Solvent-Free Microwave-Assisted Organic Reactions Preparation of β-Keto Esters

Microwave technique has been utilised in the preparation of β-keto esters. Two different procedures are described: transesterification of β-keto esters and ring opening of 2,2,6-trimethyl-1,3-dioxin-4-one.     

A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice

Alcohol use disorder (AUD) affects over 18 million people in the US. Unfortunately, pharmacotherapies available for AUD have limited clinical success and are under prescribed. Previously, we established that avermectin compounds (ivermectin [IVM] and moxidectin) reduce alcohol (ethanol/EtOH) consumption in mice, but these effects are limited by P-glycoprotein (Pgp/ABCB1) efflux. The current study tested the hypothesis that dihydromyricetin (DHM), a natural product suggested to inhibit Pgp, will enhance IVM potency as measured by changes in EtOH consumption. Using a within-subjects study design and two-bottle choice study, we tested the combination of DHM (10 mg/kg; i.p.) and IVM (0.5–2.5 mg/kg; i.p.) on EtOH intake and preference in male and female C57BL/6J mice. We also conducted molecular modeling studies of DHM with the nucleotide-binding domain of human Pgp that identified key binding residues associated with Pgp inhibition. We found that DHM increased the potency of IVM in reducing EtOH consumption, resulting in significant effects at the 1.0 mg/kg dose. This combination supports our hypothesis that inhibiting Pgp improves the potency of IVM in reducing EtOH consumption. Collectively, we demonstrate the feasibility of this novel combinatorial approach in reducing EtOH consumption and illustrate the utility of DHM in a novel combinatorial approach.     

Organisational linkages and O.R. projects

An empirical study of a group of O.R. projects in presented with particular attention being paid to organisational interactions. The results are derived from detailed investigations of O.R. projects in which both the managers(s) and O.R. practitioner(s) were interviewed. This initial exploration has indicated a variety of organisational forms, and revealed the importance of non-formal processes that often take place.     

Classification and identification of recorded and synthesized impact sounds by practiced listeners, musicians, and nonmusicians

Three experiments were conducted to test the viability of a low-parameter modal model for synthesizing impact sounds to be used in commercial and psychoacoustic research. The model was constrained to have four physically based parameters dictating the amplitude, frequency, and decay of modes. The values of these parameters were selected by ear to roughly match the recordings of ten different resonant objects suspended by hand and struck with different mallets. In experiment 1, neither 35 professional musicians nor 187 college undergraduates could identify which of the two matched sounds was the real recording with better than chance accuracy, though significantly better than chance performance was obtained when modal parameters were selected without the previously imposed physical constraints. In experiment 2, the undergraduates identified the source corresponding to the recorded and synthesized sounds with the same level of accuracy and largely the same pattern of errors. Finally, experiment 3 showed highly practiced listeners to be largely insensitive to changes in the acoustic waveform resulting from an increase in the number of free parameters used in the modal model beyond 3. The results suggest that low-parameter, modal models might be exploited meaningfully in many commercial and research applications involving human perception of impact sounds.     

Multiaxial deformation of polyethylene and polyethylene/clay nanocomposites: in situ synchrotron small angle and wide angle X‐ray scattering study

A unique in situ multiaxial deformation device has been designed and built specifically for simultaneous synchrotron small angle X‐ray scattering (SAXS) and wide angle X‐ray scattering (WAXS) measurements. SAXS and WAXS patterns of high‐density polyethylene (HDPE) and HDPE/clay nanocomposites were measured in real time during in situ multiaxial deformation at room temperature and at 55 °C. It was observed that the morphological evolution of polyethylene is affected by the existence of clay platelets as well as the deformation temperature and strain rate. Martensitic transformation of orthorhombic into monoclinic crystal phases was observed under strain in HDPE, which is delayed and hindered in the presence of clay nanoplatelets. From the SAXS measurements, it was observed that the thickness of the interlamellar amorphous region increased with increasing strain, which is due to elongation of the amorphous chains. The increase in amorphous layer thickness is slightly higher for the nanocomposites compared to the neat polymer. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011     

Zur elektrolytischen Bestimmung der Salpeters?ure

Ohne Zusammenfassung     

Mixed convection boundary-layer flow over a vertical surface embedded in a porous medium

In this paper we have numerically investigated the existence and uniqueness of a vertically flowing fluid passed a model of a thin vertical fin in a saturated porous media. We have assumed the two-dimensional mixed convection from a fin, which is modelled as a fixed, semi-infinite vertical surface, embedded in a fluid-saturated porous media under the boundary-layer approximation. We have taken the temperature, in excess of the constant temperature in the ambient fluid on the fin, to vary as  , where is measured from the leading edge of the plate and λ is a fixed constant. The Rayleigh number is assumed to be large so that the boundary-layer approximation may be made and the fluid velocity at the edge of the boundary-layer is assumed to vary as . The problem then depends on two parameters, namely λ and , the ratio of the Rayleigh to Péclet numbers. It is found that when λ>0 (<0) there are (is) dual (unique) solution(s) when is grater than some negative values of (which depends on λ). When λ<0 there is a range of negative value of (which depends on λ) for which dual solutions exist and for both λ>0 and λ<0 there is a negative value of (which depends on λ) for which there is no solution. Finally, solutions for 0<1 and 1 have been obtained.