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661.
(R)(S)(E)-3,7-dimethyl-2-octene-1,8-dioic acid, (R)(S)(E)-1, also named callosobruchusic acid, has been synthetized in five steps using a simple reaction sequence based on the zirconium-catalyzed methylalumination of commercially available 4-pentyn-1-ol, 2a, or its O-tert-butyldimethylsilyl ether, 2b. 相似文献
662.
Elisabetta Mazzotta Cosimino Malitesta Eleonora Margapoti 《Analytical and bioanalytical chemistry》2013,405(11):3587-3592
The electrochemical behavior of bisphenol A (BPA) was studied on poly(3,4-ethylenedioxythiophene) (PEDOT)-modified glassy carbon electrodes by cyclic voltammetry. It was observed that BPA oxidation on PEDOT film produced a BPA polymer (pBPA) showing excellent redox activity with anodic and cathodic peaks at 0.15 and 0.01 V, respectively; the former being evaluated for BPA electrochemical sensing. The amount of deposited pBPA has been estimated by electrochemical and spectroscopic analysis by X-ray photoelectron spectroscopy. The effect of scan rate and pH on the oxidation of pBPA film has been studied. The oxidation current was found to vary linearly with BPA concentration in the range 90–410 μM, and a detection limit of 55 μM was evaluated. Results of BPA amperometric detection have also been collected by using a repetitive potential step program to give a linear response to BPA in the concentration range 40–410 μM with a detection limit of 22 μM and a sensitivity of 1.57 μAμM?1?cm?2. The developed sensor showed satisfactory reproducibility and anti-interference properties and was successfully applied to BPA determination in mineral water samples. 相似文献
663.
The atropisomeric structure of 4,5-dihydro-3H-dinaphtho[2,1-c;1',2'-e]phosphepine is the common axially chiral scaffold of a library of monophosphine ligands nicknamed BINEPINES that have shown a quite remarkable stereoselection efficiency in a broad variety of enantioselective reactions involving the formation of new C-H or C-C or C-X bonds. In this critical review the properties and scope of this type of chiral ligands are illustrated (70 references). 相似文献
664.
Francesca Caramia Caterina Mainero Francesca Gragnani Emanuele Tinelli Marco Fiorelli Vanessa Ceschin Patrizia Pantano Elisabetta Bucci Veronica Barra Luigi Bozzao Giovanni Antonini 《Magnetic resonance imaging》2010
Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P<.05). Analysis of the interaction between disease and age showed that correlation with age was significantly greater in patients than in controls in bilateral sensorimotor areas and in contralateral parietal areas. Other clinical and MR characteristics did not correlate with fMRI. Functional changes in DM1 may represent compensatory mechanisms such as reorganization and redistribution of functional networks to compensate for ultrastructural and neurochemical changes occurring as part of the accelerated aging process. 相似文献
665.
Elisabetta Ranucci Paolo Ferruti Vittorio Ferrari Daniele Marioli Andrea Taroni 《Macromolecular Symposia》1996,109(1):89-103
Crosslinked hydrophilic polymers of different chemical structures can be used as sensor coatings for the detection of gaseous analytes. If their crosslink density is low, these materials behave in aqueous media as soft hydrogels with high swelling capacity. From a physico-mechanical standpoint, they are amorphous rubber-like materials, with high flexibility of their macromolecular chains. This property is particularly significant in view of applications in the sensors field, because it favours diffusion of the analyte molecules through the coating layer. This paper deals with the application of poly(ethylene glycols) (PEG)- and poly(N-vinylpyrrolidinone) (PVP)-based crosslinked resins as relative humidity (RH) sorbing materials, and of a poly(amidoamine)(PAA)-based resin as SO2-sorbing material. The electronic devices used for evaluating the sorption capability of these polymeric coatings were gravimetric resonant sensors. Resins of various crosslink density, and therefore of various swelling ratios in water, were purposely prepared and characterized. Thin coating, layers, prepared by casting from dilute aqueous suspensions of the resins, previously micronized in water, were used for sorption experiments. All experiments were performed in controlled RH and temperature environments. 相似文献
666.
Niccol Chiaramonte Alessio Gabellini Andrea Angeli Gianluca Bartolucci Laura Braconi Silvia Dei Elisabetta Teodori Claudiu T. Supuran Maria Novella Romanelli 《Molecules (Basel, Switzerland)》2022,27(2)
A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (KA values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives (1, 3a and 22) displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII. 相似文献
667.
Hassan Dalil Monique Biesemans Rudolph Willem Luigi Angiolini Elisabetta Salatelli Daniele Caretti NikolasA. Chaniotakis Katerina Perdikaki 《Helvetica chimica acta》2002,85(3):852-866
Polystyrene copolymers of the type ( P −H)1−x( P −(CH2)n−COOSnR3)x containing [(1‐oxoalkyl)oxy]triphenylstannane or tributyl[(1‐oxoalkyl)oxy]stannanes as side chains ( P −H=styrene; P −(CH2)n−COOSnR3 =para‐substituted styrene‐like monomeric unit with R=Ph (x=0.1), Bu (x=0.5); n=2–4) were investigated. The tributyl[(1‐oxoalkyl)oxy]stannane copolymer was prepared by direct conversion of the corresponding copolymeric methyl esters with hexabutyldistannoxane. By contrast, the [(1‐oxoalkyl)oxy]triphenylstannane copolymer could be prepared only by a procedure involving two reaction steps consisting of a preliminary hydrolysis of the related methyl ester ( P −H)1‐x( P −(CH2)n−COOMe)x followed by functionalization of the corresponding poly(carboxylic acid) ( P −H)1‐x( P −(CH2n−COOH)x with hydroxytriphenylstannane. Attempts to directly convert the methyl ester with hydroxytriphenylstannane or hexaphenyldistannoxane led to the formation of uncompletely functionalized product. The structure of the stannane‐functionalized polymers was investigated in solution and solid state by NMR, IR, and thermal analysis. The tributylstannane and triphenylstannane copolymers were assessed as chloride‐selective anion carriers in polymeric‐liquid‐membrane potentiometric ion‐selective electrodes. 相似文献
668.
Andrea Sartori Kelly Bugatti Elisabetta Portioli Monica Baiula Irene Casamassima Agostino Bruno Francesca Bianchini Claudio Curti Franca Zanardi Lucia Battistini 《Molecules (Basel, Switzerland)》2021,26(19)
Integrin α4β1 belongs to the leukocyte integrin family and represents a therapeutic target of relevant interest given its primary role in mediating inflammation, autoimmune pathologies and cancer-related diseases. The focus of the present work is the design, synthesis and characterization of new peptidomimetic compounds that are potentially able to recognize α4β1 integrin and interfere with its function. To this aim, a collection of seven new cyclic peptidomimetics possessing both a 4-aminoproline (Amp) core scaffold grafted onto key α4β1-recognizing sequences and the (2-methylphenyl)ureido-phenylacetyl (MPUPA) appendage, was designed, with the support of molecular modeling studies. The new compounds were synthesized through SPPS procedures followed by in-solution cyclization maneuvers. The biological evaluation of the new cyclic ligands in cell adhesion assays on Jurkat cells revealed promising submicromolar agonist activity in one compound, namely, the c[Amp(MPUPA)Val-Asp-Leu] cyclopeptide. Further investigations will be necessary to complete the characterization of this class of compounds. 相似文献
669.
Margaretha Sderqvist Lindblad Elisabetta Ranucci Ann‐Christine Albertsson 《Macromolecular rapid communications》2001,22(12):962-967
Hemicellulose/poly(2‐hydroxyethyl methacrylate) (PHEMA)‐based hydrogels were prepared by the radical polymerization of HEMA with hemicellulose purposely modified with well‐defined amounts of methacrylic functions using a redox initiator system. Oligomeric hydrosoluble hemicelluloses produced from spruce chips were used for modification studies. The chemical modification of hemicellulose was performed with 2‐[(1‐imidazolyl)formyloxy]ethyl methacrylate as a modifying agent and triethylamine as the catalyst. The kinetics of the modification reaction was monitored by means of 1H NMR spectroscopy. The resulting hydrogels obtained after a 30 min reaction were homogeneous, elastic, and transparent materials. 相似文献
670.
Elisabetta Rubini Marco Minacori Giuliano Paglia Alberto Macone Silvia Chichiarelli Fabio Altieri Margherita Eufemi 《Molecules (Basel, Switzerland)》2021,26(23)
The β-isomer of hexachlorocyclohexane (β-HCH) is a globally widespread pollutant that embodies all the physicochemical characteristics of organochlorine pesticides, constituting an environmental risk factor for a wide range of noncommunicable diseases. Previous in vitro studies from our group disclosed the carcinogenic potential of β-HCH, which contributes to neoplastic transformation by means of multifaceted intracellular mechanisms. Considering the positive evidence regarding the protective role of natural bioactive compounds against pollution-induced toxicity, micronutrients from olive and tomato endowed with the capability of modulating β-HCH cellular targets were tested. For this purpose, the solution obtained from a patented food supplement (No. EP2851080A1), referred to as Tomato and Olive Bioactive Compounds (TOBC), was administered to the androgen-sensitive prostate cancer cells LNCaP and different biochemical and cellular assays were performed to evaluate its efficiency. TOBC shows a dose-dependent significant chemoprotection by contrasting β-HCH-induced intracellular responses such as STAT3 and AhR activation, disruption of AR signaling, antiapoptotic and proliferative activity, and increase in ROS production and DNA damage. These experimental outcomes identified TOBC as a suitable functional food to be included in a diet regimen aimed at defending cells from β-HCH negative effects, recommending the development of tailored enriched formulations for exposed individuals. 相似文献