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941.
Arijit Das Eric Soehnlen Stephan Woods Ravi Hegde Amanda Henry Arne Gericke Soumitra Basu 《Journal of nanoparticle research》2011,13(12):6283-6290
We report a novel gold nanobioconjugate system that achieves targeted delivery of the small molecule drug doxorubicin to endothelial
cells using anti-VEGFR-2 antibody conjugated gold nanoparticles (GNPs). The reported nanobioconjugate system combines the
inherent ability of GNPs to undergo high levels of derivatization with the precision of antibody recognition of a cell surface
antigen. Transmission electron microscopy (TEM) and surface-enhanced Raman spectroscopy (SERS) confirmed intracellular presence
of the GNPs. Using a VEGFR-2 expressing cell line and a cell line that is negative for the receptor, in combination with competition
assay we established the cell specific targeted delivery of the nanobioconjugate. The nanobioconjugate system described here
may have potential drug delivery applications for antiangiogenic cancer therapy. 相似文献
942.
Margriet V. D. Z. Park Iseult Lynch Sonia Ram��rez-Garc��a Kenneth A. Dawson Liset de la Fonteyne Eric Gremmer Wout Slob Jacob J. Bried�� Andreas Elsaesser C. Vyvyan Howard Henk van Loveren Wim H. de Jong 《Journal of nanoparticle research》2011,13(12):6775-6787
The biological response to four well-characterized amorphous silica nanoparticles was investigated in RAW 264.7 macrophages in view of their potential application as drug carriers to sites of inflammation. All silica nanoparticles-induced cell membrane damage, reduced metabolic activity, generated ROS and released various cytokines, but to different extents. Two silica nanoparticles of 34 nm (A and B) with different zetapotentials were more cytotoxic than (aggregated) 11 and 248 nm nanoparticles, while cytokines were mostly induced by the (aggregated) 11 nm and only one of the 34 nm nanoparticles (34A). The results indicate that specific silica nanoparticles may have counterproductive effects, for example when used as carriers of anti-inflammatory drugs. The physicochemical properties determining the response of nanoparticles vary for different responses, implying that a screening approach for the safe development of nanoparticles needs to consider the role of combinations of (dynamic) physicochemical properties and needs to include multiple toxicity endpoints. 相似文献
943.
Lauga E 《Physical review letters》2011,106(17):178101
Purcell's scallop theorem states that swimmers deforming their shapes in a time-reversible manner ("reciprocal" motion) cannot swim. Using numerical simulations and theoretical calculations we show here that, in a fluctuating environment, reciprocal swimmers undergo, on time scales larger than that of their rotational diffusion, diffusive dynamics with enhanced diffusivities, possibly by orders of magnitude, above normal translational diffusion. Reciprocal actuation does therefore lead to a significant advantage over nonmotile behavior for small organisms such as marine bacteria. 相似文献
944.
The extended boundary condition method, also called the null-field method, provides a semianalytic solution to the problem of electromagnetic scattering by a particle by constructing a transition matrix (T-matrix) that links the scattered field to the incident field. This approach requires the computation of specific integrals over the particle surface, which are typically evaluated numerically. We introduce here a new set of simplified expressions for these integrals in the commonly studied case of axisymmetric particles. Simplifications are obtained using the differentiation properties of the radial functions (spherical Bessel) and angular functions (associated Legendre functions) and integrations by parts. The resulting simplified expressions not only lead to faster computations, but also reduce the risks of loss of precision and provide a simpler framework for further analytical work. 相似文献
945.
Guided mode resonance (GMR) filters are highly functional micro-optics capable of narrowband spectral filtering. GMR devices have previously been demonstrated on flat substrates using a wide range of materials and configurations. In this Letter, we apply a soft lithographic technique followed by the deposition of dielectric layers to generate GMR filters on a concave lens surface. Resonances of the resulting conformal GMR filters are experimentally measured and characterized, and the results are compared to the performance of similar GMR filters fabricated on flat surfaces. 相似文献
946.
Temporal cleaning of a high-energy fiber-based ultrafast laser using cross-polarized wave generation
Zaouter Y Ramirez LP Papadopoulos DN Hönninger C Hanna M Druon F Mottay E Georges P 《Optics letters》2011,36(10):1830-1832
We report the use of cross-polarized wave generation to perform both pulse shortening and temporal cleaning of a high-energy ytterbium-doped fiber-based femtosecond laser system. The nonlinear processes allow both a highly efficient nonlinear conversion of 20% and a large compression ratio of 3.5, with inherently improved coherent and incoherent contrasts. This results in the generation of 37 μJ, 115 fs pulses at a repetition rate of 100 kHz with high temporal quality. 相似文献
947.
Matthew J. Smith Mark Winkler Meng-Ju Sher Yu-Ting Lin Eric Mazur Silvija Gradečak 《Applied Physics A: Materials Science & Processing》2011,105(4):795-800
Femtosecond (fs) laser irradiation of a silicon substrate coated with a thin film is a flexible approach to producing metastable
alloys with unique properties, including near-unity sub-band gap absorptance extending into the infrared. However, dopant
incorporation from a thin film during fs-laser irradiation is not well understood. We study the thin film femtosecond-laser
doping process through optical and structural characterization of silicon fs-laser doped using a selenium thin film, and compare
the resulting microstructure and dopant distribution to fs-laser doping with sulfur from a gaseous precursor. We show that
a thin film dopant precursor significantly changes the laser-material interactions, modifying both the surface structuring
and dopant incorporation processes and in turn affecting p–n diode behavior. 相似文献
948.
Carlos Montoya Odile Bellenguez-Morineau Eric Pinson David Rivreau 《Optimization Letters》2014,8(5):1721-1734
This work introduces a procedure to solve the multi-skill project scheduling problem (MSPSP) (Néron and Baptista, International symposium on combinatorial, optimization (CO’2002), 2002). The MSPSP mixes both the classical resource constrained project scheduling problem and the multi-purpose machine model. The aim is to find a schedule that minimizes the completion time (makespan) of a project, composed of a set of activities. In addition, precedence relations and resources constraints are considered. In this problem, resources are staff members that master several skills. Thus, a given number of workers must be assigned to perform each skill required by an activity. Practical applications include the construction of buildings, as well as production and software development planning. We present a column generation approach embedded within a branch-and-price (B&P) procedure that considers a given activity and time-based decomposition approach. Obtained results show that the proposed B&P procedure is able to reach optimal solutions for several small and medium sized instances in an acceptable computational time. Furthermore, some previously open instances were optimally solved. 相似文献
949.
Let F be a field finitely generated and of transcendence degree one over a p-adic field, and let ? ≠ p be a prime. Results of Merkurjev and Saltman show that H2(F, µ?) is generated by ?/?-cyclic classes. We prove the “?/?-length” in H2(F, µ?) is less than the ?-Brauer dimension, which Salt-man showed to be three. It follows that all F-division algebras of period ? are crossed products, either cyclic (by Saltman’s cyclicity result) or tensor products of two cyclic F-division algebras. Our result was originally proved by Suresh when F contains the ?-th roots of unity µ?. 相似文献
950.
Eric C. Chi Liuyi Hu Arvind K. Saibaba Arvind U. K. Rao 《Journal of computational and graphical statistics》2019,28(1):36-47
We consider the problem of performing matrix completion with side information on row-by-row and column-by-column similarities. We build upon recent proposals for matrix estimation with smoothness constraints with respect to row and column graphs. We present a novel iterative procedure for directly minimizing an information criterion to select an appropriate amount of row and column smoothing, namely, to perform model selection. We also discuss how to exploit the special structure of the problem to scale up the estimation and model selection procedure via the Hutchinson estimator, combined with a stochastic Quasi-Newton approach. Supplementary material for this article is available online. 相似文献