The role of CO in CO2 lasers

The population inversion in a CO₂-He glow discharge has been calculated, taking into account CO produced by dissociation in the discharge. The calculation was based on experimentally determined electron energy distributions and the measured effective relaxation constant of CO₂ (001). It is shown that the population inversion is negligible in the absence of CO.     

Dynamic spin relaxation processes of μ+ in an antiferromagnet

A new mechanism for positive muon spin-lattice relaxation (SLR) in an antiferromagnet is described. The temperature dependence of the relaxation rate (1/T ₁) is calculated in a simplified case, and SLR of muon in MnF₂ is studied in the context of this model.The author wishes to thank: S. R. Kreitzman and J. Shaham for their encouragement and stimulating ideas; L. P. Le, G. M. Luke, W. D. Wu, and Y. J. Uemura for helpful discussions.     

Ga NMR study of the local susceptibility in Kagome-based SrCr8Ga4O19: pseudogap and paramagnetic defects

We present the first Ga(4f ) NMR study of the Cr susceptibility in the archetype of kagome-based frustrated antiferromagnets, SrCr8Ga4O19. Our major finding is that the susceptibility of the frustrated lattice goes through a maximum around 50 K. Our data also support the existence of paramagnetic "clusters" of spins, responsible for the Curie behavior observed in the macroscopic susceptibility at low T. These results set novel features for the constantly debated physics of geometrically frustrated magnets.     

Magnetic dilution in the geometrically frustrated SrCr(9p)Ga(12-9p)O19 and the role of local dynamics: A muon spin relaxation study

We investigate the spin dynamics of SrCr(9p)Ga(12-9p)O19 for p below and above the percolation threshold p(c) using muon spin relaxation. Our major findings are as follows: (i) At T-->0 the relaxation rate is T independent and approximately p(3), (ii) the slowing down of spin fluctuation is activated with an energy U, which is also a linear function of p(3) and lim U as p-->0 = 8 K; this energy scale could stem only from a single ion anisotropy, and (iii) the p dependence of the dynamical properties is identical below and above p(c), indicating that they are controlled by local excitation.     

Applying reproducing kernels to the evaluation and approximation of the simple and time-dependent imaginary time harmonic oscillator path integrals

Reproduction of kernel Hilbert spaces offers an attractive setting for imaginary time path integrals, since they allow to naturally define a probability on the space of paths, which is equal to the probability associated with the paths in Feynman's path integral formulation. This study shows that if the propagator is Gaussian, its variance equals the squared norm of a linear functional on the space of paths. This can be used to rederive the harmonic oscillator propagator, as well as to offer a finite-dimensional perturbative approximation scheme for the time-dependent oscillator wave function and its ground state energy, and its bound error. The error is related to the rate of decay of the Fourier coefficients of the time-dependent part of the potential. When the rate of decay increases beyond a certain threshold, the error in the approximation over a subspace of dimension n is of order (1/n ³).     

Rapid identification of bacteria with a disposable colorimetric sensing array

Rapid identification of both species and even specific strains of human pathogenic bacteria grown on standard agar has been achieved from the volatiles they produce using a disposable colorimetric sensor array in a Petri dish imaged with an inexpensive scanner. All 10 strains of bacteria tested, including Enterococcus faecalis and Staphylococcus aureus and their antibiotic-resistant forms, were identified with 98.8% accuracy within 10 h, a clinically important time frame. Furthermore, the colorimetric sensor arrays also proved useful as a simple research tool for the study of bacterial metabolism and as an easy method for the optimization of bacterial production of fine chemicals or other fermentation processes.     

Targeted therapy of the insulin-like growth factor-1 receptor in cancer

Recently, significant progress has been made towards understanding the pathogenesis of cancer from the molecular standpoint. To this end, a growing number of approaches are being exploited for the identification and validation of new therapeutic targets suitable for potent and specific intervention. The type 1 insulin-like growth factor receptor (IGF-1R) system has recently become the focus of major attention in the arena of cancer research. The involvement of the receptor and its downstream signaling cascades in the carcinogenesis process makes this system an excellent target for potential cancer therapy. Indeed, advances in the understanding of the molecular mechanisms behind IGF-1R activation have led to the discovery of agents designed selectively for targeting IGF-1R. The potential application of these inhibitors is currently under intense clinical investigation. This review describes the biology of IGF-1R particularly from a cancer perspective. The attempts to develop effective IGF-1R antagonists are discussed comprehensively with special emphasis on antibodies and small tyrosine kinase inhibitors.     

Entropic attraction condenses like-charged interfaces composed of self-assembled molecules

Like-charged solid interfaces repel and separate from one another as much as possible. Charged interfaces composed of self-assembled charged-molecules such as lipids or proteins are ubiquitous. The present study shows that although charged lipid-membranes are sufficiently rigid, in order to swell as much as possible, they deviate markedly from the behavior of typical like-charged solids when diluted below a critical concentration (ca. 15 wt %). Unexpectedly, they swell into lamellar structures with spacing that is up to four times shorter than the layers should assume (if filling the entire available space). This process is reversible with respect to changing the lipid concentration. Additionally, the research shows that, although the repulsion between charged interfaces increases with temperature, like-charged membranes, remarkably, condense with increasing temperature. This effect is also shown to be reversible. Our findings hold for a wide range of conditions including varying membrane charge density, bending rigidity, salt concentration, and conditions of typical living systems. We attribute the limited swelling and condensation of the net repulsive interfaces to their self-assembled character. Unlike solids, membranes can rearrange to gain an effective entropic attraction, which increases with temperature and compensates for the work required for condensing the bilayers. Our findings provide new insight into the thermodynamics and self-organization of like-charged interfaces composed of self-assembled molecules such as charged biomaterials and supramolecular assemblies that are widely found in synthetic and natural constructs.     

Selective Terminal Functionalization of Linear Alkanes**

A two-step sequential strategy involving a biocatalytic dehydrogenation/remote hydrofunctionalization, as a unified and versatile approach to selectively convert linear alkanes into a large array of valuable functionalized aliphatic derivatives is reported. The dehydrogenation is carried out by a mutant strain of a bacteria Rhodococcus and the produced alkenes are subsequently engaged in a remote functionalization through a metal-catalyzed hydrometalation/migration sequence that subsequently react with a large variety of electrophiles. The judicious implementation of this combined biocatalytic and organometallic approach enabled us to develop a high-yielding protocol to site-selectively functionalize unreactive primary C−H bonds.