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排序方式: 共有237条查询结果,搜索用时 15 毫秒
11.
Mia Kurek Nasreddine Benbettaieb Mario
etar Eliot Chaudy Maja Repaji Damir Klepac Sreko Vali Frdric Debeaufort Kata Gali 《Molecules (Basel, Switzerland)》2021,26(9)
Chitosan and pectin films were enriched with blackcurrant pomace powder (10 and 20% (w/w)), as bio-based material, to minimize food production losses and to increase the functional properties of produced films aimed at food coatings and wrappers. Water vapor permeability of active films increased up to 25%, moisture content for 27% in pectin-based ones, but water solubility was not significantly modified. Mechanical properties (tensile strength, elongation at break and Young’s modulus) were mainly decreased due to the residual insoluble particles present in blackcurrant waste. FTIR analysis showed no significant changes between the film samples. The degradation temperatures, determined by DSC, were reduced by 18 °C for chitosan-based samples and of 32 °C lower for the pectin-based samples with blackcurrant powder, indicating a disturbance in polymer stability. The antioxidant activity of active films was increased up to 30-fold. Lightness and redness of dry films significantly changed depending on the polymer type. Significant color changes, especially in chitosan film formulations, were observed after exposure to different pH buffers. This effect is further explored in formulations that were used as color change indicators for intelligent biopackaging. 相似文献
12.
With the continual pressure to ensure follow-up molecules to billion dollar blockbuster drugs, there is a hurdle in profitability and growth for pharmaceutical companies in the next decades. With each success and failure we increasingly appreciate that a key to the success of synthesized molecules through the research and development process is the possession of drug-like properties. These properties include an adequate bioactivity as well as adequate solubility, an ability to cross critical membranes (intestinal and sometimes blood-brain barrier), reasonable metabolic stability and of course safety in humans. Dependent on the therapeutic area being investigated it might also be desirable to avoid certain enzymes or transporters to circumvent potential drug-drug interactions. It may also be important to limit the induction of these same proteins that can result in further toxicities. We have clearly moved the assessment of in vitro absorption, distribution, metabolism, excretion and toxicity (ADME/TOX) parameters much earlier in the discovery organization than a decade ago with the inclusion of higher throughput systems. We are also now faced with huge amounts of ADME/TOX data for each molecule that need interpretation and also provide a valuable resource for generating predictive computational models for future drug discovery. The present review aims to show what tools exist today for visualizing and modeling ADME/TOX data, what tools need to be developed, and how both the present and future tools are valuable for virtual filtering using ADME/TOX and bioactivity properties in parallel as a viable addition to present practices. 相似文献
13.
P. Boulanger A. Heym J. -M. Mayor Z. A. Pietrzyk 《Zeitschrift für Angewandte Mathematik und Physik (ZAMP)》1973,24(3):439-442
A double discharge TEA CO2 laser of simple design has been tested. The linearly polarized beam delivers a total energy of 14 Joules in 25 ns. The influence of the different gas mixtures on the problem of arcing, delay between pumping and lasing, and evolution of the light pulse, has been investigated. Using 0.1% xylene in the gas mixture, 200 Joules per liter were fed in the glow discharge without arcing. The maximum efficiency is 6.5%.
Résumé Le comportement d'un laser CO2TEA à deux décharges est étudié. Il délivre des impulsions de lumière polarisée d'une énergie de 14 Joules et durant 25 ns. L'influence de la composition du mélange gazeux sur des phénomènes tels que l'arcage, le dálai entre le pompage et l'émission lumineuse ainsi que sur la forme de l'impulsion, a été étudiée. L'introduction de 0.1% de xylène dans le mélange gazeux a permis de dissiper une énergie de 200 Joules par litre de décharge sans produire d'arc. Le rendement maximum a été de 6.5%.相似文献
14.
Using a mathematical framework which provides a generalization of the de Rham complex (well-designed for p-form gauge fields), we have studied the gauge structure and duality properties of theories for free gauge fields transforming in arbitrary irreducible representations of GL(D, ). We have proven a generalization of the Poincaré lemma which enables us to solve the above-mentioned problems in a systematic and unified way. 相似文献
15.
Patricia Segonds Benoit Boulanger Bertrand Menaert Julien Zaccaro 《Research on Chemical Intermediates》2008,34(2-3):217-228
We report the sphere method as a unique characterization technique for the complete study of non-linear optical properties for frequency conversion in new materials belonging to the uniaxial or biaxial optical class. It relies on the use of a single crystal with millimetre dimensions cut as a sphere, combined with a tuneable laser source. With the sphere method we perform direct measurements of phase-matching angles and associated conversion efficiencies for second harmonic, sum- and difference-frequency generation. Furthermore, we follow the orientation of the dielectric frame as a function of the wavelength for monoclinic and triclinic crystals. It also allows the determination of the magnitude of the principal refractive indices in biaxial crystals based on the study of the double refraction affect at the exit of a sphere. By combining the analysis of all these data simultaneously, we determine Sellmeier equations reliable over the whole transparency domain and we are able to get the non-zero elements of the second-order susceptibility tensor of uniaxial or biaxial crystals. Finally, the sphere method is completely self-sufficient for the study of biaxial crystals. 相似文献
16.
The remarkable ability of nematic elastomers to exhibit large deformations under small applied forces is known as soft elasticity.
The recently proposed neo-classical free-energy density for nematic elastomers, derived by molecular-statistical arguments,
has been used to model soft elasticity. In particular, the neo-classical free-energy density allows for a continuous spectrum
of equilibria, which implies that deformations may occur in the complete absence of force and energy cost. Here we study the
notion of force-free states in the context of a continuum theory of nematic elastomers that allows for isotropy, uniaxiality,
and biaxiality of the polymer microstructure. Within that theory, the neo-classical free-energy density is an example of a
free-energy density function that depends on the deformation gradient only through a nonlinear strain measure associated with
the deformation of the polymer microstructure relative to the macroscopic continuum. Among the force-free states for a nematic
elastomer described by the neo-classical free energy density, there is, in particular, a continuous spectrum of states parameterized
by a pair of tensors that allows for soft deformations. In these force-free states the polymer microstructure is material
in the sense that it stretches and rotates with the macroscopic continuum. Limitations of and possible improvements upon the
neo-classical model are also discussed.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
17.
18.
Joan Boulanger Olivier Balima 《Journal of Quantitative Spectroscopy & Radiative Transfer》2011,112(7):1222-1228
We present the first reconstruction algorithm for refractive index imaging, which is based on the radiative transfer equation (RTE). An objective function is iteratively minimized to find a solution to the problem of inversion of the refractive index field. The function describes the discrepancies of the emerging light measurements on the surface of the sample to be probed with predicted data from the corresponding numerical model. The unknown refractive index field is updated within each reconstruction iteration according to a search direction on the index distribution given by the adjoint model to the RTE. In this paper, emphasis is placed on the theoretical aspects. Preliminary tests are demonstrated on generic phantoms. 相似文献
19.
Shi W Petersen EB Nguyen DT Yao Z Chavez-Pirson A Peyghambarian N Yu J 《Optics letters》2011,36(18):3575-3577
We report a unique all fiber-based single-frequency Q-switched laser in a monolithic master oscillator power amplifier configuration at ~1920 nm by using highly Tm-doped germanate fibers for the first time. The actively Q-switched fiber laser seed was achieved by using a piezo to press the fiber in the fiber Bragg grating cavity and modulate the fiber birefringence, enabling Q-switching with pulse width and repetition rate tunability. A single-mode polarization maintaining large core 25 μm highly Tm-doped germanate fiber was used in the power amplifier stage. For 80 ns pulses with 20 kHz repetition rate, we achieved 220 μJ pulse energy, which corresponds to a peak power of 2.75 kW with transform-limited linewidth. 相似文献
20.