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Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the synovial joints. A highly potent antagonist of C-C chemokine receptor 5 (CCR5), maraviroc (MVC), plays an essential role in treating several infectious diseases but has not yet been evaluated for its potential effects on RA development. This study focused on evaluating the therapeutic potential of MVC on collagen-induced arthritis (CIA) in DBA/1J mice. Following CIA induction, animals were treated intraperitoneally with MVC (50 mg/kg) daily from day 21 until day 35 and evaluated for clinical score and histopathological changes in arthritic inflammation. We further investigated the effect of MVC on Th9 (IL-9, IRF-4, and GATA3) and Th17 (IL-21R, IL-17A, and RORγT) cells, TNF-α, and RANTES in CD8+ T cells in the spleen using flow cytometry. We also assessed the effect of MVC on mRNA and protein levels of IL-9, IL-17A, RORγT, and GATA3 in knee tissues using RT-PCR and western blot analysis. MVC treatment in CIA mice attenuated the clinical and histological severity of inflammatory arthritis, and it substantially decreased IL-9, IRF4, IL-21R, IL-17A, RORγT, TNF-α, and RANTES production but increased GATA3 production in CD8+ T cells. We further observed that MVC treatment decreased IL-9, IL-17A, and RORγt mRNA and protein levels and increased those of GATA3. This study elucidates the capacity of MVC to ameliorate the clinical and histological signs of CIA by reducing pro-inflammatory responses, suggesting that MVC may have novel therapeutic uses in the treatment of RA.  相似文献   
33.
Current research models the Al2O3 47nm and Al2O3 36nm nanoparticles transportation through peristalsis with entropy optimization. Conservation laws for mass, momentum and energy are used to model the present flow situation. These equations elaborates the magnetohydrodynamics, Hall, thermal radiation, Joule heating, heat generation and absorption. Convective heat transfer impacts are studied at channel walls. Entropy is modeled in view of thermodynamics second law. Two different expressions for effective viscosity are accounted. Simplification of the modeled equations is done through lubrication assumptions. Solution for momentum equation is obtained analytically and for numerically for temperature equation. Built-in shooting procedure is utilized to obtain the desired numerical results. Later on these obtained results are used to sketch and discussed the flow quantities of interest for the influential parameters accounted in the problem.  相似文献   
34.
It is shown that at high frequencies matrix elements of the Green's function of a random discrete wave equation decay exponentially at long distances. This is the input to the proof of dense point spectrum with localized eigenfunctions in this frequency range. The proof uses techniques of Fröhlich and Spencer. A sequence of renormalization transformations shows that large regions where wave propagation is easily maintained become increasingly sparse as resonance is approached.  相似文献   
35.
This study proposes the first high-capacity quantum secure direct communication(QSDC) with two-photon six-qubit hyperentangled Bell states in two longitudinal momentum and polarization degrees of freedom(DOFs) of photon pairs, which can be generated using two 0.5 mm-thick type-I β barium borate crystal slabs aligned one behind the other and an eight-hole screen. The secret message can be independently encoded on the photon pairs with 64 unitary operations in all three DOFs. This protocol has a higher capacity than previous QSDC protocols because each photon pair can carry 6 bits of information, not just 2 or 4 bits.Our QSDC protocol decreases the influence of decoherence from environment noise by exploiting the decoy photons to check the security of the transmission of the first photon sequence. Compared with two-way QSDC protocols, our QSDC protocol is immune to an attack by an eavesdropper using Trojan horse attack strategies because it is a one-way quantum communication.The QSDC protocol has good applications in the future quantum communication because of all these features.  相似文献   
36.
Whilst vibration analysis of planetary gearbox faults is relatively well established, the application of Acoustic Emission (AE) to this field is still in its infancy. For planetary-type gearboxes it is more challenging to diagnose bearing faults due to the dynamically changing transmission paths which contribute to masking the vibration signature of interest.  相似文献   
37.
Meyer SA  Faris GW 《Optics letters》1998,23(3):204-206
We report high-power vacuum-ultraviolet (vuv) generation at the Lyman- alpha wavelength of 121.6nm , using a simple experimental system. vuv radiation is produced through two-photon-resonant difference-frequency mixing with a tunable ArF excimer laser and a Nd:YAG-pumped dye laser. Using phase-matched mixtures of Kr and Ar at a total pressure of 650 mbar, we produced 7-microJ energies at Lyman- alpha in approximately 5ns (1.3kW) , as measured directly with a pyroelectric energy probe. Measurements indicate that higher powers are possible with system optimization. A tuning range of 0.1nm was achieved for a fixed gas mole fraction at a total pressure of 650 mbar. Qualitative agreement is found between measured tuning profiles and theoretical predictions.  相似文献   
38.
We report a new approach in tip-enhanced Raman spectroscopy (TERS) in which TERS-active tips with enhancement factors of ~10(-5)× can be rapidly (1-3 min) produced in situ by laser-induced synthesis of silver nanoparticles at the tip apex. The technique minimizes the risks of tip contamination and damage during handling and provides in situ feedback control, which allows the prediction of the tip performance. We show that TERS tips produced by this technique enable the measurement of spatially resolved TERS spectra of self-assembled peptide nanotubes with a spatial resolution of ~20 nm.  相似文献   
39.
Received: 17 June 1998/Revised version: 17 September 1998  相似文献   
40.
Summary A systematic study of the effect of substitution on the thermodynamic stability of the 11 complexes which the UO 2 II ion forms in aqueous media with salicylic acid and ten monosubstituted salicylic acids has been carried out using a new spectrophotometric method. The new features of the method as well as a thermodynamic treatment for the effect of substitution is discussed.  相似文献   
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