不同因素对可调节人工晶体屈光调节力的影响

首先以Hwey-Lan Liou眼模型为基础，根据等效性原则，保持该眼模型中自然晶状体屈光度不变，对无穷远点成像。然后利用ZEMAX实现光线追迹的方法，将自然晶状体替换为可调节人工晶状体（accommodative intraocular lens，AIOL），结合对人眼成像质量影响的分析，研究了AIOL在眼内的移动度、材料、中心厚度、结构、光学面非球面性等因素对其屈光调节力的影响。结果表明:AIOL移动度对其调节力贡献最大,材料、中心厚度、结构对调节力基本无影响；具有非球面光学面的AIOL调节力相对较大。     

无线传感器网络中继节点布居算法的研究

本文表述的是在该应用背景下引入多约束条件, 并采用枚举法与贪婪寻优算法相结合的方法, 解决了在可以作为中继节点设置位置的预设中继节点位置集合内, 合理选择中继节点设置位置以及既存网络因添加新传感器节点所引起的中继节点追加的问题. 仿真实验表明, 本文提出的中继节点布居与追加优化算法能够保证多约束条件下网络的容错性. 同时提出的基于最小网络距离因子评价标准, 有效提高了中继节点布居算法的能效性.     

复杂混合溶液成分高光谱分析的可行性

采用高光谱技术对复杂混合溶液进行检测分析,同时利用被测物质的吸光度和散射特性信息以提高光谱的信噪比。实验设计了高光谱采集装置,采集生物组织模拟液(Intralipid-10%)的漫反射高光谱图像,并用Monte Carlo方法和漫射近似理论对其进行了正向和反向推导,获得了632nm波长下,Intralipid-10%吸收系数为0.002 0cm-1,与标准参数相对误差为11.1%;约化散射系数为63.35cm-1,与标准参数相对误差为6.49%,基本符合标准参数的误差范围,验证了该高光谱检测系统的准确性。还利用该高光谱系统对不同厂家出品的牛奶、果汁等样本进行了高光谱采集,得到不同样本间差异较传统二维光谱更为明显的结果,充分证明了高光谱方法在复杂混合溶液成分分析中具有很强的可行性。     

CPA方程计算醇+卤代烃体系气液相平衡

醇+卤代烃混合体系,尤其是乙醇、三氟乙醇(TFE)等与卤代烃的混合工质在吸收式制冷、热泵、蒸气动力循环等领域中有着重要的应用.CPA方程可以描述缔合流体的性质,用于含醇类组元的混合体系气液相平衡性质描述.本文首先从纯物质饱和性质实验数据回归得到了CPA方程参数;将CPA方程应用于醇+卤代烃混合体系的气液相平衡计算,采用并比较了2种缔合方案;比较了CPA方程与G~E-EoS模型的相平衡计算效果.CPA状态方程在揭示分子间相互作用的基础上可准确描述醇+卤代烃混合体系的气液相平衡性质.     

Photocatalytic degradation of methyl orange by nano-TiO_2 thin films prepared by RF magnetron sputtering

Nano-TiO2 thin films are deposited by radio frequency （RF） magnetron sputtering using TiO2 ceramic target and characterized by X-ray diffractometer, atomic force microscope, and ultraviolet-visible spectrophotometer. The photocatalytic activity is evaluated by light-induced degradation of methyl orange solutions （5, 10, and 20 ppm） using a high pressure mercury lamp as the light source. The film is amorphous, and its energy gap is 3.02 eV. The photocatalytic degradation of methyl orange solution is the first-order reaction and the apparent reaction rate constants are 0.00369, 0.0024, and 0.00151 for the methyl orange solution concentrations of 5, 10, and 20 ppm, respectively.     

Perturbation to Mei Symmetry and Adiabatic Invariants for Nonholonomic Systems in Terms of Quasi-Coordinates

Based on the concept of adiabatic invariant, the perturbation to Meisymmetry and adiabatic invariants for nonholonomic mechanical systems interms of quasi-coordinates are studied. The definition of the perturbationto Mei symmetry for the system is presented, and the criterion of theperturbation to Mei symmetry is given. Meanwhile, the Mei adiabaticinvariants for the perturbed system are obtained.     

Prominin‐1‐Specific Binding Peptide‐Modified Apoferritin Nanoparticle Carrying Irinotecan as a Novel Radiosensitizer for Colorectal Cancer Stem‐Like Cells

Resistance of cancer stem cells to radiotherapy remains a major obstacle to successful cancer management. Prominin‐1 (PROM1) is a cancer stem cell marker. Nanoparticle (NP) chemotherapeutics preferentially accumulate in tumors and are able to target cancer and cancer stem‐like cells through cancer cell‐specific ligands, making them uniquely suited as radiosensitizers for chemoradiation therapy. Using a biocompatible apoferritin NP, a PROM1‐targeted NP carrying irinotecan (PROM1‐NP) is engineered. The synergistic effect of the NP and irradiation is evaluated in PROM1‐overexpressing HCT‐116 colorectal cancer cell lines in vitro and in vivo. PROM1‐NP has a size of 17.2 ± 0.2 nm and surface charge of ?13.5 ± 0.2 mV. It demonstrates higher intracellular uptake than nontargeted NP or irinotecan alone. Treatment with PROM1‐NPs decreases HCT‐116 cell proliferation in a dose‐ and time‐dependent manner. In vitro radiosensitization reveals that PROM1‐NP is significantly more effective as a radiosensitizer than nontargeted NP or irinotecan. HCT‐116 tumor xenograft growth is markedly slower following treatment with PROM1‐NP plus irradiation, suggesting that PROM1‐NP is more effective as a radiosensitizer than irinotecan and nontargeted NP in vivo. This study provides the first preclinical evidence of the effectiveness of PROM1‐targeted NP formulation of irinotecan as a radiosensitizer.     

An in silico protocol for identifying mTOR inhibitors from natural products

The mammalian target of rapamycin (mTOR) is an anti-cancer target. In this study, we propose an in silico protocol for identifying mTOR inhibitors from the ZINC natural product database. First, a three-dimensional quantitative structure–activity relationship pharmacophore model was built based on known mTOR inhibitors. The model was validated with an external test set, Fischer’s randomization method, a decoy set and pharmacophore mapping conformation testing. The results showed that the model can predict the mTOR inhibition activity of the tested compounds. Virtual screening was performed based on the best pharmacophore model, and the results were then filtered using a molecular docking approach. In addition, molecular mechanics/generalized born surface area analysis was used to refine the selected candidates. The top 20 natural products were selected as potential mTOR inhibitors, and their structural scaffolds could serve as building blocks in designing drug-like molecules for mTOR inhibition.     

化学气相沉积法制备Zn2GeO4纳米线及其发光性质的研究

利用化学气相沉积法（CVD）,气-液-固（VLS）生长法则在表面溅有金属Au催化剂层的1 cm×1 cm的Si片上制备三元Zn₂GeO₄纳米线。X射线衍射仪（XRD）测试结果表明,锌源与锗源质量比为8：1时可成功制备出Zn₂GeO₄纳米结构;扫描电子显微镜（SEM）测试结果表明,Zn₂GeO₄纳米线直径为100 nm,长度为10~11 μm;光致发光（PL）测试结果表明,Zn₂GeO₄纳米线在432和480 nm处具有两个发光峰,最后对其生长机理进行了分析。     

非晶InGaZnO薄膜晶体管驱动OLED像素电路的仿真研究

为解决非晶InGaZnO薄膜晶体管(a-IGZO TFT)因其阈值电压漂移而导致的OLED电流衰减的问题,本文研究了基于a-IGZO TFT的有源矩阵有机发光显示(AMOLED)像素电路的阈值电压补偿问题。利用实验室制备的a-IGZO TFT器件进行参数提取后建立的SPICE仿真模型并进行仿真计算,对电压驱动型2T1C和4T1C的像素电路进行稳定性的比较研究,证明了4T1C电路对阈值漂移有非常好的补偿效果,并指出增加存储电容值和驱动TFT的宽长比可有效提高OLED电流的保持能力。