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131.
132.
Characterization of multiple fragmentation pathways initiated by collision‐induced dissociation of multifunctional anions formed by deprotonation of 2‐nitrobenzenesulfonylglycine
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Tara E. Tovstiga Elizabeth A. L. Gillis J. Stuart Grossert Robert L. White 《Journal of mass spectrometry : JMS》2014,49(2):168-177
The correlation of anion structure with the fragmentation behavior of deprotonated nitrobenzenesulfonylamino acids was investigated using tandem mass spectrometry, isotopic labeling and computational methods. Four distinct fragmentation pathways resulting from the collision‐induced dissociation (CID) of deprotonated 2‐nitrobenzenesulfonylglycine (NsGly) were characterized. The unusual loss of the aryl nitro substituent as HONO was the lowest energy process. Subsequent successive losses of CO, HCN and SO2 indicated that an ortho cyclization reaction had accompanied loss of HONO. Other pathways involving rearrangement of the ionized sulfonamide group, dual bond cleavage and intramolecular nucleophilic displacement were proposed to account for the formation of phenoxide, arylsulfinate and arylsulfonamide product ions at higher collision energies. The four distinct fragmentation pathways were consistent with precursor–product relationships established by CID experiments, isotopic labeling results and the formation of analogous product ions from 2,4‐dinitrobenzenesulfonylglycine and the Ns derivatives of alanine and 2‐aminoisobutyric acid. The computations confirmed a low barrier for ortho cyclization with loss of HONO and feasible energetics for each reaction step in the four pathways. Computations also indicated that three of the fragmentation pathways started from NsGly ionized at the carboxyl group. Overall, the pathways identified for the fragmentation of the NsGly anion differed from processes reported for anions containing a single functional group, demonstrating the importance of functional group interactions in the fragmentation pathways of multifunctional anions. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
133.
Nickel‐Catalyzed Mizoroki–Heck Reaction of Aryl Sulfonates and Chlorides with Electronically Unbiased Terminal Olefins: High Selectivity for Branched Products
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Sarah Z. Tasker Dr. Alicia C. Gutierrez Prof. Timothy F. Jamison 《Angewandte Chemie (International ed. in English)》2014,53(7):1858-1861
Achieving high selectivity in the Heck reaction of electronically unbiased alkenes has been a longstanding challenge. Using a nickel‐catalyzed cationic Heck reaction, we were able to achieve excellent selectivity for branched products (≥19:1 in all cases) over a wide range of aryl electrophiles and aliphatic olefins. A bidentate ligand with a suitable bite angle and steric profile was key to obtaining high branched/linear selectivity, whereas the appropriate base suppressed alkene isomerization of the product. Although aryl triflates are traditionally used to access the cationic Heck pathway, we have shown that, by using triethylsilyl trifluoromethanesulfonate, we can effect a counterion exchange of the catalytic nickel complex, such that cheaper and more stable aryl chlorides, mesylates, tosylates, and sulfamates can be used to yield the same branched products with high selectivity. 相似文献
134.
Back Cover: Synthesis,Characterization, Self‐Assembly,Gelation, Morphology and Computational Studies of Alkynylgold(III) Complexes of 2,6‐Bis(benzimidazol‐2′‐yl)pyridine Derivatives (Chem. Eur. J. 32/2014)
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135.
Corrigendum: Combined Two‐Photon Excitation and d→f Energy Transfer in a Water‐Soluble IrIII/EuIII Dyad: Two Luminescence Components from One Molecule for Cellular Imaging
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136.
Haq Nawaz Paulo A. R. Pires Thaís A. Bioni Elizabeth P. G. Arêas Omar A. El Seoud 《Cellulose (London, England)》2014,21(3):1193-1204
Rate constants for the acetylation of microcrystalline cellulose (MCC), by ethanoic anhydride in the presence of increasing concentrations of the ionic liquid (IL), 1-allyl-3-methylimidazolium chloride in dipolar aprotic solvents (DAS), N,N-dimethylacetamide (DMAC), and acetonitrile (MeCN), have been calculated from conductivity data. The third order rate constants showed a linear dependence on [IL]. We explain this result by assuming that the reacting cellulose is hydrogen-bonded to the IL. This is corroborated by kinetic data of the acetylation of cyclohexylmethanol, FTIR of the latter compound and of cellobiose in mixtures of IL/DAS, and conductivity of the binary solvent mixtures in absence, and presence of MCC. Cellulose acetylation is faster in IL/DMAC than in IL/MeCN; this difference is explained based on solvatochromic data (empirical polarity and basicity) and molecular dynamics simulations. Results of the latter indicate hydrogen-bond formation between the hydroxyl groups of the anhydroglucose unit of MCC, (Cl?) of the IL, and the dipole of the DMAC. Under identical experimental conditions, acetylation in IL/DMAC is faster than that in LiCl/DMAC (2.7–8 times), due to differences in the enthalpies and entropies of activation. 相似文献
137.
Dr. Stephen J. Harley Dr. Elizabeth A. Glascoe Dr. James P. Lewicki Dr. Robert S. Maxwell 《Chemphyschem》2014,15(9):1809-1820
Water‐vapor‐uptake experiments were performed on a silica‐filled poly(dimethylsiloxane) (PDMS) network and modeled by using two different approaches. The data was modeled by using established methods and the model parameters were used to predict moisture uptake in a sample. The predictions are reasonably good, but not outstanding; many of the shortcomings of the modeling are discussed. A high‐fidelity modeling approach is derived and used to improve the modeling of moisture uptake and diffusion. Our modeling approach captures the physics and kinetics of diffusion and adsorption/desorption, simultaneously. It predicts uptake better than the established method; more importantly, it is also able to predict outgassing. The material used for these studies is a filled‐PDMS network; physical interpretations concerning the sorption and diffusion of moisture in this network are discussed. 相似文献
138.
Li Xing Brajesh Rai Elizabeth A. Lunney 《Journal of computer-aided molecular design》2014,28(1):13-23
Protein kinases are the second most prominent group of drug targets, after G-protein-coupled receptors. Despite their distinct inhibition mechanisms, the majority of kinase inhibitors engage the conserved hydrogen bond interactions with the backbone of hinge residues. We mined Pfizer internal crystal structure database (CSDb) comprising of several thousand of public as well as internal X-ray binary complexes to compile an inclusive list of hinge binding scaffolds. The minimum ring scaffolds with directly attached hetero-atoms and functional groups were extracted from the full compounds by applying a rule-based filtering procedure employing a comprehensive annotation of ATP-binding site of the human kinase complements. The results indicated large number of kinase inhibitors of diverse chemical structures are derived from a relatively small number of common scaffolds, which serve as the critical recognition elements for protein kinase interaction. Out of the nearly 4,000 kinase-inhibitor complexes in the CSDb we identified approximately 600 unique scaffolds. Hinge scaffolds are overwhelmingly flat with very little sp3 characteristics, and are less lipophilic than their corresponding parent compounds. Examples of the most common as well as the uncommon hinge scaffolds are presented. Although the most common scaffolds are found in complex with multiple kinase targets, a large number of them are uniquely bound to a specific kinase, suggesting certain scaffolds could be more promiscuous than the others. The compiled collection of hinge scaffolds along with their three-dimensional binding coordinates could serve as basis set for hinge hopping, a practice frequently employed to generate novel invention as well as to optimize existing leads in medicinal chemistry. 相似文献
139.
Augustine Elizabeth Desigan N. Pandey N. K. Joshi J. B. 《Journal of Radioanalytical and Nuclear Chemistry》2020,324(1):211-218
Journal of Radioanalytical and Nuclear Chemistry - In the present study, the dissolution kinetics of UO2 pellets in nitric acid has been investigated. Kinetic rate expressions based on... 相似文献
140.
Chongqing Wang Christopher Lambert Maurice Hauser Adrian Deuschmann Dr. Carsten Zeilinger Prof. Dr. Klemens Rottner Prof. Dr. Theresia E. B. Stradal Prof. Dr. Marc Stadler Dr. Elizabeth J. Skellam Prof. Dr. Russell J. Cox 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(60):13578-13583
Mutasynthesis of pyrichalasin H from Magnaporthe grisea NI980 yielded a series of unprecedented 4′-substituted cytochalasin analogues in titres as high as the wild-type system (≈60 mg L−1). Halogenated, O-alkyl, O-allyl and O-propargyl examples were formed, as well as a 4′-azido analogue. 4′-O-Propargyl and 4′-azido analogues reacted smoothly in Huisgen cycloaddition reactions, whereas p-Br and p-I compounds reacted in Pd-catalysed cross-coupling reactions. A series of examples of biotin-linked, dye-linked and dimeric cytochalasins was rapidly created. In vitro and in vivo bioassays of these compounds showed that the 4′-halogenated and azido derivatives retained their cytotoxicity and antifungal activities; but a unique 4′-amino analogue was inactive. Attachment of larger substituents attenuated the bioactivities. In vivo actin-binding studies with adherent mammalian cells showed that actin remains the likely intracellular target. Dye-linked compounds revealed visualisation of intracellular actin structures even in the absence of phalloidin, thus constituting a potential new class of actin-visualisation tools with filament-barbed end-binding specificity. 相似文献