Intra-operative acoustic hemostasis of liver: production of a homogenate for effective treatment

Objective: We have shown that High-Intensity Focused Ultrasound (HIFU) can effectively control bleeding from injuries to solid organs such as liver, spleen, and lung. Achievement of hemostasis was augmented when a homogenate of tissue and blood was formed. The objective of this study was to investigate quantitatively the effect of homogenate production on HIFU application time for hemostasis. Possible mechanisms involved in homogenate production were also studied.Methods: Ten anesthetized rabbits had laparotomy and liver exposure. Liver incisions, 15-25 mm long and 3-4 mm deep, were made followed immediately by HIFU application. Two electrical powers of 80 and 100 W corresponding to focal acoustic intensities of 2264 and 2829 W/cm², respectively were used. Tissue and homogenate temperatures were measured. Smear and histological tissue sample analysis using light microscopy were performed.Results: In treatments with homogenate formation, hemostasis was achieved in 76 ± 1.3 s (Mean ± Standard Error Mean: SEM) at 80 W. In treatments without homogenate formation (at 80 W), hemostasis was achieved in 106 ± 0.87 s. At 100 W, hemostasis was achieved in 46 ± 0.3 s. The time required for homogenate formation, at 80 and 100 W were 60 ± 2.5 and 23 ± 0.3 s, respectively. The homogenate temperature was 83 °C (SEM 0.6 °C), and the non-homogenate tissue temperature at the treatment site was 60 °C (SEM 0.4 °C). The smear and histological analysis showed significant blood components and cellular debris in the homogenate, with some intact cells.Conclusion: The HIFU-induced homogenate of blood and tissue resulted in a statistically significant shorter HIFU application time for hemostasis. The incisions with homogenate had higher temperatures as compared to incisions without homogenate. Further studies of the correlation between homogenate formation and temperature must be done, as well as studies on the long-term effects of homogenate in achieving hemostasis.     

The Möbius Category of Some Combinatorial Inverse Semigroups

\noindent The purpose of this paper is to point out some aspects of the relationship between combinatorial inverse semigroups and their Möbius categories, and to explore combinatorial results arising from combinatorial Brandt semigroups, fundamental simple inverse -semigroups and from the free monogenic inverse semigroup.     

Interlaboratory evaluation of hydrophone sensitivity calibration from 0.1 to 2 MHz via time delay spectrometry

Knowing the low-frequency response of hydrophones, down to 100 kHz at least, is important for accurate biomedical ultrasound measurements. However, current international standards do not extend below 500 kHz. Furthermore, commercial hydrophone sources typically do not supply sensitivity data below 1-2 MHz. Therefore, to help identify and validate practical calibration methods below 2 MHz, the authors have extended their previous individual efforts in an interlaboratory evaluation of sensitivity calibration using the swept-frequency technique, time delay spectrometry (TDS). Calibrations were performed for needle and membrane PVDF hydrophones using each laboratory's TDS system. Each site employed the same purpose-built broadband source transducers, comprising both plano-concave and biconcave 1-3 piezocomposite elements 4 cm in diameter, with maximum and minimum thicknesses of approximately 1.5 and 0.1 cm. Agreement between laboratories was within the estimated measurement precision of +/-0.6 dB. The results demonstrated that a TDS system employing such transducers constitutes a viable method for hydrophone calibrations in this frequency range.     

Directionality of Gaussian Schell-model beams propagating in atmospheric turbulence

It is known that some partially coherent Gaussian Shell-model beams may generate, in free space, the same angular distribution of radiant intensity as a fully coherent laser beam. We show that this result also holds even if the beams propagate in atmospheric turbulence, irrespective of the particular model of turbulence used. The result is illustrated by an example.     

Effects of spatial coherence on near-field spectra

Expressions are derived for the spectrum of the field generated by a planar, homogeneous, secondary source of any spectral distribution and of any state of spatial coherence. It is shown that the state of coherence affects the contributions of the homogeneous as well as the evanescent waves of the emitted field. The near-field spectra are studied in detail. The analysis is illustrated by examples.     

Hemilabile ligands in organolithium chemistry: substituent effects on lithium ion chelation

The lithium diisopropylamide-mediated 1,2-elimination of 1-bromocyclooctene to provide cyclooctyne is investigated using approximately 50 potentially hemilabile polyethers and amino ethers. Rate laws for selected ligands reveal chelated monomer-based pathways. The dependence of the rates on ligand structure shows that anticipated rate accelerations based on the gem-dimethyl effect are nonexistent and that substituents generally retard the reaction. With the aid of semiempirical and DFT computational studies, the factors influencing chelation are discussed. It seems that severe buttressing within chelates of the substitutionally rich ligands precludes a net stabilization of the chelates relative to nonchelated (eta(1)-solvated) forms. One ligand-MeOCH(2)CH(2)NMe(2)-appears to promote elimination uniquely by a higher-coordinate monomer-based pathway.