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51.
Arslan Iftikhar Rimsha Nausheen Humaira Muzaffar Muhammad Ahsan Naeem Muhammad Farooq Mohsin Khurshid Ahmad Almatroudi Faris Alrumaihi Khaled S. Allemailem Haseeb Anwar 《Molecules (Basel, Switzerland)》2022,27(10)
Honey is the principal premier product of beekeeping familiar to Homo for centuries. In every geological era and culture, evidence can be traced to the potential usefulness of honey in several ailments. With the advent of recent scientific approaches, honey has been proclaimed as a potent complementary and alternative medicine for the management and treatment of several maladies including various neurological disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, etc. In the literature archive, oxidative stress and the deprivation of antioxidants are believed to be the paramount cause of many of these neuropathies. Since different types of honey are abundant with certain antioxidants, primarily in the form of diverse polyphenols, honey is undoubtedly a strong pharmaceutic candidate against multiple neurological diseases. In this review, we have indexed and comprehended the involved mechanisms of various constituent polyphenols including different phenolic acids, flavonoids, and other phytochemicals that manifest multiple antioxidant effects in various neurological disorders. All these mechanistic interpretations of the nutritious components of honey explain and justify the potential recommendation of sweet nectar in ameliorating the burden of neurological disorders that have significantly increased across the world in the last few decades. 相似文献
52.
Nima Nayema Islam Ferdows M. Adesanya S. O. Alzahrani Faris 《Journal of Thermal Analysis and Calorimetry》2021,145(5):2571-2580
Journal of Thermal Analysis and Calorimetry - The present paper concerns the bioconvective flow, mass and heat transfer including motile microorganisms on a vertical surface saturated with porous... 相似文献
53.
Ibrahim A. Abbas Faris S. Alzahrani Ahmed Elaiw 《Waves in Random and Complex Media》2019,29(2):328-343
The generalized model for plasma, thermal, and elastic waves under dual phase lag model have been applied to determine the carrier density, the displacement, the temperature, and the stresses in a semiconductor medium. Using Laplace transform and the eigenvalue approach methodology, the solutions of all variables have been obtained analytically. A semiconducting material like as silicon was considered. The results were graphically represented to show the different between the dual phase model, Lord and Shulman’s theory and the classical dynamical coupled theory. 相似文献
54.
William G Faris 《Journal of Functional Analysis》1979,32(3):342-352
The stochastic Heisenberg model is a classical mechanical model for a magnet in contact with a medium at fixed temperature. The dynamics in the infinite volume limit is a well-defined Markov process. Equilibrium states exist, and in this limit there is the possibility of multiple equilibrium states at low temperature, corresponding to different directions of magnetism. 相似文献
55.
Frequency-domain immersion technique for accurate optical property measurements of turbid media 总被引:1,自引:0,他引:1
We demonstrate that absorption coefficient micro(a) and reduced scattering coefficient micro(s)(?) of a small turbid object can be measured to high accuracy with a frequency-domain immersion technique. For this technique the sample is immersed in a calibrated scattering medium and the optical properties are obtained from a differential measurement. Compared with conventional approaches, the immersion technique improves accuracy, minimizes variations owing to probe coupling and motion, reduces the effects of boundary conditions, and offers simple and rapid measurement once the immersion medium is calibrated. Accuracy tests of immersion-based measurements of micro(a) and micro(s)(?) agree with reference values to within 3.6% and 2.6%, respectively. These tests are limited by the accuracy of the reference samples rather than by the accuracy of the immersion medium or the precision of the immersion approach. We demonstrate the in vivo capabilities of the technique through time-resolved measurements of micro(a) and micro(s)(?) for a human hand during cuff occlusion on the upper arm. 相似文献
56.
H. Bergström G. W. Faris H. Hallstadius H. Lundberg A. Persson C. -G. Wahlström 《Zeitschrift für Physik D Atoms, Molecules and Clusters》1988,8(1):17-23
The neutral boron atom has been investigated using laser spectroscopic techniques for the first time. Radiative lifetimes have been measured for the 3p 2 P and 4p 2 P states and the hyperfine-structure splitting of the 4p 2 P 3/2 level has been determined. Laser evaporation was used for production of free atoms. The experimental results are compared with theoretical ab initio calculations. 相似文献
57.
Mahmoud A. A. Ibrahim Alaa H. M. Abdelrahman Tarik A. Mohamed Mohamed A. M. Atia Montaser A. M. Al-Hammady Khlood A. A. Abdeljawaad Eman M. Elkady Mahmoud F. Moustafa Faris Alrumaihi Khaled S. Allemailem Hesham R. El-Seedi Paul W. Par Thomas Efferth Mohamed-Elamir F. Hegazy 《Molecules (Basel, Switzerland)》2021,26(7)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (Mpro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area binding energy calculations. On the basis of in silico analyses, six terpenes demonstrated high potency as Mpro inhibitors with ΔGbinding ≤ −40.0 kcal/mol. The stability and binding affinity of the most potent metabolite, erylosides B, were compared to the human immunodeficiency virus protease inhibitor, lopinavir. Erylosides B showed greater binding affinity towards SARS-CoV-2 Mpro than lopinavir over 100 ns with ΔGbinding values of −51.9 vs. −33.6 kcal/mol, respectively. Protein–protein interactions indicate that erylosides B biochemical signaling shares gene components that mediate severe acute respiratory syndrome diseases, including the cytokine- and immune-signaling components BCL2L1, IL2, and PRKC. Pathway enrichment analysis and Boolean network modeling were performed towards a deep dissection and mining of the erylosides B target–function interactions. The current study identifies erylosides B as a promising anti-COVID-19 drug lead that warrants further in vitro and in vivo testing. 相似文献
58.
AL-Oqla Faris M. Hayajneh Mohammed T. Al-Shrida Muayyad M. 《Cellulose (London, England)》2022,29(6):3293-3309
Cellulose - Sustainable bio-materials are now potential alternatives for synthetic composites to achieve more functional green products. However, the microstructure-performance synergy is critical... 相似文献
59.
Wahid Ali Hamood Altowayti Norzila Othman Adel Al-Gheethi Nur Hasniza binti Mohd Dzahir Syazwani Mohd Asharuddin Abdullah Faisal Alshalif Ibrahim Mohammed Nasser Husnul Azan Tajarudin Faris Ali Hamood AL-Towayti 《Molecules (Basel, Switzerland)》2021,26(20)
Sustainable wastewater treatment is one of the biggest issues of the 21st century. Metals such as Zn2+ have been released into the environment due to rapid industrial development. In this study, dried watermelon rind (D-WMR) is used as a low-cost adsorption material to assess natural adsorbents’ ability to remove Zn2+ from synthetic wastewater. D-WMR was characterized using scanning electron microscope (SEM) and X-ray fluorescence (XRF). According to the results of the analysis, the D-WMR has two colours, white and black, and a significant concentration of mesoporous silica (83.70%). Moreover, after three hours of contact time in a synthetic solution with 400 mg/L Zn2+ concentration at pH 8 and 30 to 40 °C, the highest adsorption capacity of Zn2+ onto 1.5 g D-WMR adsorbent dose with 150 μm particle size was 25 mg/g. The experimental equilibrium data of Zn2+ onto D-WMR was utilized to compare nonlinear and linear isotherm and kinetics models for parameter determination. The best models for fitting equilibrium data were nonlinear Langmuir and pseudo-second models with lower error functions. Consequently, the potential use of D-WMR as a natural adsorbent for Zn2+ removal was highlighted, and error analysis indicated that nonlinear models best explain the adsorption data. 相似文献
60.
Faris Alrumaihi 《Molecules (Basel, Switzerland)》2021,26(21)
Homeostatic trafficking of immune cells by CC chemokine receptor 7 (CCR7) keeps immune responses and tolerance in a balance. The involvement of this protein in lymph node metastasis in cancer marks CCR7 as a penitential drug target. Using the crystal structure of CCR7, herein, a comprehensive virtual screening study is presented to filter novel strong CCR7 binding phytochemicals from Saudi medicinal plants that have a higher binding affinity for the intracellular allosteric binding pocket. By doing so, three small natural molecules named as Hit-1 (1,8,10-trihydroxy-3-methoxy-6-methylanthracen-9(4H)-one), Hit-2 (4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one), and Hit-3 (10-methyl-12,13-dihydro-[1,2]dioxolo[3,4,5-de]furo[3,2-g]isochromeno[4,3-b]chromen-8-ol) are predicted showing strong binding potential for the CC chemokine receptor 7 allosteric pocket. During molecular dynamics simulations, the compounds were observed in the formation of several chemical bonding of short bond distances. Additionally, the molecules remained in strong contact with the active pocket residues and experienced small conformation changes that seemed to be mediated by the CCR7 loops to properly engage the ligands. Two types of binding energy methods (MM/GBPBSA and WaterSwap) were additionally applied to further validate docking and simulation findings. Both analyses complement the good affinity of compounds for CCR7, the electrostatic and van der Waals energies being the most dominant in intermolecular interactions. The active pocket residue’s role in compounds binding was further evaluated via alanine scanning, which highlighted their importance in natural compounds binding. Additionally, the compounds fulfilled all drug-like rules: Lipinski, Ghose, Veber, Egan, and Muegge passed many safety parameters, making them excellent anti-cancer candidates for experimental testing. 相似文献