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31.
Hydrodynamic flow and electric currents through model porous media were investigated. The transport rates through the individual pathways of the pore network are determined by the local width of the pore channels and by the driving mechanism. The model objects represent quasi two-dimensional random site percolation clusters. The calculated design was realized by milling the structure in polystyrene sheets. Velocity maps of stationary flow and current density maps of stationary currents through the cluster were acquired by magnetic resonance imaging methods. The findings were compared to the results of numerical simulations based on the same structure. Since the difference in the transport patterns of the different driving mechanisms are expected to be more pronounced in smaller pore spaces, ultra deep X-ray lithography has been used for the fabrication of downsized model objects with a spatial resolution of better than 50 microm and an aspect ratio as large as 20. First results obtained with these objects are reported. 相似文献
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Carter EB Culver SL Fox PA Goode RD Ntai I Tickell MD Traylor RK Hoffman NW Davis JH 《Chemical communications (Cambridge, England)》2004,(6):630-631
The anions of the sweeteners saccharin and acesulfame form ionic liquids when paired with a variety of organic cations. 相似文献
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Elke Debie Lize Jaspers Patrick Bultinck Wouter Herrebout Benjamin Van Der Veken 《Chemical physics letters》2008,450(4-6):426-430
It is shown how the presence of a chiral compound in solution induces chirality in the surrounding solvent molecules. Using Vibrational Circular Dichroism on camphor dissolved in deuterated chloroform, it is found that the C–D stretch in the latter indeed becomes VCD active. The experimental results agree with ab initio computed spectra for 1:1 associations between the solvent and solute. 相似文献
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Tim Desmet T. Billiet Elke Berneel Ria Cornelissen David Schaubroeck Etienne Schacht Peter Dubruel 《Macromolecular bioscience》2010,10(12):1484-1494
In the last decade, substantial research in the field of post‐plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly‐ε‐caprolactone (PCL) films were subjected to a dielectric barrier discharge Ar‐plasma followed by the grafting of 2‐aminoethyl methacrylate (AEMA) under UV‐irradiation. X‐ray photoelectron spectroscopy (XPS) confirmed the presence of nitrogen. The ninhydrin assay demonstrated, both quantitatively and qualitatively, the presence of free amines on the surface. Confocal fluorescence microscopy (CFM), atomic force microscopy (AFM) and scanning electron microscopy (SEM) were used to visualise the grafted surfaces, indicating the presence of pAEMA. Static contact angle (SCA) measurements indicated a permanent increase in hydrophilicity. Furthermore, the AEMA grafted surfaces were applied for comparing the physisorption and covalent immobilisation of gelatin. CFM demonstrated that only the covalent immobilisation lead to a complete coverage of the surface. Those gelatin‐coated surfaces obtained were further coated using fibronectin. Osteosarcoma cells demonstrated better cell‐adhesion and cell‐viability on the modified surfaces, compared to the pure PCL films.
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A Hot‐Segment‐Based Approach for the Design of Cross‐Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self‐Assembly 下载免费PDF全文
Dr. Erika Andreetto Dipl.‐Chem. Eleni Malideli Dr. Li‐Mei Yan Dipl.‐Ing. Michael Kracklauer MSc. Karine Farbiarz Dipl.‐Chem. Marianna Tatarek‐Nossol Prof. Dr. Gerhard Rammes M. Sc. Elke Prade Tatjana Neumüller Dr. Andrea Caporale M. Sc. Anna Spanopoulou B. Sc. Maria Bakou Prof. Dr. Bernd Reif Prof. Dr. Aphrodite Kapurniotu 《Angewandte Chemie (International ed. in English)》2015,54(44):13095-13100
The design of inhibitors of protein–protein interactions mediating amyloid self‐assembly is a major challenge mainly due to the dynamic nature of the involved structures and interfaces. Interactions of amyloidogenic polypeptides with other proteins are important modulators of self‐assembly. Here we present a hot‐segment‐linking approach to design a series of mimics of the IAPP cross‐amyloid interaction surface with Aβ (ISMs) as nanomolar inhibitors of amyloidogenesis and cytotoxicity of Aβ, IAPP, or both polypeptides. The nature of the linker determines ISM structure and inhibitory function including both potency and target selectivity. Importantly, ISMs effectively suppress both self‐ and cross‐seeded IAPP self‐assembly. Our results provide a novel class of highly potent peptide leads for targeting protein aggregation in Alzheimer’s disease, type 2 diabetes, or both diseases and a chemical approach to inhibit amyloid self‐assembly and pathogenic interactions of other proteins as well. 相似文献