全文获取类型
收费全文 | 1136篇 |
免费 | 55篇 |
国内免费 | 4篇 |
专业分类
化学 | 927篇 |
晶体学 | 6篇 |
力学 | 10篇 |
数学 | 63篇 |
物理学 | 189篇 |
出版年
2023年 | 18篇 |
2022年 | 18篇 |
2021年 | 32篇 |
2020年 | 43篇 |
2019年 | 27篇 |
2018年 | 26篇 |
2017年 | 21篇 |
2016年 | 31篇 |
2015年 | 45篇 |
2014年 | 34篇 |
2013年 | 65篇 |
2012年 | 85篇 |
2011年 | 99篇 |
2010年 | 37篇 |
2009年 | 24篇 |
2008年 | 78篇 |
2007年 | 90篇 |
2006年 | 78篇 |
2005年 | 64篇 |
2004年 | 53篇 |
2003年 | 44篇 |
2002年 | 33篇 |
2001年 | 8篇 |
2000年 | 13篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1989年 | 2篇 |
1988年 | 9篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 3篇 |
1939年 | 1篇 |
1893年 | 1篇 |
排序方式: 共有1195条查询结果,搜索用时 15 毫秒
51.
Andreas Dorian Emily J. Landgreen Hayley R. Petras Prof. James J. Shepherd Prof. Florence J. Williams 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(42):10839-10843
The facile production of ArCF2X and ArCX3 from ArCF3 using catalytic iron(III)halides is reported, which constitutes the first iron-catalyzed halogen exchange for non-aromatic C−F bonds. Theoretical calculations suggest direct activation of C−F bonds by iron coordination. ArCX3 and ArCF2X products of the reaction are synthetically valuable due to their diversification potential. In particular, chloro- and bromodifluoromethyl arenes (ArCF2Cl, ArCF2Br respectively) provide access to a myriad of difluoromethyl arene derivatives (ArCF2R). To optimize for mono-halogen exchange, a statistical method called Design of Experiments was used. Optimized parameters were successfully applied to electron rich and electron deficient aromatic substrates, and to the late stage diversification of flufenoxuron, a commercial insecticide. These methods are highly practical, being run at convenient temperatures and using inexpensive common reagents. 相似文献
52.
53.
Nandan Haloi Archit Kumar Vasan Emily J. Geddes Arjun Prasanna Po-Chao Wen William W. Metcalf Paul J. Hergenrother Emad Tajkhorshid 《Chemical science》2021,12(45):15028
Antibiotic resistance of Gram-negative bacteria is largely attributed to the low permeability of their outer membrane (OM). Recently, we disclosed the eNTRy rules, a key lesson of which is that the introduction of a primary amine enhances OM permeation in certain contexts. To understand the molecular basis for this finding, we perform an extensive set of molecular dynamics (MD) simulations and free energy calculations comparing the permeation of aminated and amine-free antibiotic derivatives through the most abundant OM porin of E. coli, OmpF. To improve sampling of conformationally flexible drugs in MD simulations, we developed a novel, Monte Carlo and graph theory based algorithm to probe more efficiently the rotational and translational degrees of freedom visited during the permeation of the antibiotic molecule through OmpF. The resulting pathways were then used for free-energy calculations, revealing a lower barrier against the permeation of the aminated compound, substantiating its greater OM permeability. Further analysis revealed that the amine facilitates permeation by enabling the antibiotic to align its dipole to the luminal electric field of the porin and form favorable electrostatic interactions with specific, highly-conserved charged residues. The importance of these interactions in permeation was further validated with experimental mutagenesis and whole cell accumulation assays. Overall, this study provides insights on the importance of the primary amine for antibiotic permeation into Gram-negative pathogens that could help the design of future antibiotics. We also offer a new computational approach for calculating free-energy of processes where relevant molecular conformations cannot be efficiently captured.A rapid pathway sampling method combining Monte Carlo and graph theory, developed to describe permeation pathways through outer membrane porins, can distinguish between structurally similar analogs with different permeabilities. 相似文献
54.
55.
56.
Proteases are key regulators of many physiological and pathological processes [1,2], and are recognized as important and tractable drug candidates. Consequently, knowledge of protease substrate recognition and specificity promotes identification of biologically relevant substrates, helps elucidating a protease's biological function, and the design of specific inhibitors. Traditional methods for establishing substrate recognition profiles involve the identification of the scissile bond within a given protein substrate by proteomic methods such as Edman degradation. Then, synthetic peptide variants of this sequence can be screened in an iterative fashion to arrive at more optimized substrates. Even though it can be fruitful, this iterative strategy is biased toward the original substrate sequence and it is also tremendously cumbersome. Furthermore, it is not amenable to high throughput analysis. In 1993, Matthew & Wells presented a method for the use of monovalent "substrate phage" libraries for discovering peptide substrates for proteases, in which more than 10(7) potential substrates can be tested concurrently [3]. A library of fusion proteins was constructed containing randomized substrate sequences placed between a binding domain and the gene III coat protein of the filamentous phage, M13, which displays the fusion protein and packages the gene coding for it inside. Each fusion protein was displayed as a single copy on filamentous phagemid particles (substrate phage). This method allows one to rapidly survey the substrate recognition and specificity of individual or closely related members of proteases. Over the past decade, substrate phage screening has shown terrific utility in rapidly determining protease specificity and characterization of substrate recognition profile of proteases. In some cases, the structural insights of the catalytic domain were obtained from comparison of substrate specificity among closely related family of proteases [4-6]. The number of proteases (from various classes) characterized by this approach testifies to its power. Since the initial development of substrate phage library, different versions of the substrate phage cloning vectors have been constructed to further improve the utility of substrate phage display. This review will provide an overview of the construction of substrate phage display libraries, screening of substrate phage libraries, examples of application, summary and future directions. 相似文献
57.
58.
Emulsion‐based coatings and adhesives are in growing demand due to an increased awareness of health and safety issues arising from solvent‐based polymer manufacturing processes. However, emulsion‐based techniques often require additional development to achieve equal or better application performance compared to solvent‐based processes. The inclusion of nanoparticles in emulsion‐based coatings and adhesives can be considered as a promising means to enhance performance. This paper reviews the current progress on the synthesis of emulsion‐based nanocomposites for coating and adhesive applications and addresses the principles and techniques for nanoparticle dispersions and their inclusion into polymer latexes. The effects of nanoparticle shape and size on the enhancement of nanocomposite properties are also highlighted. Among the reinforcing nanoparticles such as nanoclays, carbon nanotubes, and cellulose nanocrystals (CNCs), CNCs are promising due to their abundance, nontoxicity, and accessible surface hydroxyl groups, which facilitate their compatibility with polymer latexes via physical and chemical treatments. 相似文献
59.
Tryptanthrin is a natural product with numerous important pharmacological properties. Tryptanthrin and its analogs are commonly prepared by condensation of isatoic anhydride and isatin. In this Letter we investigate the formation of tryptanthrin derivatives upon Oxone-induced oxidative dimerization of indole-3-carbaldehydes. 相似文献