Quantitative determination of 43 common drugs and drugs of abuse in human serum by HPLC-MS/MS

An analytical procedure for the simultaneous determination in human serum of 43 common drugs of abuse and their metabolites belonging to the different chemical and toxicological classes of amphetamines, benzodiazepines, dibenzazepines, cocaine, lysergic acid diethylamide, opioids, phencyclidine, tricyclic antidepressants, and zolpidem, using 33 deuterated standards, is presented. The sample treatment was developed to be a very simple protein precipitation and filtration. All analyses were performed with a high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in positive ionization mode. All analytes were calibrated up to 550 μg/L. The limit of detection ranged from 0.6 ng/mL (EDDP) to 13.7 ng/mL (flunitrazepam). The method has been validated according to the guidelines of the Gesellschaft für Toxikologische und Forensische Chemie, using three multiple reaction mode (MRM) transitions and retention time for positive compound identification, instead of two MRMs, in anticipation of the new guidelines for January 2011.     

Postbuckling of imperfect rectangular composite plates under inplane shear closed-form approximate solutions

In this paper, the postbuckling behavior of rectangular orthotropic laminated composite plates with initial imperfections under inplane shear load is investigated in a closed-form analytical manner. The plates under consideration are assumed to be infinitely long in the longitudinal direction. At the longitudinal edges, two different sets of boundary conditions are considered, specifically 1) simply supported edges and 2) fully clamped edges. Using Timoshenko-type shape functions for both the initial bifurcational buckling analysis and the subsequent Marguerre-type postbuckling studies, closed-form analytical solutions for the buckling loads and for the postbuckling state variables are derived. A comparison with geometrically non-linear finite element computations shows that the derived analysis approaches are suitable for postbuckling studies in load ranges not too far beyond bifurcational buckling as they are currently relevant for e.g., composite airframe structural analysis and design. Due to their strictly closed-form analytical nature, the presented analysis methods can be used conveniently in engineering practice for all application purposes where computational time is a crucial factor, especially for preliminary analysis and design or optimization procedures.     

An Approximate Distribution for the Maximum Order Complexity

In this paper we give an approximate probability distribution for the maximum order complexity of a random binary sequence. This enables the development of statistical tests based on maximum order complexity for the testing of a binary sequence generator. These tests are analogous to those based on linear complexity.     

Nachweis der salpetrigen S?ure im Trinkwasser

Ohne Zusammenfassung     

Structural studies of poly(paraphenylene), poly(2,5-thienylene) and their derivatives by solid-state NMR of 1H and 13C

Transient techniques in NMR of ¹H and ¹³C were used to study the chemical and physical structures of solid poly(p-phenylene) (PPP), poly(2,6-dimethyl-p-phenylene oxide) (PDMPO), poly(p-phenylene sulfide) (PPS), poly(p-biphenylene sulfide) (PPBS), poly(p-phenylene selenide) (PPSe), poly(p-biphenylene selenide) (PPBSe), poly(2,5-thienylene) (PT), poly(3-methyl-2,5-thienylene) (PMT), and poly(p-phenylene-co-2,5-thienlyene) (PPPT) of different monomer ratios. ¹³C NMR confirmed the expected chemical structure for homopolymers, and indicated a random distribution of monomer units in PPPT. Relative fractions of crystalline and interfacial regions were determined by measurements of ¹H magnetic relaxation, ¹³C CP/MAS NMR, and XRD. © 1994 John Wiley & Sons, Inc.