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61.
González-Núñez ME Mello R Royo J Asensio G Monzó I Tomás F López JG Ortiz FL 《The Journal of organic chemistry》2005,70(9):3450-3457
[reaction: see text] Data on the apparent dipole moment of thianthrene-5-oxide (1) and (1)H NMR spectra in different solvents support the conformational mobility of 1, which flaps between two limit boat conformations with the sulfinyl group in pseudoequatorial and pseudoaxial positions, respectively. The conformational equilibrium of 1 occurs too fast for the (1)H NMR (500 MHz) time-scale even at -130 degrees C, and the equilibrium constant has not been determined. The apparent dipole moments of 1 in n-hexane and 1,4-dioxane and the (1)H NMR spectra of 1 and the model compounds cis- and trans-thianthrene-5,10-dioxides (2) and thianthrene (5) in different solvents and at various temperatures confirm that the relative position of the conformational equilibrium of 1 is solvent-dependent, and more polar solvents favor the conformation with the sulfoxide group in the pseudoaxial position (1(')(ax)). Variable-temperature (1)H NMR spectra have established the interconversion barrier of trans-2 and confirmed that the conformational equilibrium of cis-2 is strongly displaced toward the conformation with both sulfinyl groups in the pseudoequatorial position. The (1)H NMR data support the transannular interaction of the functional groups in 1 and trans-2. 相似文献
62.
Martínez-Lozano JA Marín MJ Tena F Utrillas MP Sánchez-Muniosguren L González-Frías C Cuevas E Redondas A Lorente J de Cabo X Cachorro V Vergaz R de Frutos A Díaz JP Expósito FJ de la Morena B Vilaplana JM 《Photochemistry and photobiology》2002,76(2):181-187
An analysis is made of experimental ultraviolet erythemal solar radiation data measured during the years 2000 and 2001 by the Spanish UV-B radiation evaluation and prediction network. This network consists of 16 Robertson-Berger type pyranometers for evaluating solar erythemal radiation and five Brewer spectroradiometers for evaluating the stratospheric ozone. On the basis of these data the Ultraviolet Index (UVI) was evaluated for the measuring stations that are located either in coastal regions or in the more densely populated regions inland on the Iberian Peninsula. It has been checked that in most cases the maximum irradiance values corresponded to solar noon, although there were exceptions that could be explained by cloudiness. The maximum experimental values of the UVI were around 9 during the summer, though frequently passing this value at the inland measurement stations. The annual accumulated dose of irradiation on a horizontal plane has also been studied, as well as the evolution through the year in units of energy, standard erythemal doses and minimum erythemal doses, according to different phototypes. 相似文献
63.
To test the applicability of the WKB semiclassical approximation to correctly describe the tunneling frequencies and energy levels in asymmetric double wells, we have considered the cases where the asymmetry comes from the nondegeneracy of the two minima and when it comes from the asymmetry in the shape of the barrier between both minima. To do this, we compare the tunneling frequencies and energy levels obtained through the WKB method for symmetric and asymmetric cases with exact results obtained by a basis set procedure. Our results show that the semiclassical WKB approximation has to be used with caution for asymmetric double wells. © 1994 by John Wiley & Sons, Inc. 相似文献
64.
A chemometric study on the prediction of the main nutritional aspects of milk has been carried out by using fourier transform infrared spectroscopy (FTIR) attenuated total reflectance (ATR) measurements of commercially available milk samples of different types. Whole, semi and skimmed milks, enriched or not with calcium, vitamins or modified by alteration of lipid or sugar composition were considered. After evaluating different strategies for data acquisition and ATR cleaning between samples, hierarchical cluster analysis (HCA) was carried out for classification of samples in order to choose the calibration set. The prediction capabilities of partial least squares (PLS) data treatment were evaluated in order to obtain information about total fat, total protein, total carbohydrates (CH), calories and calcium. On using the mean square error of cross-validation and prediction as control variables, a critical evaluation were made about the calibration set to be used, the spectral range to be considered and the data treatment (PLS-1 or PLS-2) to be performed. By selecting a calibration set of 33 samples the properties of 48 samples were predicted with relative precision of triplicates of 0.062, 0.040 and 0.039% w/v for total fat, protein and carbohydrates, and 0.66 kcal/100 ml for calories, and 2.1 mg of Ca/100 ml. The mean difference (dx−y) between predicted and actual values and standard deviation of mean differences (sx−y), were of 0.06 (0.38), 0.03 (0.18) and −0.15 (0.41), being sx−y values between brackets, for total fat, proteins and carbohydrates, 0.06 (3.8) kcal/100 ml for calories and −4.5 (9) mg/100 ml for calcium.The sensitivity and selectivity of the methodology developed were evaluated on terms of the net analyte signal. Selectivity factors ranging from 2 to 7.6% have been calculated for the five parameters considered. 相似文献
65.
Microwave irradiation has been successfully applied in organic chemistry. Spectacular accelerations, higher yields under milder reaction conditions and higher product purities have all been reported. Indeed, a number of authors have described success in reactions that do not occur by conventional heating and even modifications of selectivity (chemo-, regio- and stereoselectivity). The effect of microwave irradiation in organic synthesis is a combination of thermal effects, arising from the heating rate, superheating or "hot spots" and the selective absorption of radiation by polar substances. Such phenomena are not usually accessible by classical heating and the existence of non-thermal effects of highly polarizing radiation--the "specific microwave effect"--is still a controversial topic. An overview of the thermal effects and the current state of non-thermal microwave effects is presented in this critical review along with a view on how these phenomena can be effectively used in organic synthesis. 相似文献
66.
Fernando A Iñón 《Analytica chimica acta》2003,477(1):59-71
A mathematical model for fitting the experimental ICM (integrated conductimetric method) curves developed by the authors in a previous work, is presented for the first time in this study. The proposed model fits the experimental curves with great precision and allows to predict physical dispersion for single-line flow injection system. The correlation of the model’s parameters with typical reactionless FIA peak parameters is also assessed. The IDQ coefficient—a novel dispersion estimator previously reported by the authors—can also be predicted when operational FIA variables are changed. Experimental and modelled profiles are compared as a function of the system’s variables, showing an excellent agreement. 相似文献
67.
Fernando C. Macedo Jr. 《Tetrahedron letters》2004,45(1):53-55
A novel metabolite from Aspergillus terreus, named terreinol, was isolated and its biosynthetic origin was determined by NMR based on the incorporation of [1-13C]-d-glucose. The labeling pattern indicated a predominant polyketide biosynthetic origin for this metabolite. 相似文献
68.
Aschi M Lucente G Mazza F Mollica A Morera E Nalli M Paglialunga Paradisi M 《Organic & biomolecular chemistry》2003,1(11):1980-1988
The conformational study of a new group of synthetic peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt), a cysteine-related achiral residue, has been carried out through a joint application of computational and experimental methodologies. Molecular Dynamics simulations clearly suggest the tendency of this molecule to adopt a gamma-turn conformation in vacuum and help in analyzing the complex and crucial conformational behaviour of the dithiolane ring which appears to preferentially adopt a C(S)-like structure. Electronic structure calculations carried out in solution using the Density Functional Theory also indicate the preservation of the gamma-like folding in apolar solvents and the helix-like one in more polar solvents. A comparison with the achiral 1-aminocycloalkane-1-carboxylic acid (Ac5c) has been carried out using the same computational tools. NMR and IR data on dipeptide derivatives containing the Adt or Ac5c residue show that in chloroform solution all the models prefer a gamma-turn structure, centered at the cyclic residue, stabilized by an intramolecular H-bond, whereas in a more polar solvent, i.e. dimethyl sulfoxide, this folding is not maintained. The experimental conformational studies, extended to N-Boc protected tripeptides, clearly indicate the remarkable tendency of both the five-membered C(alpha)-tetrasubstituted cyclic amino acids Adt and Ac5c to induce the gamma-turn structure also in models able to adopt the beta-bend conformation. 相似文献
69.
M. Moreno M. T. Barriuso J. A. Aramburu 《International journal of quantum chemistry》1994,52(4):829-835
Experimental results on 3d Oh complexes in insulators reveal that 10Dq α R?n, where R is the metal–ligand distance and n is close to five. This strong dependence determines the Huang–Rhys factor, S(A1g), associated to the symmetric A1g mode of the first excited state of complexes like MnX and CrX (X = halide) and makes it possible to measure R changes down to ∽ 10?3 Å. This work is devoted to understanding, within a molecular orbital framework, the microscopic origin of such a dependence, which is related to the corresponding one displayed by the transferred spin densities fσ, fs, and fπ. The analysis is focused on MnF. As a main result, it is shown that though fσ ? fs the interaction between d(eg) orbitals and 2s orbitals of F? is not only primarily responsible for the R dependence of 10Dq but also makes a significant contribution to the 10Dq value itself. The present work thus shows that the significant dependence of 10Dq upon R is ultimately related to the strong dependence of fs and the isotropic superhyperfine constant As upon R displayed by the experimental results of several 3d impurities. © John Wiley & Sons, Inc. 相似文献
70.
Menezes PH Gonçalves SM Hallwass F Silva RO Bieber LW Simas AM 《Organic letters》2003,5(10):1601-1604
[reaction: see text] Several (77)Se NMR experiments were performed by titrating a sample of selenides with the chiral shift reagent methylbenzylamine (MBA), followed by acquisition of (77)Se NMR spectra. Eventually, we observed the appearance of two anisochronous resonances, with a relatively large separation, from 37 to 56 Hz, corresponding to the formation of the diastereomeric complexes. This methodology avoids derivatization processes, and the studied compound can be easily recovered from the NMR tube. 相似文献