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排序方式: 共有704条查询结果,搜索用时 15 毫秒
51.
We study a class of degenerate elliptic second order differential operators acting on some polynomial weighted function spaces on [0,+[. We show that these operators are the generators of C
0-semigroups of positive operators which, in turn, are the transition semigroups associated with right-continuous normal Markov processes with state space [0,+]. Approximation and qualitative properties of both the semigroups and the Markov processes are investigated as well. Most of the results of the paper depend on a representation of the semigroups we give in terms of powers of particular positive operators of discrete type we introduced and studied in a previous paper. 相似文献
52.
53.
In this paper we propose a continuous-time Markov chain to describe the spread of an infective and non-mortal disease into a community numerically limited and subjected to an external infection. We make a numerical simulation that shows tendencies for recurring epidemic outbreaks and for fade-out or extinction of the infection. 相似文献
54.
Elisabetta Brenna Claudio Fuganti Francesco G. Gatti Fabio Parmeggiani 《Tetrahedron: Asymmetry》2009,20(22):2594-2599
A new scaleable synthetic route to the title compounds has been developed. The reaction pathway is based on the α-chymotrypsin-catalysed hydrolysis of the racemic ethyl 2-ethoxy-3-(p-methoxyphenyl)propanoate or of the racemic ethyl 2-methoxy-3-(p-methoxyphenyl)propanoate to give the corresponding resolved (S)-esters with excellent ee. The acids were easily separated from the (S)-esters by a simple acid–base work-up. The overall yields of 1 and 2 were 16% and 17%, respectively. 相似文献
55.
Ohne Zusammenfassung 相似文献
56.
This paper is devoted to the analysis of a one-dimensional model for phase transition phenomena in thermoviscoelastic materials.
The corresponding parabolic-hyperbolic PDE system features a strongly nonlinear internal energy balance equation, governing the evolution of the absolute temperature ϑ, an evolution equation for the phase change parameter χ, including constraints on the phase variable, and a hyperbolic stress-strain relation for the displacement variable u. The main novelty of the model is that the equations for χ and u are coupled in such a way as to take into account the fact that the properties of the viscous and of the elastic parts influence
the phase transition phenomenon in different ways. However, this brings about an elliptic degeneracy in the equation for u which needs to be carefully handled.
First, we prove a global well-posedness result for the related initial-boundary value problem. Secondly, we address the long-time
behavior of the solutions in a simplified situation. We prove that the ω-limit set of the solution trajectories is nonempty, connected and compact in a suitable topology, and that its elements solve
the steady state system associated with the evolution problem.
Dedicated to Jürgen Sprekels on the occasion of his 60th birthday 相似文献
57.
Elisabetta Tornatore Stefania Maria Buccellato Pasquale Vetro 《Rendiconti del Circolo Matematico di Palermo》2006,55(2):223-240
We propose a stochastic disease model where vaccination is included and such that the immunity isn’t permanent. The existence,
uniqueness and positivity of the solution and the stability of disease free equilibrium is studied. The numerical simulation
is done. 相似文献
58.
Anna Luise Grab Dirk Hose Patrick Horn Elisabetta Ada Cavalcanti-Adam Anja Seckinger Martin Müller 《Particle & Particle Systems Characterization》2021,38(3):2000263
In the malignant plasma cell disease multiple myeloma (MM), bone lesions and resulting fractures caused by MM cell (MMC) accumulation represent a major cause of morbidity and mortality. Despite recent advantages in systemic treatment, residual MMCs remain, especially in bone lesions. Therefore an interfacial delivery system for local treatment of MM and induced bone disease based on polyelectrolyte complex nanoparticles (PEC NP) loaded with bone morphogenetic protein 6 (BMP-6) inducing de-novo bone formation and MMC apoptosis is presented herein. BMP-6 loaded PEC NP are fabricated by defined mixing bio-related cationic and anionic polysaccharides and BMP-6 according to molar ratio of BMP-6/PEC-NP of 1/3. BMP-6/PEC NP bound to a model substrate releases 10% BMP-6 sustainably within two weeks as accessed by infrared spectroscopy. BMP-6 loaded PEC NP adheres to cell membranes of MMCs and MSCs and activated phosphorylation of Smad 1/5. Osteogenic differentiation (ALP-concentration) is enhanced in MSCs (p < 0.05). All patient samples (10/10) of MMCs show significant induction of apoptosis (median 84%, p < 0.05). Finally, BMP-6/PEC NP are successfully integrated in a commercial hyaluronic acid based hydrogel material revealing MMC death as principal proof for the local treatment of MM induced bone lesions. 相似文献
59.
Tosi G Conti C Giorgini E Ferraris P Garavaglia MG Sabbatini S Staibano S Rubini C 《The Analyst》2010,135(12):3213-3219
Fourier transform infrared (FTIR) microspectroscopy has been employed to investigate benign (ordinary dermal and Reed nevi), dysplastic and malignant (invasive melanoma) skin lesions through the analysis of spectral changes of melanocytes as well as in the evaluation of the presence of melanin. Hierarchical cluster analysis and principal component analysis led to a satisfactory separation of malignant from dysplastic and normal melanocytes. Also, on enlarging the clustering with spectra from Reed and dermal nevi, the multivariate analysis segregated well the spectral data into discrete clusters, allowing the obtaining of reliable average spectra for analysis at the molecular level of the main groups or components responsible for the biological and biochemical changes. The most significant spectral characteristics appear to be related to differences in secondary protein structures, in nucleic acid conformation, in intra- and intermolecular bonding. In all cases, supervised and unsupervised spectral analyses resulted in satisfactory agreement with histopathological findings. 相似文献
60.
Elisabetta Maccaroni 《Journal of organometallic chemistry》2010,695(4):487-8610
Reduction of [NMe4]2[ReBr5(NO)] (1) with zinc in acetonitrile leads to the known trisacetonitrile compound [ReBr2(CH3CN)3(NO)] (2). Attempts to turn 2 into a dihydrogen or a hydride complex applying direct reaction with H2 or with H2 and a base were unsuccessful. Complex 2 could be transformed into [ReBr(BF4)mer-(CH3CN)3(NO)] (2a) with AgBF4 in acetonitrile and was used as a starting material in a ligand exchange reaction with the water soluble phosphine 1,3,5-triaza-7-phosphadamantane (PTA) to obtain the complex [ReBr2(NO)(PTA)3] (3). When the reduction of 1 with zinc was carried out in the presence of PTA in acetonitrile, the disubstituted complex [ReBr2(CH3CN)(NO)(PTA)2] (4) was formed. The olefin-coordinated rhenium complexes [ReBr2(NO)(CH2CH2)(PTA)2] (5a) and [ReBr2(NO)(PhCHCH2)(PTA)2] (5b) were obtained from the reaction of 4 with the corresponding olefins. Complex 4 reacts further with NaHBEt3 in THF to give the dihydride [ReH2(THF)(NO)(PTA)2] (6). In the presence of ethylene 6 is transformed into the ethyl hydride complex [ReH(CH2CH3)(η2-C2H4)(NO)(PTA)2] (7). Complexes 6 showed catalytic activity in the hydrogenation of olefins. 相似文献