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361.
Arvind Sharma Kanika Arora Harapriya Mohapatra Rakesh K. Sindhu Madalin Bulzan Simona Cavalu Gulsheen Paneshar Hosam O. Elansary Ahmed M. El-Sabrout Eman A. Mahmoud Abdullah Alaklabi 《Molecules (Basel, Switzerland)》2022,27(9)
At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth. 相似文献
362.
Heba A. S. El-Nashar Eman M. El-labbad Mahmood A. Al-Azzawi Naglaa S. Ashmawy 《Molecules (Basel, Switzerland)》2022,27(9)
A new xanthone glycoside, 1,3,5,6-tetrahydroxyxanthone-C-4-β-d-glucopyranoside was isolated from the methanol extract of Mangifera indica leaves (Anacardiaceae) growing in Egypt. The structure was clarified by 1D and 2D-NMR spectroscopic data. The physicochemical properties of the compound such as lipophilicity, solubility, and formulation considerations were predicted via in silico ADMET technique using the SwissADME server. This technique provided Lipinski’s rule of five, such as GIT absorption, distribution, metabolism, and skin permeation. The in vitro inhibitory activities against aging-mediated enzymes such as collagenase, elastase, hyaluronidase, and tyrosinase were assessed. The compound exhibited remarkable anti-collagenase, anti-elastase, anti-hyaluronidase, and anti-tyrosinase effects with IC50 values of 1.06, 419.10, 1.65, and 0.48 µg/mL, respectively, compared to the positive control. The compound showed promising predicted aqueous solubility and reasonable skin penetration suggesting the suitability of the compound for topical formulation as an anti-aging agent for cosmetic preparations. 相似文献
363.
Eman Darweish Hoda M. Marzouk Yasmin M. Fayez Maya S. Eissa 《Journal of separation science》2023,46(1):2200695
Nowadays, Green Analytical Chemistry is widely applied to provide various analytical methods with eco-friendly procedures employing the least toxic, harmful reagents on humans and the environment without affecting the efficacy of the determination. Accordingly, two eco-friendly, accurate, and reliable high-performance thin-layer chromatography-densitometry and high-performance liquid chromatographic methods were established for the determination and separation of two antispasmodic drugs, namely phloroglucinol and trimethylphloroglucinol in their pure, combined dosage form along with phloroglucinol toxic impurity, 3,5-dichloroaniline. For high-performance thin-layer chromatography-densitometry, efficient separation was developed via utilizing the stationary phase of high-performance thin-layer chromatography silica gel 60 F254 plates and developing a system comprising of ethyl acetate-butanol-ammonia in the ratio of 8.0:2.0:0.2, by volume and scanning of the developed bands at 210.0 nm. The subsequent method is isocratic high-performance liquid chromatography with diode array detection in which separation was successively attained using XTerra RP-C18 (250 × 4.6 mm, 5 μm) column as stationary phase and methanol-10.0 mM phosphate buffer, pH 3.7 ± 0.1 as mobile phase in the ratio of 75.0:25.0, v/v at flow rate 1.0 ml/min and scanning at 220.0 nm. The developed liquid chromatography methods were validated according to the International Council for Harmonization guidelines, and all results acknowledged their efficacy. Additionally, the proposed methods worked well for assessing the cited drugs in binary combined commercially available pharmaceutical formulation. The greenness profile of the present methods was assessed and estimated using various assessment tools, namely; Green Analytical Procedure Index, analytical eco-scale method, National Environmental Method Index in addition to Analytical GREEnness tool to evaluate the greenness of the provided methods with a statistical comparison between them to assess the more green ones. 相似文献
364.
Khushbakhat Khan Muhammad Saeed Sameer A. Awad Muhammad Younas Khan Eman M. Khalaf Muhammad Saleh Zaman Vaneeza Aiman Tasmia Irshad Hadia Ahsan 《中国化学会会志》2023,70(1):46-57
The recent study enlightens the synthesis and characterization of zirconia (ZrO2), Fe-doped ZrO2 (Fe@ZrO2), and Ni-doped ZrO2 (Ni@ZrO2) catalysts having new-fangled morphology with tuned band gap as photocatalysts for degradation of textile wastewater dyes methylene blue (MB), malachite green (MG), and their mixtures. SEM imaging of Fe@ZrO2 and Ni@ZrO2 is interestingly varied from ZrO2 as well as doping of transition metals greatly affects the morphology of composites. The optimization study depicts that the pH, time (min) and catalyst amount (g) have a direct relation with degradation efficiency, while the dye concentration (mg/L) has an indirect relation as well. The photocatalytic studies depict that the degradation of MB and MG follows oxidation pathway via hydroxyl radicals (OH•) and holes. Reusability of catalysts corresponds to a little decrease in degradation efficiency in the first two cycles and decreases to about ∼10% (Ni@ZrO2) and ∼12% (Fe@ZrO2) in next three cycles. 相似文献
365.
Zaghloul E. Kandeel Kamal M. Dawood Eman A. Ragab Ahmad M. Farag 《Heteroatom Chemistry》2002,13(3):248-251
The cyanothioacetanilide derivative 3 reacted readily with either α‐halocarbonyl compounds 4 or α‐halodicarbonyl compounds 8 to afford the same thiophene derivatives 6 . Compound 3 also reacted with hydrazonoyl chlorides 12 and 16 and furnished the new polyheterocyles 14 and 17 , respectively. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:248–251, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10024 相似文献