排序方式: 共有15条查询结果,搜索用时 31 毫秒
11.
Synthesis,Characterization, and Anticancer Potency of Branched Poly (p-Hydroxy Styrene) Schiff-Bases
El-Refaie Kenawy Sahar H. El-Khalafy Hamed A. Abosharaf Esraa M. El-nshar Ahmed R. Ghazy Mohamed M. Azaam 《Macromolecular bioscience》2023,23(11):2300090
A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) are created. The branched polymer is first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes are reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR, and elemental analysis, all synthesized Schiff-bases are identified and characterized. Further, the antineoplastic potential of all Schiff bases is evaluated against different cancer cell lines. The results gained from this study indicate that the Schiff base polymers have cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency is dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer shows potent cytotoxicity and is able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulates VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. 相似文献
12.
Adnan S. Abu-Surrah Hamzeh M. Abdel-Halim Hebah A. N. Abu-Shehab Esraa Al-Ramahi 《Transition Metal Chemistry》2017,42(2):117-122
The synthesis and characterization of substituted ONNO-donor salen-type Schiff base complexes of general formula [MIII(L)Cl] (L = Schiff base ligand, M = Fe, Co) is reported. The complexes have been applied as catalysts for the coupling of carbon dioxide and styrene oxide in the presence of tetrabutylammonium bromide as a co-catalyst. The reactions were carried out under relatively low-pressure and solvent-free conditions. The effects of the metal center, ligands, and various substituents on the peripheral sites of the ligand on the coupling reaction were investigated. The catalyst systems were found to be selective for the coupling of CO2 and styrene oxide, resulting in cyclic styrene carbonate. The cobalt(III) complex with no substituents on the ligand showed higher activity (TON = 1297) than the corresponding iron(III) complex (TON = 814); however, the iron(III)-based catalysts bearing electron-withdrawing substituents on the salen ligands (NEt3, TON = 1732) showed the highest catalytic activity under similar reaction conditions. The activity of one of the cobalt(III) complexes toward the coupling of 1-butene oxide, cyclohexene oxide and propylene oxide with CO2 was evaluated, revealing a notable activity for the coupling of 1-butene oxide. 相似文献
13.
Tahani M. Almutairi Nadjet Rezki Mohamed Reda Aouad Mohamed Hagar Basant A. Bakr Moaaz T. Hamed Maha Khairy Hassen Bassma H. Elwakil Esraa Abdelhamid Moneer 《Molecules (Basel, Switzerland)》2022,27(7)
Nitrogen-containing atoms in their core structures have been exclusive building blocks in drug discovery and development. One of the most significant and well-known heterocycles is the 1,3,4-thidiazole nucleus, which is found in a wide range of natural products and therapeutic agents. In the present work, certain tris-1,3,4-thiadiazole derivatives (6, 7) were synthesized through a multi-step synthesis approach. All synthesized compounds were characterized using different spectroscopic tools. Previously, thiadiazole compounds as anti-Toxoplasma gondii agents have been conducted and reported in vitro. However, this is the first study to test the anti-Toxoplasma gondii activity of manufactured molecular hybrids thiadiazole in an infected mouse model with the acute RH strain of T. gondii. All the observed results demonstrated compound (7)’s powerful activity, with a considerable reduction in the parasite count reaching 82.6% in brain tissues, followed by liver and spleen tissues (65.35 and 64.81%, respectively). Inflammatory and anti-inflammatory cytokines assessments proved that Compound 7 possesses potent antiparasitic effect. Furthermore, docking tests against TgCDPK1 and ROP18 kinase (two major enzymes involved in parasite invasion and egression) demonstrated compound 7’s higher potency compared to compound 6 and megazol. According to the mentioned results, tris-1,3,4-thiadiazole derivatives under test can be employed as potent antiparasitic agents against the acute RH strain of T. gondii. 相似文献
14.
Sara M. Mostafa Ashraf A. Aly Alaa A. Hassan Esraa M. Osman Stefan Brse Martin Nieger Mahmoud A. A. Ibrahim Asmaa H. Mohamed 《Molecules (Basel, Switzerland)》2022,27(7)
An efficient synthesis of a series of pyridazino[4,3-c:5,6-c′]diquinolines was achieved via the autoxidation of 4-hydrazinylquinolin-2(1H)-ones. IR, NMR (1H and 13C), mass spectral data, and elemental analysis were used to fit and elucidate the structures of the newly synthesized compounds. X-ray structure analysis and theoretical calculations unequivocally proved the formation of the structure. The possible mechanism for the reaction is also discussed. 相似文献
15.
Kamal Tahseen Khan Sher Bahadar Bakhsh Esraa M. Anwar Yasir 《Cellulose (London, England)》2021,28(17):11067-11080
Cellulose - In this research work, we present a synthesis of silver and cobalt bimetal nanoparticles stabilized by a carboxymethyl cellulose biopolymer (CMC-AgCo) and its coating on a cellulose... 相似文献