Quantitative assessment of the degree of hoarseness

By using a computer simulation, the author examined the theoretically expected discrepancy of the obtained H/N ratio from the real H/N value, the effects of perturbatios of pitch, and amplitude on the H/N ratio and others. Regarding the averaged wave as an estimate of the harmonic component, resulted in harmonic energy greater than its real value. The H/N ratio method detected perturbations of pitch and amplitude as a quantity of noise energy. The effect of pitch perturbation on the H/N ratio was much greater than that of amplitude perturbation. The error range of the measurement system did not contribute significantly to the calculated H/N ratios.     

Singular surfaces in a linear thermo-elastic dielectric material

Singular surfaces in a linear thermo-elastic dielectric material are considered, where the constitutive equations of the elastic dielectric proposed by Toupin and the heat equations with finite wave velocities are combined. There exist six types of singular surfaces including a stationary one. The velocities, the coupled fields and the variation of the amplitudes of the surfaces with respect to time are investigated. It is found that the amplitude of the mechanical transverse wave rotates during propagation and at the stationary surface the amplitude of the electric field periodically reverses in direction and the one of the polarization field rotates elliptically with the same period.     

Glucuronide conjugation of phenols in isolated rabbit hepatocytes measured by high-pressure liquid chromatography

Summary High-pressure liquid chromatography has been applied for the assay of reactants of UDP-glucuronyltransferase from isolated hepatocytes with different phenols. The substrate donor molecule UDP-glucuronic acid, its primary product of hydrolysis UMP, the products of glucuronidation -glucuronide and UDP, and the substrate can be assayed in a single run. The method is based on ion-pair chromatography and may be extended for the study of various pathways in the biotransformation of drugs and other endogenous and exogenous phenolic toxins.     

Enantio- and diastereomerically pure threo-homoallylic alcohols via highly stereoselective reduction of α-methyl-β,γ-unsaturated ketones

Reduction of α-methyl-β,γ-unsaturated ketones with L-Selectride proceeded with high $\text{threo}$-selectivity to afford $\text{threo}$-β-methyl homoallylic alcohols of high enantio- and diastereomerical purities.     

Abnormal osmium tetroxide oxidation of N-methylmorphinan derivatives

3-Methoxy-N-methylmorphinan and 3-methoxy-N-methylisomorphinan reacted with osmium tetroxide to give the N-formyl compound and 15,16-dioxo-N-methyl derivative. The structure of these compounds was confirmed by chemical and physical methods.