Computationally efficient evaluation of appointment schedules in health care

We consider the problem of evaluating and constructing appointment schedules for patients in a health care facility where a single physician treats patients in a consecutive manner, as is common for general practitioners, clinics and for outpatients in hospitals. Specifically, given a fixed-length session during which a physician sees K patients, each patient has to be given an appointment time during this session in advance. Optimising a schedule with respect to patient waiting times, physician idle times, session overtime, etc. usually requires a heuristic search method involving a huge number of repeated schedule evaluations. Hence, our aim is to obtain accurate predictions at very low computational cost. This is achieved by (1) using Lindley’s recursion to allow for explicit expressions and (2) choosing a discrete-time (slotted) setting to make those expressions easy to compute. We assume general, possibly distinct, distributions for the patients’ consultation times, which allows to account for multiple treatment types, emergencies and patient no-shows. The moments of waiting and idle times are obtained and the computational complexity of the algorithm is discussed. Additionally, we calculate the schedule’s performance in between appointments in order to assist a sequential scheduling strategy.     

Conservative independence-based causal structure learning in absence of adjacency faithfulness

This paper presents an extension to the Conservative PC algorithm which is able to detect violations of adjacency faithfulness under causal sufficiency and triangle faithfulness. Violations can be characterized by pseudo-independent relations and equivalent edges, both generating a pattern of conditional independencies that cannot be modeled faithfully. Both cases lead to uncertainty about specific parts of the skeleton of the causal graph. These ambiguities are modeled by an f-pattern. We prove that our Adjacency Conservative PC algorithm is able to correctly learn the f-pattern. We argue that the solution also applies for the finite sample case if we accept that only strong edges can be identified. Experiments based on simulations and the ALARM benchmark model show that the rate of false edge removals is significantly reduced, at the expense of uncertainty on the skeleton and a higher sensitivity for accidental correlations.     

Direct electroplating of copper on tantalum from ionic liquids in high vacuum: origin of the tantalum oxide layer

In this paper, it is shown that high vacuum conditions are not sufficient to completely remove water and oxygen from the ionic liquid 1-ethyl-3-methylimidazolium chloride. Complete removal of water demands heating above 150 °C under reduced pressure, as proven by Nuclear Reaction Analysis (NRA). Dissolved oxygen gas can only be removed by the use of an oxygen scavenger such as hydroquinone, despite the fact that calculations show that oxygen should be removed completely by the applied vacuum conditions. After applying a strict drying procedure and scavenging of molecular oxygen, it was possible to deposit copper directly on tantalum without the presence of an intervening oxide layer.     

Oscillating electrochemical reaction in copper-containing imidazolium ionic liquids

An example of an electrochemical oscillator in ionic liquids is presented. Solutions of the ionic liquid 1-ethyl-3-methylimidazolium chloride, [C(2)mim]Cl, which contain both Cu(+) and Cu(2+) ions, show current oscillations during potentiostatic polarization. The oscillations were analyzed by the Quartz Crystal Microbalance (QCM) technique and by Electrochemical Impedance Spectroscopy (EIS). The electrochemical oscillations are of the N-NDR-type, because the low frequency end of the impedance spectrum has negative real impedances. The oscillating current leads to an oscillating growth speed of a metallic copper layer. Besides the presence of both Cu(+) and Cu(2+), the presence of chloride is a necessary, yet not a sufficient, condition for the occurrence of current oscillations. Oscillating currents were also observed for the ionic liquids 1-butyl-3-methylimidazolium chloride and 1-butyl-2,3-dimethylimidazolium chloride, but not for tributyltetradecylphosphonium chloride and N-butylpyridinium chloride.     

Silver halide colloid precursors for the synthesis of monolayer-protected clusters

A new method for the synthesis of monolayer-protected silver clusters (MPCs) based on the two-phase reduction of a stable negatively charged silver bromide sol is described. Phase transfer of the colloid to toluene is accomplished using tetra-n-octylammonium bromide as the phase transfer reagent. The advantage of this synthesis is to uncouple the formation of the silver halide colloid from its transfer and reduction in the organic phase, thus allowing control over each reaction step. The silver colloid in toluene was reduced with aqueous borohydride in the presence of 4-bromobenzenethiol as the passivating agent. The UV-visible absorption spectra indicate the intermediate formation of Ag(core)AgBr(shell) clusters during reduction. The resulting MPCs have been characterized by optical and transmission electron microscopy, energy-dispersive X-ray analysis, thermogravimetry, and UV-vis absorption spectroscopy. The formation of spiral cracks in the nanoparticulate agglomerates on solvent evaporation was observed. The spectra of thin films obtained by solvent evaporation have been analyzed using an effective medium theory.     

Every Banach Space is Reflexive

The title above is wrong, because the strong dual of a Banach space is too strong to assert that the natural correspondence between a space and its bidual is an isomorphism. However, for many applications it suffices to replace the norm on the first dual by the weak*-structure in order to solve the non-reflexiveness problem [1]. But in this way, only the original vector space is recovered by taking the second dual. In this work we introduce a suitable numerical structure on vector spaces such that Banach balls, or more precisely totally convex modules, arise naturally in duality, namely as a category of Eilenberg–Moore algebras. This numerical structure naturally overlies the weak*-topology on the algebraic dual, so the entire Banach space can be reconstructed as a second dual. Moreover, the isomorphism between the original space and its bidual is the unit of an adjunction between the two-dualisation functors. Notice that the weak*-topology is normable only if it lives on a finite dimensional space; in that case the original space is trivial as well, hence reflexive. So the overlying numerical structure should be something more general than a norm or a seminorm and thus approach theory [2, 3] enters the picture.     

Radical C?H Arylation of the BODIPY Core with Aryldiazonium Salts: Synthesis of Highly Fluorescent Red‐Shifted Dyes

We describe herein the first radical C H arylation of BODIPY dyes. This novel, general, one‐step synthetic procedure uses ferrocene to generate aryl radical species from aryldiazonium salts and allows the straightforward synthesis of brightly fluorescent (Φ>0.85) 3,5‐diarylated and 3‐monoarylated boron dipyrrins in up to 86 % yield for a broad range of aryl substituents. In this way, new and complex dyes with red‐shifted spectra can be easily prepared.     

Strategies for detecting fraudulent claims in the automobile insurance industry

Some property and casualty insurers use automated detection systems to help to decide whether or not to investigate claims suspected of fraud. Claim screening systems benefit from the coded experience of previously investigated claims. The embedded detection models typically consist of scoring devices relating fraud indicators to some measure of suspicion of fraud. In practice these scoring models often focus on minimizing the error rate rather than on the cost of (mis)classification. We show that focusing on cost is a profitable approach. We analyse the effects of taking into account information on damages and audit costs early on in the screening process. We discuss several scenarios using real-life data. The findings suggest that with claim amount information available at screening time detection rules can be accommodated to increase expected profits. Our results show the value of cost-sensitive claim fraud screening and provide guidance on how to render this strategy operational.     

Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid

The hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid shows excellent yields (>90%) for hexitols.     

Extracting organic contaminants from water using the metal-organic framework CrIII(OH)·{O2C-C6H4-CO2}

The water-stable metal-organic framework MIL-53(Cr) is able to adsorb phenol and p-cresol from contaminated water as well as the monomeric sugar D-(-)-fructose. Based on the isotherm for phenol uptake from the liquid phase, it is proposed that the framework breathes to maximize the uptake.