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161.
Pier Giorgio Righetti Elisabetta Gianazza Cecilia Gelfi 《Separation & Purification Reviews》2013,42(2):105-169
Abstract The technique of isoelectric focusing (IEF) via immobilized pH gradients (IPG) was first announced to the scientific community at a meeting of the International Electrophoresis Society in Athens, April 1982, as the result of an intensive collaborative effort [1]. In five years, the technique has been extensively developed in three fundamental aspects: analytical, preparative and as a first dimension of two-dimensional (2-D) maps. The merits and, recently, the flaws of the IPG technique have been evaluated and recognized, so that at the present writing we feel it is ready for successful introduction in most life-science laboratories. 相似文献
162.
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164.
Damage processes in thermoviscoelastic materials with damage‐dependent thermal expansion coefficients
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Christian Heinemann Elisabetta Rocca 《Mathematical Methods in the Applied Sciences》2015,38(18):4587-4612
In this paper, we prove existence of global in time weak solutions for a highly nonlinear PDE system arising in the context of damage phenomena in thermoviscoelastic materials. The main novelty of the present contribution with respect to the ones already present in the literature consists in the possibility of taking into account a damage‐dependent thermal expansion coefficient. This term implies the presence of nonlinear coupling terms in the PDE system, which make the analysis more challenging. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
165.
Federica Rizzi Rachele Castaldo Tiziana Latronico Pierluigi Lasala Gennaro Gentile Marino Lavorgna Marinella Striccoli Angela Agostiano Roberto Comparelli Nicoletta Depalo Maria Lucia Curri Elisabetta Fanizza 《Molecules (Basel, Switzerland)》2021,26(14)
Mesoporous silica nanostructures (MSNs) attract high interest due to their unique and tunable physical chemical features, including high specific surface area and large pore volume, that hold a great potential in a variety of fields, i.e., adsorption, catalysis, and biomedicine. An essential feature for biomedical application of MSNs is limiting MSN size in the sub-micrometer regime to control uptake and cell viability. However, careful size tuning in such a regime remains still challenging. We aim to tackling this issue by developing two synthetic procedures for MSN size modulation, performed in homogenous aqueous/ethanol solution or two-phase aqueous/ethyl acetate system. Both approaches make use of tetraethyl orthosilicate as precursor, in the presence of cetyltrimethylammonium bromide, as structure-directing agent, and NaOH, as base-catalyst. NaOH catalyzed syntheses usually require high temperature (>80 °C) and large reaction medium volume to trigger MSN formation and limit aggregation. Here, a successful modulation of MSNs size from 40 up to 150 nm is demonstrated to be achieved by purposely balancing synthesis conditions, being able, in addition, to keep reaction temperature not higher than 50 °C (30 °C and 50 °C, respectively) and reaction mixture volume low. Through a comprehensive and in-depth systematic morphological and structural investigation, the mechanism and kinetics that sustain the control of MSNs size in such low dimensional regime are defined, highlighting that modulation of size and pores of the structures are mainly mediated by base concentration, reaction time and temperature and ageing, for the homogenous phase approach, and by temperature for the two-phase synthesis. Finally, an in vitro study is performed on bEnd.3 cells to investigate on the cytotoxicity of the MNSs. 相似文献
166.
Silvia Canepari Elisabetta Marconi Maria Luisa Astolfi Cinzia Perrino 《Analytical and bioanalytical chemistry》2010,397(6):2533-2542
A quick and reliable analytical method for the separation and quantification of extractable Sb(III) and Sb(V) in atmospheric
particulate matter (PM) by ion chromatography(IC)-inductively coupled plasma-mass spectrometry (ICP-MS) has been optimized,
validated on pairs of real, equivalent PM10 samples and applied to a field monitoring campaign in a urban site. Both Sb(III) and Sb(V) forms were detected in real samples
with Sb(III)/Sb(V) ratios up to 1.5. These two Sb species accounts only for a portion, of variable magnitude, of the total
extractable Sb (10–70%); anyway, no other soluble Sb species were detected in the samples. The analysis of size-segregated
samples collected by a 13-stage impactor showed that the recovery of [Sb(III) + Sb(V)] versus total extractable Sb is almost
quantitative in the coarse fraction while it is below than 10% in the fine fraction. In the extracted solution from particles
below 1 μm we could highlight the presence of Sb-containing suspended solid nano-particles, which probably constitute the
missing fraction. The contribution of nano-particles can be estimated as the difference between ICP-MS and IC-ICP-MS data,
as small size solid bodies are able to pass through the nebulizer and reach the plasma torch, while they are retained by the
chromatographic column. The aggregation state of these nano-particles seems to be easily altered when they are suspended in
a water solution; a similar behavior could be hypothesized when in contact with biological fluids. It has been confirmed that
brake pad abrasion is the prevalent source of Sb(III) in PM and that Sb(V) may be formed by oxidation during the braking processes.
Differing from other environmental matrices, there is no evidence of any spontaneous oxidative conversion within the two species. 相似文献
167.
Claudio Mele Sandra Rondinini Lucia D’Urzo Vincenzo Romanello Elisabetta Tondo Alessandro Minguzzi Alberto Vertova Benedetto Bozzini 《Journal of Solid State Electrochemistry》2009,13(10):1577-1584
Nucleation and growth of silver, electrodeposited from water–acetonitrile (CH3CN from 0 to 100% by volume) mixed solvents on glassy carbon electrodes, was studied by means of double-sweep voltammetry,
current–time transients (CTT) and scanning electron microscopy (SEM). The effects of the addition of the specifically interacting
tetrabuthylammonium cation were also investigated. From voltammetries, the formal potential, the nucleation potential and
the cathodic current efficiency have been evaluated as a function of the mixed solvent composition. The key role on nucleation
kinetics of transferring Ag+ from the bulk phase to the CH3CN-enriched electrode/solution interphase has been highlighted. CTT transients were described by a model combining instantaneous
and progressive nucleation mechanisms. SEM images highlighted the effects of the presence of the organic solvent, which yields
to a more regular growth, and of the quaternary ammonium salt, which exhibits grain-refining properties. 相似文献
168.
Comparison of detection limits, for two metallic matrices, of laser-induced breakdown spectroscopy in the single and double-pulse configurations 总被引:4,自引:0,他引:4
Ismail MA Cristoforetti G Legnaioli S Pardini L Palleschi V Salvetti A Tognoni E Harith MA 《Analytical and bioanalytical chemistry》2006,385(2):316-325
Limits of detection have been studied for several elements in aluminium and steel alloys, at atmospheric pressure in air,
by use of the single and collinear double-pulse configurations of laser-induced breakdown spectroscopy. For this purpose,
calibration plots were constructed for Mg, Al, Si, Ti, Cr, Mn, Fe, Ni, and Cu using a set of certified aluminium alloy samples
and a set of certified steel samples. The investigation included optimization of the experimental conditions to furnish the
best signal-to-noise ratio. Inter-pulse delay, gate width, and acquisition delay were studied. The detection limits for the
elements of interest were calculated under the optimum conditions for the double-pulse configuration and compared with those
obtained under the optimum conditions for single-pulse configuration. Significantly improved detection limits were achieved,
for all the elements investigated, and in both aluminium and steel, by use of the double-pulse configuration. The experimental
findings are discussed in terms of the measured plasma conditions (particle and electron density, and temperature). 相似文献
169.
Cabras T Inzitari R Fanali C Scarano E Patamia M Sanna MT Pisano E Giardina B Castagnola M Messana I 《Journal of separation science》2006,29(17):2600-2608
In the present study the analytical potential of HPLC-MS/MS was utilized for the structural characterization of a post-translational modification of statherin. Human salivary statherin (M(av)5380.0 +/- 0.3 Da) is transformed by the action of transglutaminase 2 into a cyclic derivative with an average molecular mass of 5363.0 +/- 0.3 Da. The intra-molecular bridge is generated by the loss of an ammonia molecule between the unique Ione-pair donating nucleophile Lys-6 and one acceptor among the seven glutamine residues of statherin. Digestion of the cyclic derivative with chymotrypsin, proteinase K, and carboxypeptidase Y, monitored by HPLC-electrospray ionization-ion trap-mass spectrometric analysis, demonstrated that cyclization involved almost specifically Gln-37 (> 95%), with the percentage of Gln-39 implicated in the cross-linkiing being less than 5%. The main derivative was named cyclostatherin Q37. Guineapig transglutaminase 2 showed high affinity for statherin in vitro (Km = 0.65 +/- 0.06 microM). Cyclo-statherin was detected in vivo by HPLC-electrospray ionization ion trap-mass spectrometry analysis of whole human saliva and it accounted for about 1% of total statherin. Detection of cyclo-statherin in whole saliva is suggestive of a putative role of this molecule in the formation of the "oral protein pellicle". 相似文献
170.
Claudia Bendazzoli Elisabetta Mileo Marco Lucarini Stefano Olmo Vanni Cavrini Roberto Gotti 《Mikrochimica acta》2010,169(1-2):23-31
The micellization of the ionic surfactant sodium dodecyl sulfate (SDS) has been investigated in the presence of neutral cyclodextrins by means of capillary electrophoresis (CE). The measurements of electric current allowed the determination of the critical micelle concentration of SDS in the presence of α-, β- and γ-cyclodextrin, and of (2-hydroxypropyl)-β-cyclodextrin and (2,6-di-O-methyl)-β-cyclodextrin. Measurements of the CE current also yields information on the binding of SDS by cyclodextrins. The results are supported by electronic paramagnetic resonance spectroscopy and suggest that the methylated cyclodextrin affects the micellization of SDS in an unconventional way compared to other considered cyclodextrins. The combination of SDS with methylated cyclodextrin can have a profound effect on the reliable application of cyclodextrin-modified micellar electrokinetic chromatography. 相似文献