Phytochemical Profiling of Lavandula coronopifolia Poir. Aerial Parts Extract and Its Larvicidal,Antibacterial, and Antibiofilm Activity Against Pseudomonas aeruginosa

Infections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of Lavandula coronopifolia aerial parts extract using HPLC–MS/MS led to the tentative identification of 46 compounds belonging to phenolic acids, flavonoids and their glycosides, and biflavonoids. The extract displayed larvicidal activity against Culex pipiens larvae (LC₅₀ = 29.08 µg/mL at 72 h). It significantly inhibited cytochrome P-450 monooxygenase (CYP450), acetylcholinesterase (AChE), and carboxylesterase (CarE) enzymes with the comparable pattern to the control group, which could explain the mode of larvae toxification. The extract also inhibited the biofilm formation of Pseudomonas aeruginosa by 17–38% at different Minimum Inhibitory Concentrations (MICs) (0.5–0.125 mg/mL) while the activity was doubled when combined with ciprofloxacin (ratio = 1:1 v:v). In conclusion, the wild plant, L. coronopifolia, can be considered a promising natural source against resistant bacteria and infectious carriers.     

Investigating microcrystalline cellulose crystallinity using Raman spectroscopy

Cellulose - Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity...     

Nano nickel [1,2,4]-triazole-3-thiones complex: Design,sonochemical synthesis,and antimicrobial evaluation

A series of new 1,2,4-triazole-3-thiones were synthesized by calm, benign, no risk, eco-friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4-triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4-triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X-ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4-triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.     

Structural characteristics of some lanthanide violurate complexes

The magnetic moments and the electronic spectra of violurate complexes of Ce³⁺, Pr³⁺, Pr⁴⁺, Nd³⁺, Sm³⁺, Eu³⁺, Gd³⁺, Ho³⁺, Er³⁺, and Yb³⁺ have been investigated. The solid complexes are paramagnetic and have magnetic moment values near to the ground state values of the free ions. Few cases differ, since there exist possible electronic transitions (4f → 5d) in case of Ce³⁺ complexes and (f → f) for Ho³⁺ and Dy³⁺ complexes. The magnetic measurements in connection with the electronic spectra were used to decide the different electronic structural configuration of elements and hence the configuration of the coordination polyhedra around the central metal ions of the investigated complexes.     

A Nucleophilic Addition of Acetone Enolate to (<Emphasis Type="Italic">E</Emphasis>)-Alkyloxindolylideneacetates

Summary. The reaction of (E)-(2-oxo-1,2-dihydroindol-3-ylidene)acetic acid esters with dry acetone at 70°C in presence of aluminum oxide as a catalyst led to the formation of an addition product as a mixture of two isomers. When the same reaction was carried out in presence of morpholine as a base, the unexpected spiro-product was obtained beside the two isomers. Methylation of the latter with methyl iodide in acetone in presence of anhydrous potassium carbonate yielded the corresponding methylated products, whereas methylation of the starting material by the same procedure gave an N-methylated product and the unexpected dispiro-compound. The reaction mechanisms are considered and the structural assignments of the new compounds are based on the chemical and spectroscopic evidences. The structure of the dispiro-product was derived by X-ray analysis.     

Galerkin Approximations for the Linear Parabolic Equation with the Third Boundary Condition

We solve a linear parabolic equation in ^d , d 1, with the third nonhomogeneous boundary condition using the finite element method for discretization in space, and the -method for discretization in time. The convergence of both, the semidiscrete approximations and the fully discretized ones, is analysed. The proofs are based on a generalization of the idea of the elliptic projection. The rate of convergence is derived also for variable time step-sizes.     

Indirect determination of pilocarpine by atomic absorption spectrometry

Atomic absorption spectroscopic (AAS) method for microdetermination of pilocarpine alkaloid has been developed. The procedure is based upon the measurement of mercuric content of pilocarpine complex. The experimental conditions as well as the molar ratio were thoroughly studied. The percentage recovery of pilocarpine was found to be (99.15 ± 0.79). The proposed method was applied on pharmaceutical formulations and the results were satisfactory and in good agreement with that given by the official one.     

Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies

Molecular Diversity - The discovery of potent STAT3 inhibitors has gained noteworthy impetus in the last decade. In line with this trend, considering the proven biological importance of...     

Kinetics and mechanism of oxidation of N,N-bis(salicylaldehyde-1,2-diaminoethane) cobalt(II) by N-bromosuccinimide in aqueous acidic medium

The kinetics of oxidation of N,N-bis(salicylaldehyde-1,2-diaminoethane) cobalt(II) complex by N-bromosuccinimide (NBS) in aqueous acid and H₂O–MeOH solvent mixtures were studied spectrophotometrically over the 20–40 °C range, 0.1–0.5 mol dm^?3 ionic strength, 2.2–2.8 pH range and 0–40 wt% MeOH–H₂O solvent mixtures for a range of NBS and complex concentrations. The rate shows first-order dependence on both [NBS] and [complex] and decreases with pH over the range studied. The protonated form of N-bromosuccinimide was identified as the main reactive species. An inner-sphere mechanism involving free radicals is proposed.