An intrinsic approach to manifold constrained variational problems

Motivated by some questions in continuum mechanics and analysis in metric spaces, we give an intrinsic characterization of sequentially weak lower semicontinuous functionals defined on Sobolev maps with values into manifolds without embedding the target into Euclidean spaces.     

Dissipative Dynamic Covalent Chemistry (DDCvC) Based on the Transimination Reaction

This work reports that the composition of a dynamic library (DL) of interconverting imines can be controlled over time in a dissipative fashion by the addition of an activated carboxylic acid used as a chemical fuel. When the fuel is added to the DL, which is initially under thermodynamic equilibrium, the composition of the mixture dramatically changes and a new, dissipative (out of equilibrium) state is reached that persists until fuel exhaustion. Thus, a transient dissipative dynamic library (DDL) is generated that, eventually, reverts back to the initial DL when the fuel is consumed, closing a DL→DDL→DL cycle. The larger the amount of added fuel, the longer the time spent by the system in the DDL state. The transimination reaction is shown to be an optimal candidate for the realization of a dissipative dynamic covalent chemistry (DDCvC).     

Non Stationary Multi-Armed Bandit: Empirical Evaluation of a New Concept Drift-Aware Algorithm

The Multi-Armed Bandit (MAB) problem has been extensively studied in order to address real-world challenges related to sequential decision making. In this setting, an agent selects the best action to be performed at time-step t, based on the past rewards received by the environment. This formulation implicitly assumes that the expected payoff for each action is kept stationary by the environment through time. Nevertheless, in many real-world applications this assumption does not hold and the agent has to face a non-stationary environment, that is, with a changing reward distribution. Thus, we present a new MAB algorithm, named f-Discounted-Sliding-Window Thompson Sampling (f-dsw TS), for non-stationary environments, that is, when the data streaming is affected by concept drift. The f-dsw TS algorithm is based on Thompson Sampling (TS) and exploits a discount factor on the reward history and an arm-related sliding window to contrast concept drift in non-stationary environments. We investigate how to combine these two sources of information, namely the discount factor and the sliding window, by means of an aggregation function f(.). In particular, we proposed a pessimistic (f=min), an optimistic (f=max), as well as an averaged (f=mean) version of the f-dsw TS algorithm. A rich set of numerical experiments is performed to evaluate the f-dsw TS algorithm compared to both stationary and non-stationary state-of-the-art TS baselines. We exploited synthetic environments (both randomly-generated and controlled) to test the MAB algorithms under different types of drift, that is, sudden/abrupt, incremental, gradual and increasing/decreasing drift. Furthermore, we adapt four real-world active learning tasks to our framework—a prediction task on crimes in the city of Baltimore, a classification task on insects species, a recommendation task on local web-news, and a time-series analysis on microbial organisms in the tropical air ecosystem. The f-dsw TS approach emerges as the best performing MAB algorithm. At least one of the versions of f-dsw TS performs better than the baselines in synthetic environments, proving the robustness of f-dsw TS under different concept drift types. Moreover, the pessimistic version (f=min) results as the most effective in all real-world tasks.     

Time Programmable Locking/Unlocking of the Calix[4]arene Scaffold by Means of Chemical Fuels

In this work, we report that 2-cyano-2-phenylpropanoic acid and its p-Cl, p-CH₃ and p-OCH₃ derivatives can be used as chemical fuels to control the geometry of the calix[4]arene scaffold in its cone conformation. It is shown that, under the action of the fuel, the cone calix[4]arene platform assumes a “locked” shape with two opposite aromatic rings strongly convergent and the other two strongly divergent (“pinched cone” conformation). Only when the fuel is exhausted, the cone calix[4]arene scaffold returns to its resting, “unlocked” shape. Remarkably, the duration of the “locked” state can be controlled at will by varying the fuel structure or amount. A kinetic study of the process shows that the consume of the fuel is catalyzed by the “unlocked” calixarene that behaves as an autocatalyst for its own production. A mechanism is proposed for the reaction of fuel consumption.     

Functional MRI changes in the central motor system in myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P<.05). Analysis of the interaction between disease and age showed that correlation with age was significantly greater in patients than in controls in bilateral sensorimotor areas and in contralateral parietal areas. Other clinical and MR characteristics did not correlate with fMRI. Functional changes in DM1 may represent compensatory mechanisms such as reorganization and redistribution of functional networks to compensate for ultrastructural and neurochemical changes occurring as part of the accelerated aging process.     

Neurophysiological and functional MRI evidence of reorganization of cortical motor areas in cerebral arteriovenous malformation

Functional magnetic resonance imaging (fMRI) research has shown that brain arteriovenous malformations (AVMs) lead to reorganization of cortical motor areas. Since it is known that blood oxygenation level-dependent signal in fMRI may be influenced by the hemodynamic perturbation associated with the presence of the AVM, in the present study, a combined exploration with fMRI and transcranial magnetic stimulation was performed in a patient with a right rolandic AVM in order to explore the relationship between neuronal and hemodynamic activity. The combined protocol of investigation adopted in this study was able to provide significant information regarding neuronal activity of the different cortical areas that partake to post-lesional reorganization.     

Fruchtsirupe, Marmeladen und Fruchtpr?parate

Ohne Zusammenfassung     

Rapid and selective determination of UV filters in seawater by liquid chromatography-tandem mass spectrometry combined with stir bar sorptive extraction

Fast liquid chromatography coupled to triple-quadrupole tandem mass spectrometry was employed for the determination of six UV filters in seawater. The separation of the analytes was achieved in less than 5 min; polarity switching was used as four of the analytes were ionized in positive mode and the remaining two in negative mode. Two ionization sources were employed and compared: atmospheric pressure chemical ionization (APCI) gave better results than electrospray ionization (ESI) for all analytes, with higher reproducibility and lower detection limits. Therefore APCI was chosen for the determination of the analytes in seawater samples using stir bar sorptive extraction-liquid desorption (SBSE-LD).Quantitative analysis was performed in multiple reaction monitoring (MRM) mode; fragmentation pathways of the analytes with regard to the formation of the MRM ions were also proposed.For the analysis of seawater samples, calibration curves were drawn using SBSE in spiked seawater. All figures of merit of the method were satisfactory; limits of detection were particularly low for the four analytes ionized in positive mode, being in the range 8-31 ng/L. The method was applied to the determination of the six UV filters in seawater samples from Liguria, Italy. Only benzophenone-3 (BP-3) and ethylhexyl methoxycinnamate (EHMC) were measured in the analyzed samples; some of the remaining analytes were also detected but always below the limit of quantitation.