A VERSATILE METHOD FOR THE CONVERSION OF ALDOXIMES TO NITRILES USING SILICA GEL/THIONYL CHLORIDE

A simple convenient procedure for dehydration of aldoximes has been developed using silica gel/thionyl chloride in heterogeneous conditions. The method has been found to be effective for a wide range of aromatic oximes.     

Thermal performance enhancement in a miniature channel using different passive methods

Journal of Thermal Analysis and Calorimetry - In the present work, different passive methods have been numerically investigated to improve the thermal performance in a miniature channel. The heat...     

The effect of basecoat pigmentation on mechanical properties of an automotive basecoat/clearcoat system during weathering

The aim of this study is to elucidate the effect of basecoat pigmentation on mechanical aspects of an automotive basecoat/clearcoat (BC/CC) system during artificial weathering exposures. A silver basecoat as the most reflective and a black basecoat as the most absorptive basecoat were selected. These two extreme behaviored basecoats were chosen with hopes that other basecoats would behave somewhere between the silver and the black extremes. The structural and mechanical properties of the coatings were investigated after various weathering exposure times (0, 150, 300, 450, 600 h). Dynamic mechanical thermal analysis (DMTA) was carried out to study variations in structure and basic characteristics of the system such as cross-linking density and T_g during weathering. In order to investigate variations in mechanical properties of the system, nano indentation, nano scratch, and tensile tests were also utilized.It was found that although both silver and black systems experienced post-curing reactions (dominant at earlier stages of weathering) and degradation reactions (dominant at later stages of weathering), but basecoat pigmentation affected the post-curing and degradation reaction rates of the BC/CC system, leading to variations in mechanical properties. It was concluded that post-curing occurred to a greater extent in the black pigmented system whilst in the silver pigmented system weathering degradation was much more sever.     

One-step Synthesis of 3,4-Dihydrobenzimidazo[2,1- b ]quinazolin-1(2 H )-ones in an Ionic Liquid

A novel class of 3,4-dihydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones was synthesized in very short reaction times with good yields in the presence of 3-butyl-1-methyl imidazolium bromide as a room temperature ionic liquid at 120°C. The ionic liquid can be recycled for subsequent reactions without any loss of efficiency.     

Tuning the electronic‐optical properties of porphyrin‐like porous C24N24 fullerene with (Li3O)n = (1–5) decoration. A computational study

Using DFT methods, the electronic properties and the first hyperpolarizabilities of porphyrin‐like porous C₂₄N₂₄ fullerene decorated with (Li₃O)_{n = (1–5)} have been systematically investigated. It is found that Li₃O molecules can effectively be adsorbed over N4 cavities of C₂₄N₂₄ with high interaction energies. This interaction is found to narrow the HOMO‐LUMO gap and work function values of C₂₄N₂₄. Thus its electronic properties are strongly sensitive to interaction with the Li₃O molecules. Indeed, compared with the sole parent C₂₄N₂₄ fullerene, (Li₃O)_{n = (1–5)}@C₂₄N₂₄ possess large first hyperpolarizabilities (β₀ ). Obviously, the Li₃O superalkali chemisorbed over C₂₄N₂₄ fullerene exhibit not only excellent stability but also large first hyperpolarizability. Therefore, they are expected to be potential innovative candidates for excellent electro‐optical materials.     

Design,synthesis, biological evaluation,and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase

A new series of acridine-9-carboxamide-1,2,3-triazole derivatives 7a-m were designed, synthesized, and evaluated as novel α-glucosidase inhibitors. Acridine-9-carboxamide-1,2,3-triazole scaffold has been designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds were more potent than standard inhibitor acarbose. Among the title compounds, the most potent compounds were compounds 7j , 7k , and 7a with IC₅₀ values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6 μM, respectively (IC₅₀ value of acarbose = 750.0 ± 10.0 μM). Docking study of the most potent compounds demonstrated that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds 7j , 7k , and 7a was performed and no activity was observed. in vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds 7j , 7k , and 7a were also performed.     

Erratum to: Top local cohomology modules and Gorenstein injectivity with respect to a semidualizing module

This note makes a correction to the paper “Top local cohomology modules and Gorenstein injectivity with respect to a semidualizing module”.