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31.
Murat Ad?var Elvan Ak?n Bohner 《Nonlinear Analysis: Theory, Methods & Applications》2011,74(18):7519-7531
This paper aims to introduce Halanay type inequalities on time scales. By means of these inequalities we derive new global stability conditions for nonlinear dynamic equations on time scales. Giving several examples we show that besides generalization and extension to q-difference case, our results also provide improvements for the existing theory regarding differential and difference inequalities, which are the most important particular cases of dynamic inequalities on time scales. 相似文献
32.
Ceyhan G Çelik C Uruş S Demirtaş İ Elmastaş M Tümer M 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2011,81(1):184-198
In this study, two Schiff base ligands (HL(1) and HL(2)) and their Cu(II), Co(II), Ni(II), Pd(II) and Ru(III) metal complexes were synthesized and characterized by the analytical and spectroscopic methods. Alkane oxidation activities of the metal complexes were studied on cyclohexane as substrate. The ligands and their metal complexes were evaluated for their antimicrobial activity against Corynebacterium xerosis, Bacillus brevis, Bacillus megaterium, Bacillus cereus, Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis (as gram-positive bacteria) and Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Yersinia enterocolitica, Klebsiella fragilis, Saccharomyces cerevisiae, and Candida albicans (as gram-negative bacteria). The antioxidant properties of the Schiff base ligands were evaluated in a series of in vitro tests: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and reducing power activity of superoxide anion radical generated non-enzymatic systems. Electrochemical and thermal properties of the compounds were investigated. 相似文献
33.
Nurdan YAZICI BEKTA Ezgi ERSOY Mehmet BOA Tue BORAN Ercan INAR Gül
ZHAN Ahmet Ceyhan G
REN Esra EROLU
ZKAN 《Turkish Journal of Chemistry》2021,45(5):1621
The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatography-high resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of the plant. Cytotoxic activity was evaluated by MTT assay, and apoptosis induction abilities on human prostate adenocarcinoma (PC-3), and hepatocellular carcinoma (Hep G2) cell lines. Accordingly, major secondary metabolites were found as hederagenin (762 ± 70.10 μg/g) in the leaves dichloromethane (LD), herniarin (167 ± 1.50 μg/g) in fruit dichloromethane (FD), (-)-epicatechin (6538 ± 235.36 μg/g) in the leaves methanol (LM), (-)-epigallocatechin gallate (758 ± 20.46 μg/g) in the fruit methanol (FM), and caffeic acid (370 ± 8.88 μg/g) in the fruit water (FW), and (3313 ± 79.51 μg/g) in the leaves water (LW) extracts. LM exerted strong antioxidant activity in DPPH free (IC50 10.94 ± 0.08 μg/mL), and ABTS cation radicals scavenging (IC50 9.09 ± 0.05 μg/mL) activities. FM exhibited cytotoxic activity with IC50 values of 73.23 ± 3.06 µg/mL and 31.64 ± 2.75 µg/mL on PC-3 and Hep G2 cell lines, respectively. Being the richest extract in terms of quillaic acid (630 ± 18.9 μg/g), which is a well-known cytotoxic triterpenoid with proven apoptosis induction ability on different cells, FM extract showed apoptosis induction activity with 64.75% on PC-3 cells at 50 μg/mL concentration. The study provides promising results about the potential of Hypericum androsaemum on cancer prevention. 相似文献
34.
A macrocyclic diazadioxa dibromo compound was synthesized by ring closure of 1,2-bis-(2-iodoethoxy)-4,5-dibromo-benzene and 1,4-bis-(p-tolylsulfonyl)-ethylenediamine. Its phthalonitrile derivative was obtained by cyano substitution. This diazadioxa macrocyclic dibromo derivative was directly converted into the copper(II) phthalocyanine by reaction with CuCN in tetramethyl urea. Conversion of this phthalonitrile derivative into the metal-free phthalocyanine was accomplished by refluxing with DBU. The zinc(II) phthalocyanine was prepared by reaction of the dinitrile derivative with Zn(OAc)2 in quinoline. The lutetium bis-(phthalocyaninate) complex was obtained by treating the dinitrile derivative with anhydrous lutetium acetate and DBU in 1-hexanol. The new compounds were characterized by elemental analyses and IR, 1H NMR, mass, UV/Vis, and ESR spectra. 相似文献
35.
Summary. A macrocyclic diazadioxa dibromo compound was synthesized by ring closure of 1,2-bis-(2-iodoethoxy)-4,5-dibromo-benzene and 1,4-bis-(p-tolylsulfonyl)-ethylenediamine. Its phthalonitrile derivative was obtained by cyano substitution. This diazadioxa macrocyclic
dibromo derivative was directly converted into the copper(II) phthalocyanine by reaction with CuCN in tetramethyl urea. Conversion
of this phthalonitrile derivative into the metal-free phthalocyanine was accomplished by refluxing with DBU. The zinc(II) phthalocyanine was prepared by reaction of the dinitrile derivative with Zn(OAc)2 in quinoline. The lutetium bis-(phthalocyaninate) complex was obtained by treating the dinitrile derivative with anhydrous lutetium acetate and DBU in 1-hexanol. The new compounds were characterized by elemental analyses and IR, 1H NMR, mass, UV/Vis, and ESR spectra.
Received May 8, 2001. Accepted (revised) June 25, 2001 相似文献
36.
In this article, we establish some new criteria for the oscillation of fourth-order nonlinear delay differential equations of the formprovided that the second-order equationis nonoscillatory or oscillatory.
相似文献
$$(r_2(t)(r_1(t)(y''(t))^\alpha)')' + p(t)(y''(t))^\alpha + q(t)f(y(g(t))) = 0$$
$$(r_2(t)z'(t))') + \frac{p(t)}{r_1(t)}z(t) = 0$$
37.
A. M. Şenışık Ç. İçhedef A. Y. Kılçar E. Uçar K. Arı D. Göksoy Y. Parlak Bedriye Elvan Sayıt Bilgin S. Teksöz 《Journal of Radioanalytical and Nuclear Chemistry》2018,316(2):457-463
This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [18F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18F]FDG solution. The radiolabeled product ([18F]FDG-GlyGly) was obtained with 98.65?±?0.35% yield without any purification step which makes this method more attractive for 18F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18F]FDG tagged GlyGly in vivo. 相似文献
38.
Elvan Üstün Aykut Özgür Kübra A. Coşkun Serpil Demir İsmail Özdemir Yusuf Tutar 《Journal of Coordination Chemistry》2016,69(22):3384-3394
Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown of heme into CO, ferrous iron, and biliverdin. CO induces HO-1 and inhibits cell proliferation. Cancer cells exposed to several stress factors (hypoxia, reactive oxygen species, cis-platin, and oxidative stress), and HO-1 displays cytoprotective role against oxidative stress and inhibits apoptosis, metastases, angiogenesis, and cell proliferation processes. Therefore, metal containing CO-releasing molecules (CORMs) have been designed as an effective cancer treatment strategy. CORMs are responsible for releasing controlled amounts of CO to cells and tissues. Thus, we synthesized [Mn(CO)3(bpy)L]X manganese containing CORMs [bpy = 2,2′-bipyridine, X = hexafluorophosphate (PF6), trifluoromethanesulfonate (OTf), L = imidazole, methylimidazole, benzimidazole, N-benzylbenzimidazole, N-(4-chlorobenzyl)benzimidazole] to release CO in human invasive ductal breast (MCF-7) cell line. In vitro experiments indicated that the compounds inhibited cell proliferation and exhibited cytotoxic effect on breast cancer cells. Moreover, side groups of the compounds enhanced the anticancer effects in MCF-7 cell line. These manganese containing CORMs gave promising results and may be used as a drug template for effective treatment of invasive ductal breast carcinoma. 相似文献
39.
Periodically data envelopment analysis (DEA) is conducted on values that include estimated proportions, such as defect, satisfaction, mortality, or adverse event rates computed from samples. This occurs frequently in healthcare and public sector analysis where proportions frequently are estimated from partial samples. These estimates can produce statistically biased and variable estimates of DEA results, even as sample sizes become fairly large. This paper discusses several approaches to these problems, including Monte Carlo (MC), bootstrapping, chance constrained, and optimistic/pessimistic DEA methods. The performance of each method was compared using previously published data for fourteen Florida juvenile delinquency programs whose two of three inputs and one output were proportions. The impact of sample size and number of estimated rates also were investigated. In most cases, no statistically significant differences were found between the true DEA scores and the midpoints of optimistic/pessimistic, MC, and bootstrap intervals, the latter two after bias correction. True DEA results are strongly correlated with those produced by the MC (r=0.9865, p<0.001), chance constraint (r=0.9536,p<0.001), bootstrapping (r=0.9368,p<0.001), and optimistic/pessimistic (r=0.6799,p<0.001) approaches. While all methods perform fairly well, the MC approach tends to produce slightly better results and be fairly easy to implement. 相似文献
40.
In this paper, we obtained a novel poly(vanillinato potassium) complex (PVP) as a single crystal and characterized by analytical and spectroscopic methods. A single crystal of the PVP was obtained from the acetone solution. X-ray structural data show that crystals contain polymeric K+ complex of vanillin. Each potassium ion in the polymeric structure is identical and seven-coordinate, bonded to two methoxy, two phenoxy and three aldehyde oxygen atoms from four vaniline molecules. Two aldehyde oxygen atoms are bridging between potassium ions. It crystallizes in the monoclinic system, space group P21/c, with lattice parameters a=9.6215(10) Å, b=17.4139(19) Å, c=9.6119(10) Å, β=100.457(2)° and Z=4. Thermal properties of the PVP were investigated by TGA, DTA and DSC methods. The electrochemical properties of the complex were studied in different solvents and at various scan rates. The luminescence properties of the complex in different solvents and at different pH values have been investigated. The results show that the complex exhibits more efficient luminescence property in CH3CN and n-butanol. 相似文献