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41.
Dr. Pushpak Mizar Alessandra Burrelli Erika Günther Martin Söftje Prof. Dr. Umar Farooq Prof. Dr. Thomas Wirth 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(41):13113-13116
A new chiral thiohydantoin catalyst is used for the stereoselective iodoamination of alkenes. N‐iodosuccinimide as the source of the electrophilic iodine is activated by catalytic amounts of different additives which also influence the regioselectivity of some cyclizations. 相似文献
42.
Kunihiro Ichimura Masatoshi Kidowaki Haruhisa Akiyama Kazuaki Kudo Veronika Strehmel Bernd Strehmel 《Macromolecular rapid communications》1996,17(8):545-551
The surface-assisted alignment of a nematic liquid crystal yields a persistent ordered structure upon cationic photopolymerization of liquid-crystalline epoxides. Linearly polarized light irradiation of a photocrosslinkable polymer containing azobenzene moieties played a crucial role in this procedure since the photoinduced alignment is not deteriorated by heating for polymerization. 相似文献
43.
Diana Trujillo-Benítez Myrna Luna-Gutirrez Guillermina Ferro-Flores Blanca Ocampo-García Clara Santos-Cuevas Gerardo Bravo-Villegas Enrique Morales-vila Pedro Cruz-Nova Lorenza Díaz-Nieto Janice García-Quiroz Erika Azorín-Vega Antonio Rosato Laura Melndez-Alafort 《Molecules (Basel, Switzerland)》2022,27(1)
Fibroblast activation protein (FAP) is expressed in the microenvironment of most human epithelial tumors. 68Ga-labeled FAP inhibitors based on the cyanopyrrolidine structure (FAPI) are currently used for the detection of the tumor microenvironment by PET imaging. This research aimed to design, synthesize and preclinically evaluate a new FAP inhibitor radiopharmaceutical based on the 99mTc-((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl) pyrrolidin-2-yl) boronic acid (99mTc-iFAP) structure for SPECT imaging. Molecular docking for affinity calculations was performed using the AutoDock software. The chemical synthesis was based on a series of coupling reactions of 6-hidrazinylnicotinic acid (HYNIC) and D-alanine to a boronic acid derivative. The iFAP was prepared as a lyophilized formulation based on EDDA/SnCl2 for labeling with 99mTc. The radiochemical purity (R.P.) was verified via ITLC-SG and reversed-phase radio-HPLC. The stability in human serum was evaluated by size-exclusion HPLC. In vitro cell uptake was assessed using N30 stromal endometrial cells (FAP positive) and human fibroblasts (FAP negative). Biodistribution and tumor uptake were determined in Hep-G2 tumor-bearing nude mice, from which images were acquired using a micro-SPECT/CT. The iFAP ligand (Ki = 0.536 nm, AutoDock affinity), characterized by UV-Vis, FT-IR, 1H–NMR and UPLC-mass spectroscopies, was synthesized with a chemical purity of 92%. The 99mTc-iFAP was obtained with a R.P. >98%. In vitro and in vivo studies indicated high radiotracer stability in human serum (>95% at 24 h), specific recognition for FAP, high tumor uptake (7.05 ± 1.13% ID/g at 30 min) and fast kidney elimination. The results found in this research justify additional dosimetric and clinical studies to establish the sensitivity and specificity of the 99mTc-iFAP. 相似文献
44.
Proteome analysis of Oncorhynchus species during embryogenesis 总被引:3,自引:0,他引:3
Kanaya S Ujiie Y Hasegawa K Sato T Imada H Kinouchi M Kudo Y Ogata T Ohya H Kamada H Itamoto K Katsura K 《Electrophoresis》2000,21(9):1907-1913
To understand the molecular mechanisms underlying normal and abnormal development of two salmonids, masu salmon (Oncorhynchus masou) and rainbow trout (O. mykiss), we used two-dimensional (2-D) electrophoresis to construct a series of 2-D maps during the embryonic period. We identified all visible protein spots on the 2-D map by assigning numbers for masu salmon and rainbow trout, and we determined N-terminal sequences of proteins for one hundred of the spots, that appear at very high concentrations in the whole embryos of masu salmon and rainbow trout. We also characterized embryonic stages according to the periods of appearance of spots. Most of the N-terminal sequences were identical or at least highly similar to partial sequences reported for vitellogenin (Vtg) of O. mykiss. A potential proteolytic processing of Vtg for rainbow trout is discussed in relation to the time of appearance and relative position of Vtg fragments within the complete protein sequence. 相似文献
45.
Erika S. Eichmann Jennifer S. Brodbelt 《Journal of the American Society for Mass Spectrometry》1993,4(3):230-241
The reactions of dimethyl ether ions with neutral amino alcohols were examined in both a quadrupole ion trap mass spectrometer and a triple quadrupole mass spectrometer. These ion-molecule reactions produced two types of ions: the protonated species [M+l]+ and a more complex product at [M+13]+. The abundance of the [M+13]+ ions relative to that of the [M+1]+ ions decreases with increasing formal interfunctional distance. Multistage collision-activated dissociation techniques were used to characterize the [M+13]+ product ions, their reactivities, and the mechanisms for their formation and dissociation. In addition, molecular semiempirical calculation methods were used to probe the thermochemistry of these reactions. Reaction at the amino alcohol nitrogen site is favored, and the resulting [M+13]+ addition products may cyclize for additional stabilization. Comparisons were made among the behavior of related compounds, such as alcohols, diols, amines, and diamines. The alcohols reacted only to form the protonated species, but the diols, amines, and diamines all formed significant amounts of [M+13]+ ions or related dissociation products. 相似文献
46.
We consider the problem of discriminating between states of a specified set with maximum confidence. For a set of linearly independent states unambiguous discrimination is possible if we allow for the possibility of an inconclusive result. For linearly dependent sets an analogous measurement is one which allows us to be as confident as possible that when a given state is identified on the basis of the measurement result, it is indeed the correct state. 相似文献
47.
Noralvis Fleitas-Salazar Erika Silva-Campa Seidy Pedroso-Santana Judith Tanori Martín R. Pedroza-Montero Raúl Riera 《Journal of nanoparticle research》2017,19(3):113
Polyethylene glycol (PEG) molecules act as a reducing and stabilizing agent in the formation of silver nanoparticles. PEG undergoes thermal oxidative degradation at temperatures over 70 °C in the presence of oxygen. Here, we studied how the temperature and an oxidizing atmosphere could affect the synthesis of silver nanoparticles with PEG. We tested different AgNO3 concentrations for nanoparticles syntheses using PEG of low molecular weight, at 60 and 100 °C. At the higher temperature, the reducing action of PEG increased and the effect of PEG/Ag+ ratio on nanoparticles aggregation changed. These results suggest that different synthesis mechanisms operate at 60 and 100 °C. Thus, at 60 °C the reduction of silver ions can occur through the oxidation of the hydroxyl groups of PEG, as has been previously reported. We propose that the thermal oxidative degradation of PEG at 100 °C increases the number of both, functional groups and molecules that can reduce silver ions and stabilize silver nanoparticles. This degradation process could explain the enhancement of PEG reducing action observed by other authors when they increase the reaction temperature or use a PEG of higher molecular weight 相似文献
48.
Minamisono T. Matsuta K. Minamisono K. Kudo S. Ogura M. Fukuda S. Sato K. Mihara M. Fukuda M. 《Hyperfine Interactions》2001,136(3-8):225-231
In order to precisely determine the |eqQ(41Sc)/h| of 41Sc(I
π=7/2−, T
1/2=0.596 s) implanted in a TiO2 single crystal the electric field gradient tensor and anisotropic chemical shift were determined by detecting the Fourier
Transformed Pulse-NMR of 45Sc(I
π=7/2−, stable) in the crystal at a high field of 7.0 T and 9.4 T. Combining the new |eqQ(41Sc)/h| value with the Q(45Sc)=−(23.6±0.2) fm2, also renewed by using the known atomic hyperfine interaction constants and Sternheimer polarization effect, the |Q(41Sc;I
π=7/2−,T
1/2=0.596 s)|=(15.6±0.3) fm2 has been precisely determined. The value is compared with the theoretical Q(41Sc) given by a shell model code.
This revised version was published online in September 2006 with corrections to the Cover Date. 相似文献
49.
Dr. Noemi Linares Dr. Erika De Oliveira Jardim Dr. Geetu Sharma Dr. Elena Serrano Prof. Alexandra Navrotsky Prof. Dr. Javier García-Martínez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(43):10045-10048
With the aim of understanding the thermochemistry of the introduction of mesoporosity in zeolites by using surfactants, high temperature oxide melt solution calorimetry was used to determine the change in the enthalpy of formation of USY zeolite before and after the introduction of mesoporosity. Our results confirm that this process only slightly destabilizes the zeolite by the additional surface area. However, this can be overcome by the stabilizing effect of the interactions between the surfactant and the zeolite framework. 相似文献
50.
Elisa Musella Dr. Isacco Gualandi Dr. Erika Scavetta Dr. Massimo Gazzano Arianna Rivalta Dr. Elisabetta Venuti Dr. Meganne Christian Dr. Vittorio Morandi Prof. Dr. Domenica Tonelli 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(71):16301-16310
Layered double hydroxides (LDHs) have been widely studied for their plethora of fascinating features and applications. The potentiostatic electrodeposition of LDHs has been extensively applied in the literature as a fast and direct method to substitute classical chemical routes. However, the electrochemical approach does not usually allow for a fine control of the MII/MIII ratio in the synthesized material. By employing a recently proposed potentiodynamic method, LDH films of controlled composition are herein prepared with good reproducibility, using different ratios of the trivalent (Fe or Al) to bivalent (Co) cations in the electrolytic solution. All the obtained materials are shown to be effective oxygen evolution reaction (OER) catalysts, and are thoroughly characterized by a multi-technique approach, including FE-SEM, XRD, Raman, AES and a wide range of electrochemical procedures. 相似文献