In vitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells

There are four kinds of Cedar: Cedrus libani naturally occurring in Lebanon, Syria and Turkey, Cedrus atlantica in Morocco and Algeria, Cedrus brevefolia in Cyprus Island and Cedrus deodara which is distributed in Himalayan Mountains. Wood essential oils obtained from C. libani, C. atlantica and C. deodara were tested for the inhibition of K562 cell proliferation and for the induction of erythroid differentiation. The wood essential oils of C. libani, C. atlantica and C. deodara inhibited the proliferation of the K562 cell line exhibiting IC(50) values 23.38?±?1.7, 59.37?±?2.6 and 37.09?±?1.4?μg?mL(-1), respectively. Meanwhile, C. libani wood oils induced a percentage of erythroid differentiation of 15?±?2% at concentration 5?μg?mL(-1). Cedrus deodara wood oil indicated a percentage of erythroid differentiation of 20?±?2% at concentration 25?μg?mL(-1) and C. atlantica wood oils showed a percentage of erythroid differentiation of 12?±?1.8% at concentration 10?μg?mL(-1).     

Preparation and structural characterization of tetracoordinated tungsten(II) diazadiene complexes

Reduction in situ of WCl₄(MeCN)₂ with zinc in the presence of diazadiene ligands 1b-f is reported and produces a series of diamagnetic complexes (DAD)WCl₂2b-f. All complexes were characterized by ¹H, ¹³C NMR and IR spectroscopic data. The crystal structures of complexes 2b and 2e were solved by X-ray diffraction methods.     

Synthesis and characterization of a new hexacyclic helicene

A new helically chiral hexacyclic system, bearing an acetoxymethyl group, was prepared from a simple naphthalene building block in good yield and purity, via a four-step sequence involving palladium-catalysed Heck couplings and oxidative photocyclizations. Suitable crystals of the latter indicate that its conformation closely resembles that of unsubstituted [6]helicene, whose idealized symmetry is C₂. The optical properties of the hexacyclic helicene were investigated and show interesting behaviour.     

Synthesis, characterization, and conformational analysis of new perfunctionalized calix[9]arenes

The synthesis of a series of six new per-substituted p-tert-butylcalix[9]arenes derivatives has been achieved. Functions such as ester, nitrile, or carbonate have been grafted on the phenolic oxygens of calix[9]arene: p-tert-butylcalix[9]arene nona-ethyl acetate, p-tert-butylcalix[9]arene nona-carboxylic acid, p-tert-butylcalix[9]arene nona-cyanopropyloxy, p-tert-butylcalix[9]arene nona-tert-butoxycarbonyle, p-tert-butylcalix[9]arene nona-acetyl, and p-tert-butylcalix[9]arene nona-trifluoroacetyl have been obtained in good yields (from 48% to 78%) and fully characterized. The X-ray structures of p-tert-butylcalix[9]arene nona-tert-butoxycarbonyl and p-tert-butylcalix[9]arene nona-ethyl acetate have been determined. A dynamic NMR study has revealed the high conformational mobility of such structures, even at low temperature.     

Synthesis and X-ray structure of cationic β-diimine palladium complexes containing π-methallyl ligand

High yield of cationic palladium β-diimine complexes [(CH₂(MeCNAr)₂)Pd(η³-C₄H₇)][Y] (Ar = C₆H₅, Y = PF₆ (8); 2-Me-C₆H₄, Y = PF₆ (9); 2,6-Me₂-C₆H₃, Y = PF₆ (10); 2,6-iPr₂-C₆H₃, Y = PF₆ (11), Y = B(3,5-(CF₃)₂-C₆H₃)₄ (12)) have been obtained by an oxidative addition of the methallyloxyphosphonium salts (5, 6) to a preformed complex Pd(dba)₂ (7) in the presence of the β-iminoamine ligands (1-4).These complexes are thermally stable and have been characterized by ¹H and ¹³C{¹H} NMR as well as IR spectroscopy. The structure of the cationic allyl palladium complex (12) has been solved by X-ray crystallography.     

Selective functionalization of crown ethers via arene chromium tricarbonyl complexes

The crown ethers dibenzo-16-crown-4 and dibenzo-18-crown-5 and a diaryl polyether were complexed by the chromium tricarbonyl group for the purpose of selective functionalization. This complexation did indeed permit exclusive functionalization of the complexed ring. CHO and CH₂OH functionalities were introduced ortho to the ether group. It was noted that the nature of the two ether chains had a strong influence on the regioselectivity of the functionalization, which occurred preferentially on the side with the polyether chain. Photochemical decomplexation produced functionalized organic crown ethers.     

Magnetic Nitrogen-Doped Porous Carbon Nanocomposite for Pb(II) Adsorption from Aqueous Solution

We report in the present study the in situ formation of magnetic nanoparticles (Fe₃O₄ or Fe) within porous N-doped carbon (Fe₃O₄/N@C) via simple impregnation, polymerization, and calcination sequentially. The synthesized nanocomposite structural properties were investigated using different techniques showing its good construction. The formed nanocomposite showed a saturation magnetization (M_s) of 23.0 emu g⁻¹ due to the implanted magnetic nanoparticles and high surface area from the porous N-doped carbon. The nanocomposite was formed as graphite-type layers. The well-synthesized nanocomposite showed a high adsorption affinity toward Pb²⁺ toxic ions. The nanosorbent showed a maximum adsorption capacity of 250.0 mg/g toward the Pb²⁺ metallic ions at pH of 5.5, initial Pb²⁺ concentration of 180.0 mg/L, and room temperature. Due to its superparamagnetic characteristics, an external magnet was used for the fast separation of the nanocomposite. This enabled the study of the nanocomposite reusability toward Pb²⁺ ions, showing good chemical stability even after six cycles. Subsequently, Fe₃O₄/N@C nanocomposite was shown to have excellent efficiency for the removal of toxic Pb²⁺ ions from water.     

Na2Co(H2PO4)4·4H2O

In the title compound, disodium cobalt tetrakis­(dihydrogen­phosphate) tetrahydrate, the Co^II ion lies on an inversion centre and is octahedrally surrounded by two water molecules and four H₂PO₄ groups to give a cobalt complex anion of the form [Co(H₂PO₄)₄(OH₂)]^2?. The three‐dimensional framework results from hydrogen bonding between the anions. The relationship with the structures of Co(H₂PO₄)₂·2H₂O and K₂CoP₄O₁₂·5H₂O is discussed.     

Effect of carriers localized in clusters on optical properties of In0.21Ga0.79As/GaAs multiple quantum wells

In_0.21Ga_0.79As multiple quantum wells MQW, with different well thickness L, are grown on [001] and [113] A GaAs growth directions by molecular beam epitaxy MBE. An asymmetric photoluminescence PL line shape denoted LE_A and LE_B in the lower energies side has been observed in both structures. These emissions of deep localized states can be related to the energy potential modulation associated to Indium cluster formation. Temperature dependence of photoluminescence properties has been reported. Localized state ensemble LSE model has investigated atypical behaviors of PL peak energies and the full width at half maximum FWHM of both emissions. These abnormal behaviors are explained by carriers captured by localized recombination centers. Competition processes between localized and delocalized excitons have been occurred to interpret the PL properties. The degree of localization induced by quantum-dot-like states and critical temperatures between different temperatures regions increase as far as away [001] growth direction.