The microtubule associated protein tau is the principle component of neurofibrillar tangles, which are a characteristic marker
in the pathology of Alzheimer's disease; similar lesions are also observed after chronic alcohol abuse. Formaldehyde is a
common environmental contaminant and also a metabolite of methanol. Although many studies have been done on methanol and formaldehyde
intoxication, none of these address the contribution of protein misfolding to the pathological mechanism, in particular the
effect of formaldehyde on protein conformation and polymerization. 相似文献
Room-temperature Ionic Liquids(ILs) have numerous unique properties that differ from those of conventional molecular solvents.Although the unique properties of ILs have been suggested to origin from their microscopic interionic interaction,detailed dynamics of interionic interaction of ILs has not been fully understood.Here,with the Femtosecond Optical Heterodyne-Detected Raman Induced Kerr Effect Spectroscopy(fs-OHD-RIKES),we measured the ultrafast dynamics of the interionic interaction of three typical im... 相似文献
The titania monolith column has been synthesized through a template-free sol–gel route, and a simple and reliable method for the determination of benzoic acid by hydrophilic interaction liquid chromatography using the prepared titania monolith has been developed. The influences of acetonitrile, acetate buffer and buffer pH on the retention of benzoic acid were investigated. Benzoic acid in carbonated drinks and fruit beverages samples were determined within 5 min and quantitative analysis was carried out by external standard method with a correlation coefficient (R2) of 0.9984. The relative standard deviation was 0.91 % and the recovery ranged from 92.5 to 101.3 %. The proposed method is suitable for the analysis of benzoic acid in beverage samples.
Although they are simple techniques from the early days of timetabling research, graph colouring heuristics are still attracting
significant research interest in the timetabling research community. These heuristics involve simple ordering strategies to
first select and colour those vertices that are most likely to cause trouble if deferred until later. Most of this work used
a single heuristic to measure the difficulty of a vertex. Relatively less attention has been paid to select an appropriate
colour for the selected vertex. Some recent work has demonstrated the superiority of combining a number of different heuristics
for vertex and colour selection. In this paper, we explore this direction and introduce a new strategy of using linear combinations
of heuristics for weighted graphs which model the timetabling problems under consideration. The weights of the heuristic combinations
define specific roles that each simple heuristic contributes to the process of ordering vertices. We include specific explanations
for the design of our strategy and present the experimental results on a set of benchmark real world examination timetabling
problem instances. New best results for several instances have been obtained using this method when compared with other constructive
methods applied to this benchmark dataset. 相似文献
The purpose of this paper is to study the dynamic behavior of soft ground including a porous layer by considering the porosity
change. In order to take the porosity change into account, the concept of the volume fraction, which has been proposed in
continuum mechanics, is introduced. The constitutive equations presented by Bowen are applied to the analysis of the porous
media. According to Bowen's theory, the porosity is considered as a variable called the volume fraction and has its own constitutive
equation. The constitutive equation of the volume fraction has thermoelastic equation coefficients and is determined by the
strains of the solid and the fluid. This means that the compressibilities of the solid and the fluid are considered. When
the special condition is assumed, Bowen's theory can contain Biots's theory, which has been applied in earthquake engineering.
The wave propagation in the ground including a porous layer, modeled by Bowen's theory, is studied and compared with that
of Biot's theory. One-dimensional attenuation and surface amplitude are calculated. The effect of the volume fraction is discussed
with respect to the compressibilities of the solid and the fluid. 相似文献