SCOTfluors: Small,Conjugatable, Orthogonal,and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.     

Photoelectrochemical oxidation of glycerol on hematite: thermal effects,in situ FTIR and long-term HPLC product analysis

Journal of Solid State Electrochemistry - Photoelectrochemical (PEC) oxidation of biomass is a profitable approach to produce hydrogen by substituting the water oxidation reaction in the...     

Summary of ISO/TC 201 International Standard ISO 18516:2019 Surface chemical analysis—Determination of lateral resolution and sharpness in beam-based methods with a range from nanometres to micrometres and its implementation for imaging laboratory X-ray photoelectron spectrometers (XPS)

ISO 18516:2019 Surface chemical analysis—Determination of lateral resolution and sharpness in beam-based methods with a range from nanometres to micrometres revises ISO 18516:2006 Surface chemical analysis—Auger electron spectroscopy and X-ray photoelectron spectroscopy—Determination of lateral resolution. It implements three different methods delivering parameters useful to express the lateral resolution: (1) the straight edge method, (2) the narrow line method and (3) the grating method. The theoretical background of these methods is introduced in ISO/TR 19319:2013 Surface chemical analysis—Fundamental approaches to determination of lateral resolution and sharpness in beam-based methods. The revised International Standard ISO 18516 delivers standardized procedures for the determination of the (1) effective lateral resolution by imaging of square-wave gratings, the (2) lateral resolution expressed as the parameter D_12–88 characterizing the steepness of the sigmoidal edge spread function (ESF) determined by imaging a straight edge and (3) the lateral resolution expressed as the full width of half maximum of the line spread function (LSF), w_LSF, determined by imaging a narrow line. The last method also delivers information on the shape of the LSF, which characterizes an individual imaging instrument. Finally, the implementation of all three standardized methods in the field of imaging laboratory X-ray photoelectron spectroscopy (XPS) is shortly presented. This part of the letter is based on the use of a new test sample developed at ETH Zurich, Switzerland. This test sample displays a micrometre scaled pattern motivated by the resolving power of recent imaging XPS instruments.     

Search for heavy neutral leptons in e+e− annihilations at 29 GeV

A search was made in 29 GeV e⁺e^? annihilations for heavy, neutral leptons decaying to e^±X^?(ν), where X is a muon or charged meson. Six events with isolated e^±X^? pairs were found for an intergrated luminosity of 106 pb^?1. The expected background is 5.5 ± 2.2 events. Limits on $\text{σ}\text{s}\text{?}\text{B}$ depend on mass and range from 8 to 20 × 10^?5 nb.     

Synthesis of 2-substituted 4-quinazolone-5-carboxylic acids as inhibitors of DNA-gyrase

A series of 4-quinazolone-5-carboxylic acids were designed as bacterial DNA gyrase inhibitors. The syntheses of the target compounds were accomplished by reacting 3-aminophthalimide with aroyl chlorides followed by rearrangement of the resulting 3-acylaminophthalimides under basic conditions. The designed compounds showed moderate DNA gyrase inhibitory activity.     

A study of Bose-Einstein correlations ine+e? annihilation at 91 GeV

This paper describes a study of Bose-Einstein correlations made using the ALEPH detector at LEP. The correlations are found to enhance the two particle differential cross section for pairs of identical pions by a factor which can be roughly parametrized byR(Q)=1+ exp(-Q²²), whereQ is the difference in the 3-momenta of the two pions in their centre of mass frame, =0.51±0.04±0.11 and =3.3±0.2±0.8 GeV^–1, which corresponds to a source size of 0.65±0.04±0.16 fm. The large systematic errors on these results reflect their strong dependence on the choice of the reference sample used in the analysis. This problem is believed to occur primarily because of uncertainties in the rates of resonance production and a lack of knowledge about the pion-pion strong interaction. No significant correlations are seen amongst like-charged pion-kaon pairs.Supported by CAICYT, Spain     

Hybrid Organic–Inorganic Rotaxanes,Including a Hetero‐Hybrid [3]Rotaxane Featuring Two Distinct Heterometallic Rings and a Molecular Shuttle

[2] and [3] hybrid rotaxanes are reported based on {Ti₇M} rings (M is a trivalent metal such as Fe^III or Ga^III). NMR studies show that [2]rotaxanes can act as molecular shuttles, while EPR studies of [3]rotaxanes show weak interactions between the paramagnetic components of the supramolecular assemblies.     

The Reaction of SnCl2 with Br2 and I2 in Weak Donor Solvents

The compounds SnCl₂Br₂(MeCN)₂, “Sn₃Cl₈Br₄(THF)₆”, and “Sn₃Cl₁₀Br₂(OEt₂)₆” were obtained by reaction between SnCl₂ and Br₂ in acetonitrile (MeCN), tetrahydrofuran (THF) and diethyl ether (OEt₂). The two last are solid solutions of SnCl₄L₂ and SnCl₂Br₂L₂ (L = THF, OEt₂) in the proportions 1:2 and 2:1, respectively. The compounds are characterized by IR, Raman, and Mössbauer spectroscopy, a C₁ symmetry being found for SnCl₂Br₂ (MeCN)₂ together with a C_2v symmetry, with the ligands in trans positions, for SnCl₂Br₂L₂ (L = THF, OEt₂). The Mössbauer spectrum of SnBr₄(THF)₂ was also obtained, which has not previously been reported. The reaction between SnCl₂ and I₂ has also been studied in the same solvents, and the formation of SnCl₄L₂ (L = MeCN, THF, OEt₂), SnI₄, and a small amount of SnI₃Cl was observed, which have been identified by Raman spectroscopy.