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991.
992.
Marianna Rossetti Simone Brannetti Marco Mocenigo Bruna Marini Rudy Ippodrino Alessandro Porchetta 《Angewandte Chemie (International ed. in English)》2020,59(35):14973-14978
Easy‐to‐use platforms for rapid antibody detection are likely to improve molecular diagnostics and immunotherapy monitoring. However, current technologies require multi‐step, time‐consuming procedures that limit their applicability in these fields. Herein, we demonstrate effective molarity‐driven electrochemical DNA‐based detection of target antibodies. We show a highly selective, signal‐on DNA‐based sensor that takes advantage of antibody‐binding‐induced increase of local concentration to detect clinically relevant antibodies in blood serum. The sensing platform is modular, rapid, and versatile and allows the detection of both IgG and IgE antibodies. We also demonstrate the possible use of this strategy for the monitoring of therapeutic monoclonal antibodies in body fluids. Our approach highlights the potential of harnessing effective molarity for the design of electrochemical sensing strategies. 相似文献
993.
Galina F. Makhaeva Nadezhda V. Kovaleva Elena V. Rudakova Natalia P. Boltneva Sofya V. Lushchekina Irina I. Faingold Darya A. Poletaeva Yuliya V. Soldatova Raisa A. Kotelnikova Igor V. Serkov Anatoly K. Ustinov Alexey N. Proshin Eugene V. Radchenko Vladimir A. Palyulin Rudy J. Richardson 《Molecules (Basel, Switzerland)》2020,25(24)
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. All compounds were potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with selectivity toward BChE. Lead compound 8c, 2,6-di-tert-butyl-4-{[2-(7,8,9,10- tetrahydro-6H-cyclohepta[b]quinolin-11-ylamino)-ethylimino]-methyl}-phenol exhibited an IC50(AChE) = 1.90 ± 0.16 µM, IC50(BChE) = 0.084 ± 0.008 µM, and 13.6 ± 1.2% propidium displacement at 20 μM. Compounds possessed low activity against carboxylesterase, indicating likely absence of clinically unwanted drug-drug interactions. Kinetics were consistent with mixed-type reversible inhibition of both cholinesterases. Docking indicated binding to catalytic and peripheral AChE sites; peripheral site binding along with propidium displacement suggest the potential of the hybrids to block AChE-induced β-amyloid aggregation, a disease-modifying effect. Compounds demonstrated high antioxidant activity in ABTS and FRAP assays as well as inhibition of luminol chemiluminescence and lipid peroxidation in mouse brain homogenates. Conjugates 8 with amine-containing spacers were better antioxidants than those with enamine spacers 7. Computational ADMET profiles for all compounds predicted good blood-brain barrier distribution (permeability), good intestinal absorption, and medium cardiac toxicity risk. Overall, based on their favorable pharmacological and ADMET profiles, conjugates 8 appear promising as candidates for AD therapeutics. 相似文献
994.
Summary We consider the generating function
of the voltime of the Wiener sausageC
(t), which is the -neighbourhood of the Wiener path in the time interval [0,t]. For <0, the limiting behavior fort, up to logarithmic equivalence, had been determined in a celebrated work of Donsker and Varadhan. For >0 it had been investigated by van den Berg and Tóth, but in contrast to the case <0, there is no simple expression for the exponential rate known. We determine the asymptotic behaviour of this rate for small and large . 相似文献
995.
996.
Hermann Kick Volker Tank Erwin Lindermeir 《Journal of Quantitative Spectroscopy & Radiative Transfer》2005,92(4):447-455
The impact of changes of the spectral radiance in a Fourier transform spectrometer's field of view (FOV) during recording time of an interferogram is examined. Particularly systematic changes, with a time constant which is in the order of the time required to record one interferogram, are of interest here. Both an analytic and a simulative approach is made to examine the impact on the measured spectrum. Airborne measurements of fire scenes are a typical example where changes of spectral radiance during data acquisition time are inevitable. In such cases, flight velocity causes the scene in the spectrometer's FOV to change continuously, and the scene elements (fire, for example) might be expected to be dynamical even by themselves. 相似文献
997.
Murali Pendela Jos Hoogmartens Ann Van Schepdael Erwin Adams 《Rapid communications in mass spectrometry : RCM》2009,23(12):1856-1862
Dihydrostreptomycin sulphate (DHS) is a water‐soluble, broad‐spectrum aminoglycoside antibiotic. For quantitative analysis, the European Pharmacopoeia (Ph. Eur.) prescribes an ion‐pairing liquid chromatography/ultraviolet (LC/UV) method using a C18 stationary phase. Several unknown compounds were detected in commercial samples. Hence, for characterization of these unknown peaks in a commercial DHS sample, the Ph. Eur. method was coupled to mass spectrometry (MS). However, since the Ph. Eur. method uses a non‐volatile mobile phase, each peak eluted was collected and desalted before introduction into the mass spectrometer. The desalting procedure was applied to remove the non volatile salt, buffer and ion‐pairing reagent in the collected fraction. In total, 20 impurities were studied and 14 of them were newly characterized. Five impurities which are already reported in the literature were also traced in this LC/UV method. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
998.
Ohne Zusammenfassung 相似文献
999.
1000.
Sahli H. Bechhold E. Salkowski Jos Bilinski B. Wagner H. Citron Rudolf Adler Oscar Adler Ad. Jolles C. Neuberg Wilh Neimann B. Tollens V. Frommer Lindemann Ludw E. Nicolas A. Gürber Martin Krüger Jul Schmidt Fr. W. Schildbach Alex Raphael E. Abderhalden Fr. Pregl Paul Ehrlich O. Neubauer Rich Bauer Erwin Rohde und E. Voisenet 《Fresenius' Journal of Analytical Chemistry》1906,45(5-6):397-404
Ohne Zusammenfassung 相似文献