全文获取类型
收费全文 | 127篇 |
免费 | 4篇 |
专业分类
化学 | 66篇 |
力学 | 1篇 |
数学 | 13篇 |
物理学 | 51篇 |
出版年
2019年 | 2篇 |
2018年 | 2篇 |
2016年 | 5篇 |
2014年 | 3篇 |
2013年 | 6篇 |
2012年 | 2篇 |
2011年 | 3篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 7篇 |
2007年 | 7篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 4篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 5篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1959年 | 3篇 |
1958年 | 2篇 |
1928年 | 1篇 |
1921年 | 1篇 |
1914年 | 1篇 |
1911年 | 1篇 |
排序方式: 共有131条查询结果,搜索用时 15 毫秒
1.
Baurin N Aboul-Ela F Barril X Davis B Drysdale M Dymock B Finch H Fromont C Richardson C Simmonite H Hubbard RE 《Journal of chemical information and computer sciences》2004,44(6):2157-2166
We have designed four generations of a low molecular weight fragment library for use in NMR-based screening against protein targets. The library initially contained 723 fragments which were selected manually from the Available Chemicals Directory. A series of in silico filters and property calculations were developed to automate the selection process, allowing a larger database of 1.79 M available compounds to be searched for a further 357 compounds that were added to the library. A kinase binding pharmacophore was then derived to select 174 kinase-focused fragments. Finally, an additional 61 fragments were selected to increase the number of different pharmacophores represented within the library. All of the fragments added to the library passed quality checks to ensure they were suitable for the screening protocol, with appropriate solubility, purity, chemical stability, and unambiguous NMR spectrum. The successive generations of libraries have been characterized through analysis of structural properties (molecular weight, lipophilicity, polar surface area, number of rotatable bonds, and hydrogen-bonding potential) and by analyzing their pharmacophoric complexity. These calculations have been used to compare the fragment libraries with a drug-like reference set of compounds and a set of molecules that bind to protein active sites. In addition, an analysis of the overall results of screening the library against the ATP binding site of two protein targets (HSP90 and CDK2) reveals different patterns of fragment binding, demonstrating that the approach can find selective compounds that discriminate between related binding sites. 相似文献
2.
3.
Wall DB Berger SJ Finch JW Cohen SA Richardson K Chapman R Drabble D Brown J Gostick D 《Electrophoresis》2002,23(18):3193-3204
Peptide mass fingerprinting by matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) is one of the standard high-throughput methods for protein identification today. Traditionally this method has been based on spotting peptide mixtures onto MALDI targets. While this method works well for more abundant proteins, low-abundance proteins mixed with high-abundance proteins tend to go undetected due to ion suppression effects, instrumental dynamic range limitations and chemical noise interference. We present an alternative approach where liquid chromatography (LC) effluent is continuously collected as linear tracks on a MALDI target. In this manner the chromatographic separation is spatially preserved on the target, which enables generation of off-line LC-MS and LC-MS/MS data by MALDI. LC-MALDI sample collection provides improved sensitivity and dynamic range, spatial resolution of peptides along the sample track, and permits peptide mass mapping of low-abundance proteins in mixtures containing high-abundance proteins. In this work, standard and ribosomal protein digests are resolved and captured using LC-MALDI sample collection and analyzed by MALDI-TOF-MS. 相似文献
4.
5.
6.
From measurement of the heat of hydrolysis, at 25°C , the enthalpy of formation of rubidium tetrafluoroiodate is derived: ΔH°f [RbIF4, cryst.]298= ?191.12±4.43 kJ mol?1. Heat capacity measurements for RbIF4 over the range 273–303 K are also reported. 相似文献
7.
8.
Abstract Introduction to Graphical Modelling by David Edwards, New York: Springer-Verlag, 1995, 274 pp. Reviewed by Garry Robins Introduction to Graphical Modelling by David Edwards, New York: Springer-Verlag, 1995, 274 pp. Reviewed by Garry Robins Graphical Models by Steffen L. Lauritzen, Oxford, U.K.: Clarendon Press, 1996, 298 pp. Reviewed by Garry Robins 相似文献
9.
S. Dooley M. P. Burke M. Chaos Y. Stein F. L. Dryer V. P. Zhukov O. Finch J. M. Simmie H. J. Curran 《国际化学动力学杂志》2010,42(9):527-549
The oxidation of methyl formate (CH3OCHO) has been studied in three experimental environments over a range of applied combustion relevant conditions:
- 1. A variable‐pressure flow reactor has been used to quantify reactant, major intermediate and product species as a function of residence time at 3 atm and 0.5% fuel concentration for oxygen/fuel stoichiometries of 0.5, 1.0, and 1.5 at 900 K, and for pyrolysis at 975 K.
- 2. Shock tube ignition delays have been determined for CH3OCHO/O2/Ar mixtures at pressures of ≈ 2.7, 5.4, and 9.2 atm and temperatures of 1275–1935 K for mixture compositions of 0.5% fuel (at equivalence ratios of 1.0, 2.0, and 0.5) and 2.5% fuel (at an equivalence ratio of 1.0).
- 3. Laminar burning velocities of outwardly propagating spherical CH3OCHO/air flames have been determined for stoichiometries ranging from 0.8–1.6, at atmospheric pressure using a pressure‐release‐type high‐pressure chamber.
10.