain these results in terms of mobility of the molecules, in relation to their immediate environment. 相似文献
56.
Using intermolecular SCF-perturbation theory, the controlling factors determining the regioselectivity in the acrolein dimerization are derived by a rigorous decomposition of the interaction energy. This partitioning of the interaction energy is performed up to a level where a comparison with frontier orbital models is possible. The regioselectivity is found to be determined by orbital interactions occuring via the terminal atoms and atoms involved in secondary Woodward-Hoffmann interactions. 相似文献
57.
Franz Gölles 《Mikrochimica acta》1960,48(3):429-447
Zusammenfassung
Fischers Methode der Mikrountersuchung der kritischen Mischungs-temperatur hat grundsätzlich neue Wege in der Analyse binärer und ternärer Flüssigkeitsgemische eröffnet.In dieser Arbeit wurde versucht, für die homologe Reihe: Oxalsäure-Malonsäure-Bernsteinsäure durch Ermittlung der Mischungslückendiagramme Zusammenhänge zwischen den beim sogenannten 'Makroversuch und den bei der Mikrobestimmung auf dem Kofler-Heiztisch herrschenden Verhältnissen aufzuzeigen und gleichzeitig eine brauchbare Schnellmethode für die Bestimmung wässeriger Lösungen der untersuchten Säuren zu finden.Weiters wurden die Unterschiede, die sich zwischen den Maximalwerten der Mischungslückendiagramme, ihren volumgleichen Temperaturwerten und den Werten der auf dem Heiztisch gefundenen Mikroeichkurve experimentell erfaßt und diskutiert.Es sei besonders im Falle der Oxalsäure auf die obgenannten Unterschiede hingewiesen. Im Schaubild sieht man die Eichkurve nachFischer als Gerade, um die herum sich die Werte der Maxima und die volumgleichen Werte sozusagen als 'periodische Funktionen legen. Diese Werte sind also nicht immer eindeutige Funktionen der Konzentration der betreffenden Lösung. Die Temperaturwerte des Mischungsverhältnisses 50 50 (die ja für die Aufstellung analytisch brauchbarer Eichkurven überhaupt als einzige in Betracht kämen) wurden übrigens bei der Anilinpunktbestimmung zur Prüfung von Kraftstoffen praktisch verwertet13. Die Mikrobestimmung in der Kapillare ist wegen der an anderer Stelle besprochenen Vorzüge jedem Makroverfahren überlegen.
Summary Fischer's method of micro investigation of the critical mixing temperature has revealed completely new ways in the analysis of binary and ternary mixtures of liquids.By determining the miscibility gap diagram, attempts were made to discover the connections between the so-called macro-trial and the microdetermination using the Kofler heating stage, and at the same time to discover a rapid method for determining aqueous solutions of the acids under investigation, which belonged to the homologous series: oxalic, malonic, succinic acids.Furthermore, the differences which were found between the maximal values of the miscibility gap diagram, their volume-equal temperature values, and the values of the micro calibration curve found on the heated stage were discussed.Special emphasis is given to these differences in the case of oxalic acid. In the diagram, the calibration curve afterFischer appears as a straight line about which are situated the values of the maxima and the volume-equal values so-to-say as periodic functions. These values are not always therefore unequivocal functions of the concentration of the solution in question. The temperature values of the miscibility ratios (5050), which in fact are the only ones that could be considered in the construction of analytically usable calibration curves, were also evaluated in practice in the determination of the aniline point for testing motor fuels13. Because of the advantages discussed elsewhere, the micro determination in a capillary is superior to any macro method.
Résumé La méthode deFischer de microdéterminations de la température critique de mélange a ouvert de nouvelles voies fondamentales à l'analyse des mélanges liquides binaires et ternaires.Dans le travail présenté l'auteur cherche à montrer, pour la série homologue acide oxalique, acide malonique, acide succinique, par l'établissement des diagrammes de discontinuité des mélanges, les relations existant entre les conditions de la «macrodétermination» et celles de le microdétermination avec le banc chauffant de Kofler; simultanément il s'efforce de mettre au point une méthode rapide de dosage des solutions aqueuses des acides considérés.Par ailleurs il a mis en évidence et discuté les différences qui se manifestent expérimentalement entre, d'une part, les valeurs maxima des diagrammes de discontinuité des mélanges et les valeurs des températures à volume constant et d'autre part les valeurs trouvées pour la courbe de micro étalonnage sur banc chauffant.L'auteur a particulièrement étudié ces différences dans le cas de l'acide oxalique. Sur la figure on voit que la courbe d'étalonnage d'aprèsFischer est une droite tandis que les valeurs des maxima et les valeurs des températures à volume constant se présentent comme des fonctions «périodiques». Il en résulte que ces valeurs ne sont pas toujours des fonctions univoques de la concentration de la solution considérée. Les valeurs de la température pour le rapport de mélange 50/50 (qui pour l'établissement de courbes d'étalonnage utilisables en analyse doivent être exclusivement frites en considération) ont été en outre pratiquement utilisées pour le contrôle de la détermination du point d'aniline de carburants13. La microdétermination en capillaire, du fait d'avantages qui sont décrits dans une autre publication, est supérieure à toute macro-technique.相似文献
58.
Stephen T. Ross Robert G. Franz James W. Wilson Richard A. Hahn Henry M. Sarau 《Journal of heterocyclic chemistry》1986,23(6):1805-1814
The three possible mono-O-methyl derivatives of 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepin-7,8-diol (SK&F 82526) ( 1 ) have been synthesized to facilitate the isolation and characterization of metabolites of this compound and for biological testing. The syntheses generally involved preparation of appropriately substituted benzaldehydes, conversion of these to phenylacetic acids and use of these to N-acylate arylethanolamines. The phenylacetamides thus formed were reduced to amines and these were deprotected and cyclized to the desired final products. In one case deprotection followed cyclization. These compounds were tested as activators of dopamine-sensitive adenylate cyclase (a measure of DA-1 agonist activity) and as renal vasodilators. All three O-methyl derivatives were much less potent than 1 in cyclase activation and as renal vasodilators. Weak inhibition of adenyl cyclase was also observed for all three compounds and one showed weak renal vasoconstrictor activity. Preliminary investigation of the metabolism of 1 disclosed that two of the three monomethoxy compounds were formed in trace amounts in the rat and the dog. In a related investigation, the trimethoxy derivative of 1 was subjected to acid-catalyzed hydrolysis conditions. The relative ease of cleavage of methoxy groups was 7 > > 4′ > 8. 相似文献
59.
We report on the efficiency behavior of light-emitting electrochemical cells (LECs) fabricated from a methyl-substituted ladder-type poly(p-phenylene) (mLPPP) that was blended with a crown ether based solid state electrolyte. Unlike organic light-emitting diodes (oLEDs) utilizing mLPPP as an active layer, the LECs suffer from a loss of efficiency at elevated current densities. From scan rate dependent studies we deduce that this efficiency drop is not only due to device decomposition upon high voltage operation and we also reveal the intrinsic mode of LEC operation. The decreasing width of the intrinsic region between the p- and n-type doped zones upon ongoing pin-junction formation causes distinct (either field or electrode induced) luminance quenching effects. 相似文献
60.
Cantat T Jaroschik F Nief F Ricard L Mézailles N Le Floch P 《Chemical communications (Cambridge, England)》2005,(41):5178-5180
New samarium carbene complexes have been synthesized and characterized by X-ray diffraction analysis; the carbenic nature was assessed by reactivity studies. 相似文献