(R)-Spiro[(2R)-N-acetyl-2-phenyl-1,3-thiazolidine-4,3'-(3a'R,6a'S)-5',6a'-dimethyl-3a',-6a'-dihydro-3H-furo[2,3-b]furan-2-one]     

M. Ramos Silva  A. Matos Beja  J. A. Paixo  L. Alte da Veiga  D. M. Barbosa  M. I. L. Soares  T. M. V. D. Pinho e Melo  A. M. d'A. Rocha Gonsalves 《Acta Crystallographica. Section C, Structural Chemistry》1999,55(7):1094-1096

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3α-Hydroxy-5α-androstane-4,17-dione     

L. C. R. Andrade  J. A. Paixo  M. J. De Almeida  E. J. Tavares da Silva  M. L. S e Melo  A. S. Campos Neves 《Acta Crystallographica. Section C, Structural Chemistry》1999,55(12):2149-2151

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Elder Pacheco da Cruz;Felipe Nardo dos Santos;Jaqueline Ferreira de Souza;Estefania Júlia Dierings de Souza;Laura Martins Fonseca;André Ricardo Fajardo;Elessandra Rosa da Zavareze;Alvaro Renato Guerra Dias; 《先进技术聚合物》2024,35(6):e6479

Polymer concentration and aging time of polymeric solutions are crucial factors that can influence their viscosity, playing an essential role in the fabrication of electrospun nanofibers. Based on this, herein we evaluated the impact of aging time (24 and 48 h) and pea starch concentration (10%, 20%, and 30%, wt/vol) on the polymeric solutions to produce electrospun nanofibers. Solutions were evaluated by rheology, electrical conductivity, and degree of substitution. The nanofibers were analyzed by morphology, size distribution, chemical nature, and thermal properties. The degree of substitution of starches varied from 1.17 to 1.56. Overall, electrical conductivity decreased with increasing starch concentration and aging time of the polymeric solutions. The use of 10% starch displayed a transition from capsules to fibers, while 20% and 30% starch were able to manufacture homogenous, cylindrical, and random nanofibers with diameters varying from 89 to 373 nm. A significant impact of viscosity was not observed; on the other hand, aging time increased the average diameter of nanofibers. Besides, the fabricated nanofibers showed a lower decomposition temperature than raw starch. The fabricated nanofibers have great potential as wall materials for the encapsulation of different compounds and applications in the biomedical and food sectors.  相似文献   

    

Ana Ruas  Angelica Graa  Joana Marto  Lídia Gonalves  Ana Oliveira  Alexandra Nogueira da Silva  Madalena Pimentel  Artur Mendes Moura  Ana Teresa Serra  Ana Cristina Figueiredo  Helena M. Ribeiro 《Molecules (Basel, Switzerland)》2022,27(11)

Essential oils (EOs) and hydrolates (Hds) are natural sources of biologically active ingredients with broad applications in the cosmetic industry. In this study, nationally produced (mainland Portugal and Azores archipelago) EOs (11) and Hds (7) obtained from forest logging and thinning of Eucalyptus globulus, Pinus pinaster, Pinus pinea and Cryptomeria japonica, were chemically evaluated, and their bioactivity and sensorial properties were assessed. EOs and Hd volatiles (HdVs) were analyzed by GC-FID and GC-MS. 1,8-Cineole was dominant in E. globulus EOs and HdVs, and α- and β-pinene in P. pinaster EOs. Limonene and α-pinene led in P. pinea and C. japonica EOs, respectively. P. pinaster and C. japonica HVs were dominated by α-terpineol and terpinen-4-ol, respectively. The antioxidant activity was determined by DPPH, ORAC and ROS. C. japonica EO showed the highest antioxidant activity, whereas one of the E. globulus EOs showed the lowest. Antimicrobial activity results revealed different levels of efficacy for Eucalyptus and Pinus EOs while C. japonica EO showed no antimicrobial activity against the selected strains. The perception and applicability of emulsions with 0.5% of EOs were evaluated through an in vivo sensory study. C. japonica emulsion, which has a fresh and earthy odour, was chosen as the most pleasant fragrance (60%), followed by P. pinea emulsion (53%). In summary, some of the studied EOs and Hds showed antioxidant and antimicrobial activities and they are possible candidates to address the consumers demand for more sustainable and responsibly sourced ingredients.  相似文献   

    

Thierry Wesley de Albuquerque Aguiar  Jos Josenildo Batista  Silvio Assis de Oliveira Ferreira  Maíra de Vasconcelos Lima Sampaio  Dewson Rocha Pereira  Magda Rhayanny Assuno Ferreira  Luiz Alberto Lira Soares  Ana Maria Mendona de Albuquerque Melo  Mnica Camelo Pessoa de Azevedo Albuquerque  Andr de Lima Aires  Hallysson Douglas Andrade de Araújo  Luana Cassandra Breitenbach Barroso Coelho 《Molecules (Basel, Switzerland)》2022,27(15)

Biomphalaria glabrata snails constitute the main vector of schistosomiasis in Brazil, and Bauhinia monandra Kurz, the leaves of which contain BmoLL lectin with biocidal action, is a plant widely found on continents in which the disease is endemic. This work describes the composition of B. monandra preparations and the effect on embryos and adult snails, their reproduction parameters and hemocytes. We also describe the results of a comet assay after B. glabrata exposure to sublethal concentrations of the preparations. Additionally, the effects of the preparations on S. mansoni cercariae and environmental monitoring with Artemia salina are described. In the chemical evaluation, cinnamic, flavonoid and saponin derivatives were detected in the two preparations assessed, namely the saline extract and the fraction. Both preparations were toxic to embryos in the blastula, gastrula, trochophore, veliger and hippo stages (LC₅₀ of 0.042 and 0.0478; 0.0417 and 0.0419; 0.0897 and 0.1582; 0.3734 and 0.0974; 0.397 and 0.0970 mg/mL, respectively) and to adult snails (LC₅₀ of 6.6 and 0.87 mg/mL, respectively), which were reproductively affected with decreased egg deposition. In blood cell analysis, characteristic cells for apoptosis, micronucleus and binucleation were detected, while for comet analysis, different degrees of nuclear damage were detected. The fraction was able to cause total mortality of the cercariae and did not present environmental toxicity. Therefore, B. monandra preparations are promising in combating schistosomiasis since they can control both the intermediate host and eliminate the infectious agent, besides being safe to the environment.  相似文献   

    

Ana Valria de Oliveira Braz  Mariana Carvalho Rodrigues  Philippe Alencar Araújo Maia  Ana Paula Dantas Pereira  Jussara de Lima Silva  Francisco Antonio Vieira dos Santos  Luiz Everson da Silva  Wanderley do Amaral  Maura Lins dos Santos  Henrique Douglas Melo Coutinho  Tomasz Baj  Grayna Kowalska  Rados&#x;aw Kowalski  Edinardo Fagner Ferreira Matias 《Molecules (Basel, Switzerland)》2022,27(18)

Commercialized mouthwashes are generally expensive for the most financially vulnerable populations. Thus, several studies evaluate the antimicrobial potential of herbal products, such as essential oils, to reduce the activity of microorganisms in the mouth. The objective of this research was to carry out the chemical characterization and antibacterial activity of the essential oil of Piper mosenii (EOPm), providing data that enable the development of a low-cost mouthwash formulation aimed at vulnerable communities. The analysis of the antibacterial potential and modulator of bacterial resistance was verified by the microdilution method to determine the minimum inhibitory concentration-MIC. The chemical components were characterized by gas chromatography coupled to mass spectrometry, where 23 chemical constituents were detected, with α-pinene, being the major compound. The EOPm showed a MIC ≥ 1024 µg/mL for all bacterial strains used in the tests. When the EOPm modulating activity was evaluated together with chlorhexidine, mouthwash and antibiotics against bacterial resistance, the oil showed a significant synergistic effect, reducing the MIC of the products tested in combination, in percentages between 20.6% to 96.3%. Therefore, it is recommended to expand the tests with greater variation of EOPm concentration and the products used in this research, in addition to the evaluation of toxicity and in vivo tests, seeking the development of a possible formulation of mouthwash accessible to the vulnerable population.  相似文献   

    

Francisco W. Maciel-Silva  Daniel Lachos-Perez  Luz Selene Buller  William G. Sganzerla  Montserrat Prez  Mauricio A. Rostagno  Tania Forster-Carneiro 《Molecules (Basel, Switzerland)》2022,27(19)

The detection of analytes in complex organic matrices requires a series of analytical steps to obtain a reliable analysis. Sample preparation can be the most time-consuming, prolonged, and error-prone step, reducing the reliability of the investigation. This review aims to discuss the advantages and limitations of extracting bioactive compounds, sample preparation techniques, automation, and coupling with on-line detection. This review also evaluates all publications on this topic through a longitudinal bibliometric analysis, applying statistical and mathematical methods to analyze the trends, perspectives, and hot topics of this research area. Furthermore, state-of-the-art green extraction techniques for complex samples from vegetable matrices coupled with analysis systems are presented. Among the extraction techniques for liquid samples, solid-phase extraction was the most common for combined systems in the scientific literature. In contrast, for on-line extraction systems applied for solid samples, supercritical fluid extraction, ultrasound-assisted extraction, microwave-assisted extraction, and pressurized liquid extraction were the most frequent green extraction techniques.  相似文献   

    

Renata Quartieri Nascimento  Cludio Vaz Di Mambro Ribeiro  Nelson Barros Colauto  Larissa da Silva  Paulo Vitor Frana Lemos  Ederlan de Souza Ferreira  Giani Andrea Linde  Bruna Aparecida Souza Machado  Pedro Paulo Lordelo Guimares Tavares  Aline Camaro Telles Biasoto  Marcelo Andres Umsza Guez  Natlia Carvalho  Denílson de Jesus Assis  Jania Betnia Alves da Silva  Carolina Oliveira de Souza 《Molecules (Basel, Switzerland)》2022,27(20)

Edible insects are a potential alternative food source of high feed conversion efficiency and protein content. Zophobas atratus is an edible insect that adapts to different diets, enabling sustainable rearing by adding value to by-products and agro-industrial residues. This study aimed to evaluate the performance and nutritional characterization of Zophobas atratus larvae fed with different proportions of grape residue. Physicochemical analysis of the diets and larvae (AOAC procedures), fatty acid profile (chromatographic techniques), metals and non-metals (inductively coupled plasma optical emission spectrometry), larval mass gain, feed conversion efficiency, and mortality rate were assessed. The replacement of 25% of the conventional diet with grape residue increased lipid, ash, and fiber contents and reduced protein, carbohydrates, and energy. It promoted greater mass gain, lower mortality rate, and reduced larval growth time by 51%. Among the replacements, 25% resulted in the second-highest content of calcium, sodium, magnesium, and zinc, and the lowest content of potassium and phosphorus in the larvae. The 100% replacement resulted in the highest amounts of C18:2n6 (27.8%), C18:3n3 (2.2%), and PUFA (30.0%). Replacing 25% of the conventional diet with grape residue is equivalent to the conventional diet in many aspects and improves several larvae performance indices and nutritional values.  相似文献   

    

Amanda Rodrigues Pinto Costa  Marcelly Muxfeldt  Fernanda da Costa Santos Boechat  Maria Cecília Bastos Vieira de Souza  Jerson Lima Silva  Marcela Cristina de Moraes  Luciana Pereira Rangel  Tuane Cristine Ramos Gonalves Vieira  Pedro Netto Batalha 《Molecules (Basel, Switzerland)》2022,27(22)

Prion Diseases or Transmissible Spongiform Encephalopathies are neurodegenerative conditions associated with a long incubation period and progressive clinical evolution, leading to death. Their pathogenesis is characterized by conformational changes of the cellular prion protein—PrP^C—in its infectious isoform—PrP^Sc—which can form polymeric aggregates that precipitate in brain tissues. Currently, there are no effective treatments for these diseases. The 2,5-diamino-1,4-benzoquinone structure is associated with an anti-prion profile and, considering the biodynamic properties associated with 4-quinolones, in this work, 6-amino-4-quinolones derivatives and their respective benzoquinone dimeric hybrids were synthesized and had their bioactive profile evaluated through their ability to prevent prion conversion. Two hybrids, namely, 2,5-dichloro-3,6-bis((3-carboxy-1-pentyl-4-quinolone-6-yl)amino)-1,4-benzoquinone (8e) and 2,5-dichloro-3,6-bis((1-benzyl-3-carboxy-4-quinolone-6-yl)amino)-1,4-benzoquinone (8f), stood out for their prion conversion inhibition ability, affecting the fibrillation process in both the kinetics—with a shortening of the lag phase—and thermodynamics and their ability to inhibit the formation of protein aggregates without significant cytotoxicity at ten micromolar.  相似文献   

    

Steffi I. Macías  Guillem Ruano  Núria Borràs  Carlos Alemán  Elaine Armelin 《Journal of polymer science. Part A, Polymer chemistry》2022,60(4):688-700

Among additive manufacturing, photocuring 3D printing technologies are very relevant because of its high printing speed and high precision. However, the limited performance of photosensitive thermoset polymers is the bottleneck for the application of photocuring 3D printing in some fields, particularly in the biomedical sector. Thus, the development of biodegradable and biocompatible materials is highly desirable and of utmost importance. In this work, a biodegradable and non-cytotoxic thermoset polymer for photocuring 3D printing is reported. It consists of an unsaturated polyesteramide bearing phenylalanine, 2-butene-1,4-diol and fumarate building blocks, which is photocured under UV irradiation using a low molecular weight poly(ethylene glycol) diacrylate as crosslinker. The main characteristics of the new thermoset are: (1) very high volumetric and mechanical integrity stabilities, comparable to that of photocured epoxides; (2) very high degradation temperature; (3) very low water absorption capacity; (4) relatively fast enzymatic degradation, reaching 16.5% after 3 months; and (5) non-cytotoxic response in presence of epithelial cells, even when soluble molecular fragments coming from biodegradation are considered. These properties favor the future utilization of the new polyether-polyesteramide resin in the manufacturing of more sustainable products via 3D printing methods, such as stereolithography, that uses UV sources.  相似文献