全文获取类型
收费全文 | 1072篇 |
免费 | 14篇 |
国内免费 | 1篇 |
专业分类
化学 | 678篇 |
晶体学 | 13篇 |
力学 | 54篇 |
数学 | 37篇 |
物理学 | 305篇 |
出版年
2021年 | 10篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 5篇 |
2017年 | 10篇 |
2016年 | 15篇 |
2015年 | 11篇 |
2014年 | 17篇 |
2013年 | 60篇 |
2012年 | 50篇 |
2011年 | 49篇 |
2010年 | 36篇 |
2009年 | 30篇 |
2008年 | 45篇 |
2007年 | 39篇 |
2006年 | 46篇 |
2005年 | 37篇 |
2004年 | 45篇 |
2003年 | 46篇 |
2002年 | 35篇 |
2001年 | 28篇 |
2000年 | 27篇 |
1999年 | 21篇 |
1998年 | 11篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 16篇 |
1994年 | 18篇 |
1993年 | 26篇 |
1992年 | 25篇 |
1991年 | 23篇 |
1990年 | 17篇 |
1989年 | 16篇 |
1988年 | 19篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 18篇 |
1984年 | 32篇 |
1983年 | 12篇 |
1982年 | 17篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1979年 | 9篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 9篇 |
1973年 | 7篇 |
1970年 | 4篇 |
排序方式: 共有1087条查询结果,搜索用时 15 毫秒
1.
T. Nakayama T. Tanaka Y. Tsumoto H. Katayama M. Katto 《Applied Physics A: Materials Science & Processing》2004,79(4-6):833-836
A new method for high-quality hydroxyapatite (HAp) coating is developed, the laser-assisted laser ablation method. In this method, two lasers are used. One is used for ablation of a HAp target. The other, the assist laser, is used to irradiate a Ti substrate surface. The effects of the assist laser irradiation are to anneal the HAp coating and to improve its adhesive strength to the Ti substrate. The quality of the HAp coating depends on the delay time of the assist-laser irradiation. HAp coatings obtained at a delay time of 10 microseconds or more are more amorphous. It was confirmed that the amorphous part of a coating dissolves in simulated body fluid, while the crystalline part does not. The value of the Ca/P ratio in a coating obtained at a delay time of a few microseconds is close to the stoichiometric value. PACS 81.16.Mk 相似文献
2.
T Kai T Isami K Kobata Y Kurosaki T Nakayama T Kimura 《Chemical & pharmaceutical bulletin》1992,40(9):2498-2504
The maximum fluxes (Jmax) of beta-blockers through keratinized membranes were determined in vitro and compared with their physiochemical parameters such as lipophilicity (log k'0) and melting point (mp). Rat abdominal skin and hamster cheek pouch mucosa were used as the model membranes. Propranolol, metoprolol, timolol, pindolol, nadolol and agenolol were used as beta-blockers with a variety of physicochemical characters. Linear relations of Jmax with either log k'0 or mp were observed both in intact rat skin and in intact hamster cheek pouch, suggesting that the lipophilicity and thermodynamic activity of a drug in the crystal state primarily affect the drug's permeation through these membranes. However, the slope, dJmax/d(log k'0), for cheek pouch mucosa was greater than that for rat skin, corresponding to the lack of appendigeal shunt pathways in cheek pouch. Penetration studies using the delipidized membranes and the isolated stratum corneum sheet of hamster cheek pouch mucosa clarified that the primary rate-limiting barrier function might exist in the lipid layer of the stratum corneum. Jmax values for the tape-stripped and delipidized skins correlated with both the solubilities of drugs in the vehicle and with the mp, suggesting the polar porous characteristics of both model membranes. However, a theoretical approach confirmed that the contribution of an intracellular or aqueous pore route in the intact membrane to the permeation of drugs with positive lipophilic indexes is negligible. 相似文献
3.
4.
5.
6.
The treatment of tert-alkyl phenyl thioketones with Lawesson’s reagent (LR) gave two diastereomeric 1,3,2-dithiaphosphetane 2-sulfides in high yields. The structure of one of the major diastereomers was determined by X-ray crystallography. The reaction of 2-adamantanethione with LR yielded the corresponding spiro-1,3,2-dithiaphosphetane 2-sulfide derivative in 87% yield. 相似文献
7.
8.
Sachiko Yamada Keiko Nakayama Hiroaki Takayama Toshimasa Shinki Tatsuo Suda 《Tetrahedron letters》1984,25(30):3239-3242
(25)-25,26-Dihydroxy-23-oxovitamin D3 was synthesized efficiently and stereoselectively, and it was converted enzymatically to (25)-1α,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of 1α,25-dihydroxyvitamin D3. The spectral and chemical properties of (25)-25,26-dihydroxy-23-oxovitamin D3 and its 1α,hydroxylated derivative disagree with those reported for the isolated metabolite. 相似文献
9.
10.
Properties and efficacies of novel aldose reductase (AR) inhibitors, M16209 (1-(3-bromobenzo[b]furan-2-ylsulfonyl)hydantoin) and M16287 (1-(3-chlorobenzo[b]furan-2-ylsulfonyl)hydantoin), were examined in vitro and in vivo, compared with known AR inhibitors, ONO-2235 and sorbinil. These four compounds inhibited partially purified aldose reductases from various origins, and the potencies of M16209 and M16287 were on the whole similar to ONO-2235, and were greater than that of sorbinil. The IC50 values of the four AR inhibitors did not substantially depend on the substrate used. Kinetic studies of inhibition of partially purified bovine lens (BLAR) revealed that M16209, M16287 and sorbinil were uncompetitive with glyceraldehyde and noncompetitive with nicotineamide adenine dinucleotide phosphate (NADPH), whereas ONO-2235 was noncompetitive with both glyceraldehyde and NADPH. Aldose reductase became less sensitive to the four inhibitors as enzyme purification progressed, although the susceptibility to inhibition was partially reversed by incubation with dithiothreitol. In addition, the four compounds slightly affected those enzymes of carbohydrate and glutathione metabolism which were tested. M16209 and M16287 prevented sorbitol accumulation in isolated rat tissues as potently as ONO-2235 and sorbinil. M16209 and M16287 were effective in the prevention of galactosemic cataracts and amelioration of diabetic neuropathy with almost the same potency, while ONO-2235 was effective only in neuropathy, and sorbinil was effective in galactosemic cataracts and diabetic neuropathy with a different potency. These results indicate that M16209 and M16287 are potent aldose reductase inhibitors, which could be applicable to treatment for diabetic complications. 相似文献