全文获取类型
收费全文 | 9026篇 |
免费 | 1504篇 |
国内免费 | 1140篇 |
专业分类
化学 | 6535篇 |
晶体学 | 210篇 |
力学 | 501篇 |
综合类 | 99篇 |
数学 | 927篇 |
物理学 | 3398篇 |
出版年
2024年 | 30篇 |
2023年 | 212篇 |
2022年 | 461篇 |
2021年 | 428篇 |
2020年 | 482篇 |
2019年 | 517篇 |
2018年 | 451篇 |
2017年 | 435篇 |
2016年 | 563篇 |
2015年 | 596篇 |
2014年 | 653篇 |
2013年 | 848篇 |
2012年 | 953篇 |
2011年 | 882篇 |
2010年 | 657篇 |
2009年 | 609篇 |
2008年 | 602篇 |
2007年 | 484篇 |
2006年 | 365篇 |
2005年 | 307篇 |
2004年 | 234篇 |
2003年 | 166篇 |
2002年 | 153篇 |
2001年 | 110篇 |
2000年 | 77篇 |
1999年 | 79篇 |
1998年 | 40篇 |
1997年 | 47篇 |
1996年 | 50篇 |
1995年 | 49篇 |
1994年 | 20篇 |
1993年 | 25篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 17篇 |
1989年 | 9篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 4篇 |
1936年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
研究了一类具有Neumann边界条件的抛物方程解的性质,通过微分方法得到了一类边值问题解的估计,并得到了拟线性方程解的存在性. 相似文献
102.
利用浓盐酸脱苯基方法合成混合二烃基二氯化锡 总被引:1,自引:1,他引:0
利用RSnPh3(R= Me3SiCH2、EtMe2SiCH2、Bu)和浓盐酸直接混合加热反应,合成了三种混合二烃基二氯化锡,通过IR,1H NMR和MS的测定,对产物的结构进行了表征;并探讨了反应时间、温度和浓盐酸用量对该反应产率的影响.实验结果表明,该方法与其它方法比较,具有操作简单、反应速度快、环境污染小、产率较高等特点;当四烃基锡与浓盐酸的物质的量比为1:8,在97 ℃反应7 min,混合二烃基二氯化锡的产率大于70%. 相似文献
103.
Tingjunhong Ni Zichao Ding Fei Xie Yumeng Hao Junhe Bao Jingxiang Zhang Shichong Yu Yuanying Jiang Dazhi Zhang 《Molecules (Basel, Switzerland)》2022,27(11)
A series of triazole derivatives containing phenylethynyl pyrazole moiety as side chain were designed, synthesized, and most of them exhibited good in vitro antifungal activities. Especially, compounds 5k and 6c showed excellent in vitro activities against C. albicans (MIC = 0.125, 0.0625 μg/mL), C. neoformans (MIC = 0.125, 0.0625 μg/mL), and A. fumigatus (MIC = 8.0, 4.0 μg/mL). Compound 6c also exerted superior activity to compound 5k and fluconazole in inhibiting hyphae growth of C. albicans and inhibiting drug-resistant strains of C. albicans, and it could reduce fungal burdens in mice kidney at a dosage of 1.0 mg/kg. An in vivo efficacy evaluation indicated that 6c could effectively protect mice models from C. albicans infection at doses of 0.5, 1.0, and 2.0 mg/kg. These results suggested that compound 6c deserves further investigation. 相似文献
104.
105.
Xiuxiu Wang Zong-Chang Han Wei Wei Hanshi Hu Pengfei Li Peiqing Sun Xiangzhi Liu Zhijia Lv Feng Wang Yi Cao Zijian Guo Jun Li Jing Zhao 《Chemical science》2022,13(24):7269
Metal clusters, such as iron–sulfur clusters, play key roles in sustaining life and are intimately involved in the functions of metalloproteins. Herein we report the formation and crystal structure of a planar square tetranuclear silver cluster when silver ions were mixed with human copper chaperone Atox1. Quantum chemical studies reveal that two Ag 5s1 electrons in the tetranuclear silver cluster fully occupy the one bonding molecular orbital, with the assumption that this Ag4 cluster is Ag42+, leading to extensive electron delocalization over the planar square and significant stabilization. This bonding pattern of the tetranuclear silver cluster represents an aromatic all-metal structure that follows a 4n + 2 electron counting rule (n = 0). This is the first time an all-metal aromatic silver cluster was observed in a protein.Metal clusters, such as iron–sulfur clusters, play key roles in sustaining life and are intimately involved in the functions of metalloproteins. 相似文献
106.
Drug–drug interactions (DDIs) can trigger unexpected pharmacological effects on the body, and the causal mechanisms are often unknown. Graph neural networks (GNNs) have been developed to better understand DDIs. However, identifying key substructures that contribute most to the DDI prediction is a challenge for GNNs. In this study, we presented a substructure-aware graph neural network, a message passing neural network equipped with a novel substructure attention mechanism and a substructure–substructure interaction module (SSIM) for DDI prediction (SA-DDI). Specifically, the substructure attention was designed to capture size- and shape-adaptive substructures based on the chemical intuition that the sizes and shapes are often irregular for functional groups in molecules. DDIs are fundamentally caused by chemical substructure interactions. Thus, the SSIM was used to model the substructure–substructure interactions by highlighting important substructures while de-emphasizing the minor ones for DDI prediction. We evaluated our approach in two real-world datasets and compared the proposed method with the state-of-the-art DDI prediction models. The SA-DDI surpassed other approaches on the two datasets. Moreover, the visual interpretation results showed that the SA-DDI was sensitive to the structure information of drugs and was able to detect the key substructures for DDIs. These advantages demonstrated that the proposed method improved the generalization and interpretation capability of DDI prediction modeling.SA-DDI is designed to learn size-adaptive molecular substructures for drug–drug interaction prediction and can provide explanations that are consistent with pharmacologists. 相似文献
107.
108.
A series of novel N-dichloroacetyl oxazolidine herbicide safeners was synthesized and characterized by IR, 1H NMR, 13C NMR, elemental analysis and X-ray diffraction. The preliminary biological test shows that the compounds could protect maize against injury caused by chlorsulfuron to a certain extent. 相似文献
109.
Bingxue Lv Jiahao Ren Yang Chen Siyu Guo Minqian Wu Lijun You 《Molecules (Basel, Switzerland)》2022,27(15)
In this study, a polysaccharide-based hydrogel microsphere (SFP/SA) was prepared using S. fusiforme polysaccharide (SFP) and sodium alginate (SA). Fourier transform infrared spectroscopy (FT-IR) demonstrated that SFP was effectively loaded onto the hydrogel microsphere. Texture profile analysis (TPA) and differential scanning calorimetry (DSC) showed that, with the increase of SFP concentration, the hardness of SFP/SA decreased, while the springiness and cohesiveness of SFP/SA increased, and the thermal stability of SFP/SA improved. The equilibrium adsorption capacity of SFP/SA increased from 8.20 mg/g (without SFP) to 67.95 mg/g (SFP accounted 80%) without swelling, and from 35.05 mg/g (without SFP) to 81.98 mg/g (SFP accounted 80%) after 24 h swelling. The adsorption of crystal violet (CV) dye by SFP/SA followed pseudo-first order and pseudo-second order kinetics (both with R2 > 0.99). The diffusion of intraparticle in CV dye was not the only influencing factor. Moreover, the adsorption of CV dye for SFP/SA (SFP accounted 60%) fit the Langmuir and Temkin isotherm models. SFP/SA exhibited good regenerative adsorption capacity. Its adsorption rate remained at > 97% at the 10th consecutive cycle while SFP accounted for 80%. The results showed that the addition of Sargassum fusiforme polysaccharide could increase the springiness, cohesiveness and thermal stability of the hydrogel microsphere, as well as improve the adsorption capacity of crystal violet dye. 相似文献
110.
Information-rich molecules provide opportunities for evolution. Genetically engineered materials are superior in that their properties are coded within genetic sequences and could be fine-tuned. In this review, we elaborate the concept of genetically engineered materials(GEMs) using examples ranging from engineered protein materials to engineered living materials. Proteinbased materials are the materials of choice by nature. Recent progress in protein engineering has led to opportunities to tune... 相似文献