Chemometric determination of naproxen sodium and pseudoephedrine hydrochloride in tablets by HPLC

A new chemometric determination by high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was implemented for the simultaneous determination of naproxen sodium and pseudoephedrine hydrochloride in tablets. Three chemometric calibration techniques, classical least squares (CLS), principle component regression (PCR) and partial least squares (PLS) were applied to the peak area at multiwavelength PDA detector responses. The combinations of HPLC with chemometric calibration techniques were called HPLC-CLS, HPLC-PCR and HPLC-PLS. For comparison purposes the HPLC method called the classic HPLC method was used to confirm the results obtained from combined HPLC-chemometric calibration techniques. A good chromatographic separation between two drugs with losartan potassium as an internal standard was achieved using a Waters Symmetry C18 Column 5 microm 4.6+/-250 mm and a mobile phase containing 0.2 M acetate buffer and acetonitrile (v/v, 40:60). The multiwavelength PDA detection was measured at five different wavelengths. The chromatograms were recorded as a training set in the mobile phase. Three HPLC-chemometric calibrations and the classic-HPLC method were used to test the synthetic mixtures of naproxen sodium and pseudoephedrine hydrochloride in the presence of the internal standard. The HPLC-chemometric approaches were applied to real samples containing drugs of interest. The experimental results obtained from HPLC-chemometric calibrations were compared with those obtained by a classic HPLC method.     

Coupled coincidence point results on generalized distance in ordered cone metric spaces

In this paper, we establish some coupled coincidence point results in the setting of partially ordered cone metric spaces via $c$ -distance. We also proved some related coupled common fixed point theorems for such mappings. Our results generalize, extend, and unify several well-known comparable results in the literature regarding this topic. We present some examples to illustrate the concepts and results.     

Relations between simplicial groups, 3-crossed modules and 2-quadratic modules

In this paper, we define two-quadratic module and explore the relations among two-quadratic modules, three-crossed modules and simplicial groups.     

β−type fractional Sturm‐Liouville Coulomb operator and applied results

In this article, β‐type fractional Sturm‐Liouville Coulomb operator is considered by Hilfer fractional derivative. Fundamental spectral theory is investigated for the aforementioned problem. In this context, it is shown that the operator is self‐adjoint, eigenfunctions correspond to the distinct eigenfunctions are orthogonal, and eigenvalues are real. Furthermore, applications of this problem are given by the Adomian decomposition method and the results are shown with visual graphs.     

Coordination of staffing and pricing decisions in a service firm

Customer demand is sensitive to the price paid for the service in many service environments. Using queueing theory framework, we develop profit maximization models for jointly determining the price and the staffing level in a service company. The models include constraints on the average waiting time and the blocking probability. We show convexity of the single‐variable subproblem under certain plausible assumptions on the demand and staffing cost functions. Using numerical examples, we investigate the sensitivity of the price and the staffing level to changes in the marginal service cost and the user‐specified constraint on the congestion measure. Copyright © 2008 John Wiley & Sons, Ltd.     

A new application of continuous wavelet transform to overlapping chromatograms for the quantitative analysis of amiloride hydrochloride and hydrochlorothiazide in tablets by ultra-performance liquid chromatography

A new application of continuous wavelet transform (CWT) to overlapping peaks in a chromatogram was developed for the quantitative analysis of amiloride hydrochloride (AML) and hydrochlorothiazide (HCT) in tablets. Chromatographic analysis was done by using an ACQUITY ultra-performance LC (UPLC) BEH C18 column (50 x 2.1 mm id, 1.7 pm particle size) and a mobile phase consisting of methanol-0.1 M acetic acid (21 + 79, v/v) at a constant flow rate of 0.3 mL/min with diode array detection at 274 nm. The overlapping chromatographic peaks of the calibration set consisting of AML and HCT mixtures were recorded rapidly by using an ACQUITY UPLC H-Class system. The overlapping UPLC data vectors of AML and HCT drugs and their samples were processed by CWT signal processing methods. The calibration graphs for AML and HCT were computed from the relationship between concentration and areas of chromatographic CWT peaks. The applicability and validity of the improved UPLC-CWT approaches were confirmed by recovery studies and the standard addition technique. The proposed UPLC-CWT methods were applied to the determination of AML and HCT in tablets. The experimental results indicated that the suggested UPLC-CWT signal processing provides accurate and precise results for industrial QC and quantitative evaluation of AML-HCT tablets.     

Iterative joint data detection and channel estimation for uplink MC-CDMA systems in the presence of frequency selective channels

This paper is concerned with joint multiuser detection and multichannel estimation (JDE) for uplink multicarrier code-division multiple-access (MC-CDMA) systems in the presence of frequency selective channels. The detection and estimation, implemented at the receiver, are based on a version of the expectation maximization (EM) algorithm and the space-alternating generalized expectation–maximization (SAGE) which are very suitable for multicarrier signal formats. The EM-JDE receiver updates the data bit sequences in parallel, while the SAGE-JDE receiver reestimates them successively. The channel parameters are updated in parallel in both schemes. Application of the EM-based algorithm to the problem of iterative data detection and channel estimation leads to a receiver structure that also incorporates a partial interference cancelation. Computer simulations show that the proposed algorithms have excellent BER end estimation performance.     

Generalization of perfectly continuous,regular set-connected and clopen functions

Summary Noiri in 1984, Dontchev, Ganster and Reilly in recent years and Reilly and Vamanamurthy in 1983 introduced the notion of perfectly continuous, regular set-connected and clopen functions, respectively. The aim of this paper is to introduce the notion of a new class of functions which is called almost clopen functions including the classes of perfectly continuous, regular set-connected and clopen functions. Furthermore, properties of almost clopen functions are obtained and relationships among almost clopenness, perfect continuity, regular set-connectedness, clopenness and almost continuity are investigated.     

Mechanical, thermal, and fire retardant properties of poly(ethylene terephthalate) fiber containing zinc phosphinate and organo-modified clay

The effect of zinc bisdiethylphosphinate (ZnPi) and organoclay on mechanical, thermal, and flame retardant properties of poly(ethylene terephthalate) (PET) fiber was investigated. ZnPi was preferred due to its fusible character at spinning temperature and organoclay was used for synergistic interaction. The mechanical, thermal, and flame retardant properties of fibers were examined by tensile testing, thermogravimetric analysis (TG), and micro combustion calorimeter (MCC). The tensile strength of the PET fiber reduced with the addition of both ZnPi and organoclay. The TG results showed that the inclusion of ZnPi increased the char residue. The MCC results showed that the addition of organoclay increased the barrier effect of formed char which depends on char amount, thickness, and integrity and reduces the maximum heat evolved during the test. This result was also important in terms of showing that the organoclay was effective in thermally thin samples.