Advective Transport in Heterogeneous Formations: The Impact of Spatial Anisotropy on the Breakthrough Curve

Water flow and solute transport take place in formations of spatially variable conductivity K. The logconductivity Y?= ln K is modeled as a random stationary space function, of normal univariate pdf (of mean In K _G and variance ${\sigma_{Y}^{2}}$ ) and of axisymmetric autocorrelation of integral scales I _h,I _v (anisotropy ratio f?=?I _v/I _h?<?1). The head gradient and the velocity are uniform in the mean, parallel to bedding, and of constant and given as J and U, respectively. Transport is ruled by advection, which typically overwhelms pore scale dispersion in the breakthrough curve (BTC) determination. In the present study we analyze the impact of anisotropy f on the BTC of a passive solute, which is related to the mass flux??? (t, x) at a control plane at x. While a considerable body of literature dealt with weakly heterogeneous formations ( ${\sigma _{Y}^{2} <1 }$ ), the present study addresses the case of ${\sigma _{Y}^{2} >1 }$ , which is of interest for many aquifers and is more difficult to solve either numerically or by approximations. We approach the three dimensional problem by modeling the structure as an ensemble of densely packed oblate spheroids of semi-major and semi-minor axis R and f R, respectively, and independent lognormal K, submerged in a matrix of uniform conductivity K _ef, the effective conductivity of the ensemble. The detailed numerical simulations of transport show that the BTC is insensitive to the value of the anisotropy ratio f, i.e.,??? (t, x) I _h/U depends only on ${\sigma _{Y}^{2}}$ (except for small differences in the tail). This important result implies that transport, as quantified by BTCs or spatial longitudinal mass distributions, can be modeled accurately by the much simpler solutions developed in the past for isotropic media, like e.g., the semi-analytical self-consistent approximation.     

Polymorphism of A, B and H substances in human urine

The gel-chromatographic behavior of A, B and H substances from urine was examined and compared with that of previously described AHB salivary fractions. Urinary fractions 1 and 2 exhibited a molecular size smaller than those of salivary fractions 1 and 2. In the urine of 52 subjects a polymorphism of A, B and H substances, with four main types, was observed which is independent of the salivary one and of the so-called secretor and nonsecretor status.     

Whirl and whip instabilities in rotor-bearing system considering a nonlinear force model

Linear models and synchronous response are generally adequate to describe and analyze rotors supported by hydrodynamic bearings. Hence, stiffness and damping coefficients can provide a good model for a wide range of situations. However, in some cases, this approach does not suffice to describe the dynamic behavior of the rotor-bearing system. Moreover, unstable motion occurs due to precessional orbits in the rotor-bearing system. This instability is called “oil whirl” or “oil whip”. The oil whirl phenomenon occurs when the journal bearings are lightly loaded and the shaft is whirling at a frequency close to one-half of rotor angular speed. When the angular speed of the rotor reaches approximately twice the natural frequency (first critical speed), the oil whip phenomenon occurs and remains even if the rotor angular speed increases. Its frequency and vibration mode correspond to the first critical speed. The main purpose of this paper is to validate a complete nonlinear solution to simulate the fluid-induced instability during run-up and run-down. A flexible rotor with a central disk under unbalanced excitation is modeled. A nonlinear hydrodynamic model is considered for short bearing and laminar flow. The effects of unbalance, journal-bearing parameters and rotor arrangement (vertical or horizontal) on the instability threshold are verified. The model simulations are compared with measurements at a real vertical power plant and a horizontal test rig.     

Purification of clenbuterol-like beta2-agonist drugs of new generation from bovine urine and hair by alpha1-acid glycoprotein affinity chromatography and determination by gas chromatography-mass spectrometry

The control of illegal use of clenbuterol and other β₂-agonist drugs as growth promoters in the European Union countries has led to outlaw practices for synthesizing new concept molecules, showing similar biological activity but not detectable by test methods usually employed to perform the official monitoring programmes. The synthesis schemes of some β₂-agonist compounds, formally derived from clenbuterol, were found out by Italian detective authorities. These compounds were synthesised ex novo in our laboratories: then, both their molecular structures and biological activities were characterised. In this paper, we describe different strategies for purifying some β₂-agonist drugs of new concept, more hydrophobic than clenbuterol. A two-step clean up procedure, prior to gas chromatography-mass spectrometry analysis, was developed for the multi-residue determination of these β₂-agonists from bovine hair and urine. The purification strategy we chose was based on adsorption solid phase extraction and, subsequently, on specific molecular recognition by affinity chromatography. The affinity columns were homemade by coupling bovine α₁-acid glycoprotein, a plasmatic acceptor for basic drugs, to a chromatographic support; their effectiveness for purifying new β₂-agonists was discussed. The data about method recoveries and repeatability were also reported.     

Rapid quantification of total genomic DNA methylation degree by short-end injection capillary zone electrophoresis

We propose a new capillary zone electrophoresis method applying short-end injection technique for the fast evaluation of methylcystosine/total cytosine ratio after acidic DNA hydrolysis. By short-end injection and by using a 100 mmol/l Tris solution titrated with 1 mol/l phosphoric acid to pH 3.75 as background electrolyte, cytosine and methylcytosine were separated with a good resolution in less than 1.5 min. Stepwise multiple linear regression with DNA methylation degree as the dependent variable and age, cysteine, homocysteine and methionine as independent variables, showed a negative association with age and that total cysteine is the most important determinant of DNA methylation.     

A result concerning the existence of certain finite Minkowski - 2 - Structures

Under a special assumption, a theorem concerning the order of Minkowski - 2 - Structures is proved. In particular it is shown that if is a sharply 4 - transitive set of permutations onn elements (n7, integer), such that contains the identical permutation and implies ^–1, then isn=11.     

New Vistas in Frontal Polymerization

Frontal Polymerization is a technique for the synthesis of polymers that, by exploiting the heat liberated by the self-same reaction, generates a hot front that can sustain and propagate itself from one end of the reactor to the other converting monomer into polymer. After the activation and following formation of the front, it is not necessary to provide any other form of energy in order to carry out polymerization. In this article we will summarize some of the recent results we have obtained in the application of Frontal Polymerization to the preparation of polyurethanes, unsaturated polyester resins, and polyacrylates.