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151.
Alon Ben David Eran Diamant Eyal Dor Ada Barnea Niva Natan Lilach Levin Shira Chapman Lilach Cherry Mimran Eyal Epstein Ran Zichel Amram Torgeman 《Molecules (Basel, Switzerland)》2021,26(11)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global pandemic. The first step of viral infection is cell attachment, which is mediated by the binding of the SARS-CoV-2 receptor binding domain (RBD), part of the virus spike protein, to human angiotensin-converting enzyme 2 (ACE2). Therefore, drug repurposing to discover RBD-ACE2 binding inhibitors may provide a rapid and safe approach for COVID-19 therapy. Here, we describe the development of an in vitro RBD-ACE2 binding assay and its application to identify inhibitors of the interaction of the SARS-CoV-2 RBD to ACE2 by the high-throughput screening of two compound libraries (LOPAC®1280 and DiscoveryProbeTM). Three compounds, heparin sodium, aurintricarboxylic acid (ATA), and ellagic acid, were found to exert an effective binding inhibition, with IC50 values ranging from 0.6 to 5.5 µg/mL. A plaque reduction assay in Vero E6 cells infected with a SARS-CoV-2 surrogate virus confirmed the inhibition efficacy of heparin sodium and ATA. Molecular docking analysis located potential binding sites of these compounds in the RBD. In light of these findings, the screening system described herein can be applied to other drug libraries to discover potent SARS-CoV-2 inhibitors. 相似文献
152.
The effect of recrystallization temperature on the lamellar structure of RSIII samples was studied using XRD and SAXS. The polymorph type could be manipulated in a controlled manner, independently of the plant source. In RSIII from corn starch and from high-amylose corn starch, retrogradation at a low temperature led to the formation of polymorph B with lamellas arranged in long-range periodicity, whereas retrogradation at a high temperature led to the formation of polymorphs A and V with no defined periodicity. The retrogradation temperature of wheat starch did not have a major effect on its nanostructure. For both polymorphs, the enzymatic degradation decreased as the degree of order within the crystal increased. 相似文献
153.
Elish Eyal Brandis Michal Haquin Gustavo Hershko Itzhak Yungrais Zohar Aviv Ofer Moyal Amiram Assulin Maor Nawi Yehuda Solomon Oren Zakon Yevgeni Rubinshtein Arnon Astrachan Boaz 《Journal of Radioanalytical and Nuclear Chemistry》2021,329(1):51-60
Journal of Radioanalytical and Nuclear Chemistry - An orphan radium-beryllium (Ra–Be) neutron source (Nuclear Chicago Corporation) detected inside a scrap metal shipping container, was seized... 相似文献
154.
Prof. Luciano De Sio Prof. Bin Ding Dr. Monica Focsan Prof. Karin Kogermann Prof. Paula Pascoal-Faria Dr. Francesca Petronela Prof. Geoffrey Mitchell Prof. Eyal Zussman Prof. Filippo Pierini 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(20):6112-6130
The Coronavirus disease 2019 (COVID-19) emergency has demonstrated that the utilization of face masks plays a critical role in limiting the outbreak. Healthcare professionals utilize masks all day long without replacing them very frequently, thus representing a source of cross-infection for patients and themselves. Nanotechnology is a powerful tool with the capability to produce nanomaterials with unique physicochemical and antipathogen properties. Here, how to realize non-disposable and highly comfortable respirators with light-triggered self-disinfection ability by bridging bioactive nanofiber properties and stimuli-responsive nanomaterials is outlined. The visionary road highlighted in this Concept is based on the possibility of developing a new generation of masks based on multifunctional membranes where the presence of nanoclusters and plasmonic nanoparticles arranged in a hierarchical structure enables the realization of a chemically driven and on-demand antipathogen activities. Multilayer electrospun membranes have the ability to dissipate humidity present within the mask, enhancing the wearability and usability. The photothermal disinfected membrane is the core of these 3D printed and reusable masks with moisture pump capability. Personalized face masks with smart nano-assisted destruction of pathogens will bring enormous advantages to the entire global community, especially for front-line personnel, and will open up great opportunities for innovative medical applications. 相似文献
155.
156.
The goal of the matrix completion problem is to retrieve an unknown real matrix from a small subset of its entries. This problem comes up in many application areas, and has received a great deal of attention in the context of the Netflix challenge. This setup usually represents our partial knowledge of some information domain. Unknown entries may be due to the unavailability of some relevant experimental data. One approach to this problem starts by selecting a complexity measure of matrices, such as rank or trace norm. The corresponding algorithm outputs a matrix of lowest possible complexity that agrees with the partially specified matrix. The performance of the above algorithm under the assumption that the revealed entries are sampled randomly has received considerable attention (e.g., Refs. Srebro et al., 2005; COLT, 2005; Foygel and Srebro, 2011; Candes and Tao, 2010; Recht, 2009; Keshavan et al., 2010; Koltchinskii et al., 2010). Here we ask what can be said if the observed entries are chosen deterministically. We prove generalization error bounds for such deterministic algorithms, that resemble the results of Refs. Srebro et al. (2005); COLT (2005); Foygel and Srebro (2011) for the randomized algorithms. We still do not understand which sets of entries in a given matrix can be used to properly reconstruct it. Our hope is that the present work sheds some light on this problem. © 2013 Wiley Periodicals, Inc. Random Struct. Alg., 45, 306–317, 2014 相似文献
157.
Relaxation spectra of polymers and phenomena of electrical and hydrophobic recovery: Interplay between bulk and surface properties of polymers
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Roman Pogreb Ron Loew Edward Bormashenko Gene Whyman Victor Multanen Evgeny Shulzinger Amir Abramovich Daniel Rozban Alexander Shulzinger Eyal Zussman Arkadii Arinstein Gleb Vasilyev Alexander Ya. Malkin 《Journal of Polymer Science.Polymer Physics》2017,55(2):198-205
Low‐density polyethylene, polypropylene, and polycarbonate were exposed to cold air plasma treatment. The decay of electret response, hydrophobic recovery, and mechanical relaxation of polymers were studied experimentally. The three‐exponential decay kinetic model was used for the treatment of mechanical and electret responses. The characteristic time scales of mechanical and electret responses turned out to be very close. The “longest” relaxation time, extracted from the experimental study of the hydrophobic recovery, was also close to the corresponding characteristic time spans of electret and mechanical responses. The kinetics of surface processes taking place in polymers is controlled by the mobility of their functional groups, represented by the bulk relaxation spectra. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017 , 55, 198–205 相似文献
158.
Self-immolative dendrimers disassemble through a domino-like chain fragmentation initiated by a single cleavage at the dendrimer core. We have designed and synthesized dendritic molecules that resemble dendritic architectures present in nature. The unique design allows a cleavage signal received by any one of the multiple triggers on one side of the dendrimer to be transferred convergently to a focal point. The signal is divergently amplified through to the other side of the dendrimer, reporter units are released, and fluorescence is emitted. During signal propagation, the dendritic molecule disassembles in a self-immolative manner into small fragments. These compounds are the longest dendritic system ever reported to disassemble through sequential self-immolative reactions. The synthesized dendritic molecules have an architecture and signal-conducting activity related to that of neurons. 相似文献
159.
Klerman Y Ben-Ari E Diskin-Posner Y Leitus G Shimon LJ Ben-David Y Milstein D 《Dalton transactions (Cambridge, England : 2003)》2008,(24):3226-3234
The cationic, pincer-type complexes [(SNS)Ir(COE)][BF4] (1) and [(SNS)Rh(COE)][BF4] (2) (SNS = 2,6-bis(t-butylthiomethy1)pyridine; COE = cyclooctene) complexes were prepared, and their structure and reactivity were studied. They are fluxional at room temperature as a result of "arm" hemilability, which can be frozen at low temperatures. Reaction of complex 1 with H2 resulted in a dimeric dihydride complex [(SNS)Ir(H2)]2[BF4]2 (3) in which the sulfur atoms bridge between two metal centers. The Rh complex 2 did not react with H2. Both the carbonyl complexes [(SNS)Ir(CO)][BF4] (5) and [(SNS)Rh(CO)][BF4] (6) show differences in the IR stretching frequencies in solution vs. solid states, which are a result of uncommon metal-metal interactions between square planar d8 systems in the solid state. Complexes 1, 3, 5 and 6 were structurally characterized by X-ray crystallography. A network of hydrogen bonds involving the BF4(-) counter anion and hydrogen atoms of complex 5 was observed. 相似文献
160.
Using a tetradentate, dianionic ligand several new zirconium complexes have been prepared. These pyrrolyl compounds, unlike their titanium analogues, are inactive in hydrohydrazination catalysis. However, they are quite stable, and their reactivity with H2NR, where R = Ph, C6H11, and NHPh, is reported here. Two of the complexes were characterized by X-ray diffraction. 相似文献