A homogenized viscoelastic model for masonry structures

A linear viscous model for evaluating the stresses and strains produced in masonry structures over time is presented. The model is based on rigorous homogenization procedures and the following two assumptions: that the structure is composed of either rigid or elastic blocks, and that the mortar is viscoelastic. The hypothesis of rigid block is particularly suitable for historical masonry, in which stone blocks may be assumed as rigid bodies, while the hypothesis of elastic blocks may be assumed for newly constructed brickwork structures. The hypothesis of viscoelastic mortar is based on the observation that non-linear phenomena may be concentrated in mortar joints. Under these assumptions, constitutive homogenized viscous functions are obtained in an analytical form.Some meaningful cases are discussed: masonry columns subject to minor and major eccentricity, and a masonry panel subject to both horizontal and vertical loads. The major eccentricity case is analysed taking into account both the effect of viscosity and the no-tension hypothesis, whereas the bi-dimensional loading case is analysed to verify the sensitivity of masonry behaviour to viscous function. In the masonry wall considered, the principal stresses are both of compression, and the no-tension assumption may therefore be discounted.     

A homogenized Love–Kirchhoff model for out-of-plane loaded random 2D lattices: Application to “quasi-periodic” brickwork panels

A homogenization procedure for finding the bending stiffness of a 2D regular lattice with random local interactions is proposed. The kinematic and static methods are used to provide explicit upper and lower bounds for the homogenized moduli. The proposed homogenization procedure is applied to a masonry obtained by a random perturbation of the periodic running bond masonry [Cecchi, A., Sab, K., 2009. Discrete and continuous models for in plane loaded random elastic brickwork. Eur. J. Mech. A 28, 610–625].A numerical evaluation of the scatter between the discrete models and the 2D Love–Kirchhoff model is performed on a test case, for various values of the random perturbation parameter and of the parameter that characterizes the heterogeneity of the wall. As expected, when the number of heterogeneities in the structure is large enough, the average response of the random discrete model converges to an asymptotic response. It is shown that this asymptotic response is very close to that of the periodic discrete model which is in turn very close to the response of the deterministic homogenized model. Similarly to the conclusion of Cecchi and Sab [Cecchi A., Sab K., 2009. Discrete and continuous models for in plane loaded random elastic brickwork. Eur. J. Mech. A. 28, 610–625.] dedicated to in-plane loading, the present results concerning out-of-plane loading show (both by means of a discrete model and a homogenized model) that the running bond pattern may be used successfully to analyze historical masonries with blocks having irregular widths in the horizontal direction.     

A kinematic FE limit analysis model for thick English bond masonry walls

Two-wythes masonry walls arranged in English bond texture were often used in the past as bearing panels in seismic area. On the other hand, earthquake surveys have demonstrated that masonry strength under horizontal actions is usually insufficient, causing premature collapses of masonry buildings, often ascribed to out-of-plane actions. Furthermore, many codes of practice impose for new brickwork walls a minimal slenderness, which for instance is fixed by the Italian O.P.C.M. 3431 equal to 12 for artificial bricks and 10 for natural blocks masonry.For the above reasons, the analysis at failure of English bond brickwork walls under out-of-plane actions is a topic that deserves consideration, despite the fact that almost the totality of the studies of masonry at failure is devoted to running bond arrangements. Furthermore, it must be noted that an approach based on the analysis of running bond texture – in comparison with English bond pattern – is not suitable for the investigation of the behavior of bearing panels.In this framework, in the present paper, a Reissner–Mindlin kinematic limit analysis approach is presented for the derivation of the macroscopic failure surfaces of two-wythes masonry arranged in English bond texture. In particular, the behavior of a 3D system constituted by infinitely resistant bricks connected by joints reduced to interfaces with frictional behavior and limited tensile/compressive strength is identified with a 2D Reissner–Mindlin plate. In this way, assuming both an associated flow rule for the constituent materials and a finite subclass of possible deformation modes, an upper bound approximation of macroscopic English bond masonry failure surfaces is obtained as a function of macroscopic bending moments, torsion and shear forces.Several examples of technical relevance are treated both at a cell level and at a structural level, addressing the differences in terms of collapse loads and failure surfaces due to different textures and constituent laws for joints. Finally, two meaningful structural examples consisting of a panel in cylindrical flexion and a masonry slab constrained at three edges and out-of-plane loaded are discussed. A detailed comparison in terms of deformed shapes at collapse and failure loads between a 2D FE Reissner–Mindlin limit analysis approach and a full 3D heterogeneous FE model shows the reliability of the results obtained using the kinematic identification approach proposed.     

Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX

The X-ray crystal structure of the fluorescent antitumor sulfonamide carbonic anhydrase (CA, EC, 4.2.1.1) inhibitor (4-sulfamoylphenylethyl)thioureido fluorescein (1) in complex with the cytosolic isoform hCA II is reported, together with a modeling study of the adduct of 1 with the tumor-associated isoform hCA IX. Its binding to hCA II is similar to that of other benzesulfonamides, with the ionized sulfonamide coordinated to the Zn2+ ion within the enzyme active site, and also participating in a network of hydrogen bonds with residues Thr199 and Glu106. The scaffold of 1 did not establish polar interactions within the enzyme active site but made hydrophobic contacts (<4.5 A) with Gln92, Val121, Phe131, Val135, Leu198, Thr199, Thr200, and Pro202. The substituted 3-carboxy-amino-phenyl functionality was at van der Waals distance from Phe131, Gly132, and Val135. The bulky tricyclic fluorescein moiety was located at the rim of the active site, on the protein surface, and strongly interacted with the alpha-helix formed by residues Asp130-Val135. All these interactions were preserved in the hCA IX-1 adduct, but the carbonyl moiety of the fluorescein tail of 1 participates in a strong hydrogen bond with the guanidine moiety of Arg130, an amino acid characteristic of the hCA IX active site. This may account for the roughly 2 times higher affinity of 1 for hCA IX over hCA II and may explain why in vivo the compound specifically accumulates only in hypoxic tumors overexpressing CA IX and not in the normal tissues. The compound is in clinical studies as an imaging tool for acute hypoxic tumors.     

Multielement determination in Tillandsia by INAA

Instrumental neutron activation analysis was employed to measure 43 elements, including some macroconstituents, in the leaves of some species of the epiphytic genusTillandsia (Bromeliaceae). The results, confirming the oligotrophyc nature of the genus, are briefly discussed with regard to a possible role as multielemental environmental monitors.     

Global monotonicity and oscillation for second order differential equation

Oscillatory properties of the second order nonlinear equation

Scale-free brain functional networks

Functional magnetic resonance imaging is used to extract functional networks connecting correlated human brain sites. Analysis of the resulting networks in different tasks shows that (a) the distribution of functional connections, and the probability of finding a link versus distance are both scale-free, (b) the characteristic path length is small and comparable with those of equivalent random networks, and (c) the clustering coefficient is orders of magnitude larger than those of equivalent random networks. All these properties, typical of scale-free small-world networks, reflect important functional information about brain states.     

Heavy-metal distribution in pore waters of the Cona Marsh: A preliminary investigation on surface sediments

Summary The results of an investigation about the heavy-metal distribution in pore waters of an estuarine shallow-water system (Cona Marsh, Venice Lagoon) are described. The area was sampled for surface and subsurface sediments; pore waters were extracted by centrifugation and heavy-metal concentration measured by means of PIXE technique. A high variability of heavy-metal concentration was observed in pore waters of sampled sites, as a result of physico-chemical conditions in the water sediment column, with a different spatial distribution between two groups of metals (Fe, Mn and Crvs. Cu, Ni and Zn). Concentration gradients between pore and bottom waters were evaluated in order to investigate the metal enrichment as a function of their mobility in the sediment and diagenesis phenomena. Paper presented at the IX Congresso del Gruppo Nazionale per la Fisica dell'Atmosfera e dell'Oceano, June 8–10, 1992, Rome.