Experimental and numerical studies of intestinal frictions for propulsive force optimisation of a vibro-impact capsule system

This paper studies the intestinal frictions acting on a millimetre-scale self-propelled capsule (26 mm in length and 11 mm in diameter) for small bowel endoscopy by considering different capsule–intestine contact conditions under a wide range of capsule’s progression speeds. According to the experimental results, intestinal frictions vary from 7 mN to 4.5 N providing us with a guidance for designing the propelling mechanism of the controllable capsule endoscope. Our calculations show that the proposed vibro-impact mechanism can perform as a force magnifier generating a much larger propulsive force on the capsule than its original driving force. Therefore, the self-propelled capsule is capable of moving in the small intestine under a wide range of friction variation.

     

Scalable gas-phase processes to create nanostructured particles

The properties of nanoparticles are often different from those of larger grains of the same solid material because of their very large specific surface area. This enables many novel applications, but properties such as agglomeration can also hinder their potential use. By creating nanostructured particles one can take optimum benefit from the desired properties while minimizing the adverse effects. We aim at developing high-precision routes for scalable production of nanostructured particles. Two gas-phase synthesis routes are explored. The first one - covering nanoparticles with a continuous layer - is carried out using atomic layer deposition in a fluidized bed. Through fluidization, the full surface area of the nanoparticles becomes available. With this process, particles can be coated with an ultra-thin film of constant and well-tunable thickness. For the second route - attaching nanoparticles to larger particles - a novel approach using electrostatic forces is demonstrated. The micron-sized particles are charged with one polarity using tribocharging. Using electrospraying, a spray of charged nanoparticles with opposite polarity is generated. Their charge prevents agglomeration, while it enhances efficient deposition at the surface of the host particle. While the proposed processes offer good potential for scale-up, further work is needed to realize large-scale processes.     

Use of a surfactant in the determination of arsenic by flow injection hydride generation atomic absorption spectrometry

The possible benefits of the addition of an anionic surfactant, didodecyldimethylammonium bromide, in the determination of arsenic, by flow injection hydride generation atomic absorption spectrometry using a flame-heated quartz tube atomizer, were studied in the light of previous reports concerning the effects of surfactants on chemical vapor generation procedures. Concentrations of arsenic between 5 and 30 μg l⁻¹ were used. Calibrations in the presence and absence of the surfactant in the sample solution were not significantly different, either for the case where vesicles were formed in the presence of the analyte or where they were preformed in the surfactant solution and then added to the analyte. The surfactant had no effect on recoveries in the presence of copper, nickel or bismuth. The addition of the surfactant to the acid carrier and/or borohydride streams had no effect. It is proposed that there may be a greater role for surfactants in the improvement of the processes by which the hydride is transferred to the bulk gas phase than has been attributed in previous reports on this subject.     

Characterization of a Bio-sourced,Fluorescent, Ratiometric pH Indicator with Alkaline pKa

Utilizing organisms as sources of fluorophores relieves the demand for petroleum feedstock in organic synthesis of fluorescent products, and endophytic fungi provide a promising vein for natural fluorescent products. We report the characterization of a pH-responsive fluorophore from an endophytic fungus isolated from sand pine. The endogenous fluorescence of the live organism was measured using fluorescence microscopy. Computational interpretation of the spectra was accomplished with time-dependent density functional theory methods. The combined use of experimental and theoretically predicted spectra revealed the pH equilibria and photoexcited tautomerization of the natural product, 5-methylmellein. This product shows promise both as a stand-alone pH-indicating fluorophore, with alkaline pK_a, and as "green" feedstock for synthesis of custom fluorophores.     

Algebraic quantum kk-theory

Let 𝒢 be an algebraic quantum group. We introduce an equivariant algebraic kk-theory for 𝒢-module algebras. We study an adjointness theorem related with smash product and trivial action. We also discuss a duality property.     

Automatic peak assignment and visualisation of copolymer mass spectrometry data using the ‘genetic algorithm’

Copolymer analysis is vitally important as the materials have a wide variety of applications due to their tunable properties. Processing mass spectrometry data for copolymer samples can be very complex due to the increase in the number of species when the polymer chains are formed by two or more monomeric units. In this paper, we describe the use of the genetic algorithm for automated peak assignment of copolymers synthesised by a variety of polymerisation methods. We find that in using this method we are able to easily assign copolymer spectra in a few minutes and visualise them into heat maps. These heat maps allow us to look qualitatively at the distribution of the chains, by showing how they alter with different polymerisation techniques, and by changing the initial copolymer composition. This methodology is simple to use and requires little user input, which makes it well suited for use by less expert users. The data outputted by the automatic assignment may also allow for more complex data processing in the future.     

Imaging of human lens lipids by desorption electrospray ionization mass spectrometry

The lipid composition of the human lens is distinct from most other tissues in that it is high in dihydrosphingomyelin and the most abundant glycerophospholipids in the lens are unusual 1-O-alkyl-ether linked phosphatidylethanolamines and phosphatidylserines. In this study, desorption electrospray ionization (DESI) mass spectrometry-imaging was used to determine the distribution of these lipids in the human lens along with other lipids including, ceramides, ceramide-1-phosphates, and lyso 1-O-alkyl ethers. To achieve this, 25 μm lens slices were mounted onto glass slides and analyzed using a linear ion-trap mass spectrometer equipped with a custom-built, 2-D automated DESI source. In contrast to other tissues that have been previously analyzed by DESI, the presence of a strong acid in the spray solvent was required to desorb lipids directly from lens tissue. Distinctive distributions were observed for [M + H]⁺ ions arising from each lipid class. Of particular interest were ionized 1-O-alkyl phosphatidylethanolamines and phosphatidylserines, PE (18:1e/18:1), and PS (18:1e/18:1), which were found in a thin ring in the outermost region of the lens. This distribution was confirmed by quantitative analysis of lenses that were sectioned into four distinct regions (outer, barrier, inner, and core), extracted and analyzed by electrospray ionization tandem mass spectrometry. DESI-imaging also revealed a complementary distribution for the structurally-related lyso 1-O-alkyl phosphatidylethanolamine, LPE (18:1e), which was localized closer to the centre of the lens. The data obtained in this study indicate that DESI-imaging is a powerful tool for determining the spatial distribution of human lens lipids.     

Chemically grafted carbon nanotube surface coverage gradients

Two approaches to producing gradients of vertically aligned single-walled carbon nanotubes (SWCNTs) on silicon surfaces by chemical grafting are presented here. The first approach involves the use of a porous silicon (pSi) substrate featuring a pore size gradient, which is functionalized with 3-aminopropyltriethoxysilane (APTES). Carboxylated SWCNTs are then immobilized on the topography gradient via carbodiimide coupling. Our results show that as the pSi pore size and porosity increase across the substrate the SWCNT coverage decreases concurrently. In contrast, the second gradient is an amine-functionality gradient produced by means of vapor-phase diffusion of APTES from a reservoir onto a silicon wafer where APTES attachment changes as a function of distance from the APTES reservoir. Carboxylated SWCNTs are then immobilized via carbodiimide coupling to the amine-terminated silicon gradient. Our observations confirm that with decreasing APTES density on the surface the coverage of the attached SWCNTs also decreases. These gradient platforms pave the way for the time-efficient optimization of SWCNT coverage for applications ranging from field emission to water filtration to drug delivery.