XI. The Borel transform and the renormalization group

We study the consequences of the renormalization group on the large momenta behaviour of the Borel transform of the Green's functions. We discuss the implications on the structure of the ultraviolet singularities of the Borel transform.     

Gluon fragmentation functions from quark jets

The analysis of events with a fixed, different from unity, fraction of energy flowing into a solid angle ΔΩ can be used to extract the probability functions related to the scaling violations of deep inelastic scattering. One can obtain from the study of a quark jet, both the gluon and the quark fragmentation functions into hadrons.     

Asymptotic predictions for exclusive processes

It is argued that in QCD it is possible to compute the asymptotic behaviour of exclusive processes such as form factors, threshold behaviour of structure functions, production of low-mass jets, elastic scattering, … . Only a few phenomenological parameters are needed as an input.     

Complex singularities in the specific heat of the SU(2) lattice gauge model

A recent Monte Carlo simulation showing a sharp peak versus β in the specific heat for an SU(2) lattice gauge theory is compared with the high temperature expansion. An interpretation based on complex β-plane singularities is proposed.     

Molecularly imprinted hydrogels for sustained release of sunitinib in breast cancer therapy

The present work reports on the synthesis of a molecularly imprinted polymer (MIP) based on methacrylic acid and ethylene glycol dimethacrylate for sunitinib delivery. Sunitinib (SUT) is a tyrosine kinase inhibitor used in many cancer diseases. Like the majority of the anticancer drugs, SUT suffers of a low bioavailability, and at the same time, it is characterized by a narrow therapeutic window. In order to reduce drug systemic toxicity, we synthesized a MIP‐based drug delivery system for SUT‐controlled release. MIP was obtained by bulk polymerization through the so‐called noncovalent approach. Rebinding experiments were performed to evaluate the success of the imprinting process and the ability of MIP to bind in a specific and selective fashion the template molecule. Resulting data showed that sunitinib rebinding percentage was 70%, while nonimprinted polymer (NIP) rebinding percentage was 46%. A not significant difference was observed between MIP and NIP in semaxanib binding experiments. Moreover, the drug release profiles were studied for both MIP and NIP. A sustained release was observed from sunitinib‐loaded MIP during 24 hours, reaching 58% after 6 hours and 76% at the end‐point. NIP, on the contrary, released almost 90% of the loaded drug within 6 hours. Furthermore, the drug carrier was tested in vitro against MCF‐7 cells, in which the cytotoxic effect of sunitinib released from MIP reached the maximum after 72 hours, while NIP completed its effect within 48 hours. These results demonstrated that molecularly imprinted polymers are suitable systems for SUT release.     

Phase transitions of bipartite entanglement

We analyze the statistical properties of the entanglement of a large bipartite quantum system. By framing the problem in terms of random matrices and a fictitious temperature, we unveil the existence of two phase transitions, characterized by different spectra of the reduced density matrices.     

Diode-pumped single-frequency Tm:LiLuF(4) ring laser

We report a room-temperature single-frequency Tm:LiLuF(4) laser with a maximum output power of 120 mW, a slope efficiency of 13%, and a wavelength tunability range from 1875 to 1895 nm. Both frequency and relative intensity noise have been investigated, showing an emission linewidth of ~300 kHz over 1 ms observation time and an intensity noise spectrum limited by quantum noise for Fourier frequencies larger than 5 MHz.     

Serum protein profiling in patients with inflammatory bowel diseases using selective solid-phase bulk extraction, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemometric data analysis

The identification of new biomarkers or a disease-related protein fingerprint for inflammatory bowel diseases (IBDs) represents a major task in the diagnosis, prognosis and pharmacological therapy. To address these issues, a simple and rapid analytical proteomic method for serum protein profiling based on selective beads-based solid-phase bulk extraction, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and chemometric data analysis was developed. Serum proteins from healthy subjects (22) and patients with Crohn's disease (15) and ulcerative colitis (26) were selectively extracted according to reversed-phase (C18), strong anion-exchange (SAX) and metal ion affinity (IDA-Cu(II)) principles. This approach allowed enrichment of serum proteins/peptides due to the high interaction surface between analytes and the solid phase and high recovery due to the elution step performed directly on the MALDI-target plate. The MALDI-TOF MS serum protein profiles were acquired and, after a data pre-processing step, analyzed by linear discriminant analysis (LDA), a chemometric classification technique, in order to classify serum samples among healthy subjects and patients with inflammatory bowel diseases (IBDs). Since the high number of variables in the MALDI spectra (more than 16000 m/z values) prevents the use of LDA, the variables were reduced to 10-20 by features selection, thus allowing the evaluation of a pattern of m/z values with high discriminant power. Serum protein profiles obtained by reversed-phase extraction and the selection of 20 m/z values gave the best overall prediction ability (96.9%). The recognition of these m/z values may allow the identification of protein biomarkers involved in IBDs.