Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water‐soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water‐solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.
A novel, fast and convenient method for the bromination of thiophenes and oligothiophenes with N-bromosuccinimide (NBS) using ultrasonic irradiation is elaborated. The yield of bromothiophenes strongly depends on the initial thiophene structure and nature of the solvent. 相似文献
The EtOAc, n-BuOH and H20 subextracts of the crude MeOH extract of the aerial parts of Sedum caespitosum (cav.) Dc. were screened for cytotoxicity using the neutral red assay in Chinese hamster ovary cells as well as their protective effect against H2O2 induced cytotoxicity in human red blood cells. While the extracts did not show cytotoxicity, they displayed a protective effect compared to a blank and ascorbic acid. Gallic acid (1), kaempferol 3-O-alpha-rhamnopyranoside (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-alpha-rhamnopyranoside (4) and myricetin 3-O-alpha-rhamnopyranoside (5) were isolated from the EtOAc extract and identified by 1D- and 2D-NMR. The protective effects of the isolated compounds against H2O2 induced cytotoxicity in human red blood cells were evaluated and 5 was the most active. 相似文献
Two poly(Schiff base)s (PDBT and PDPE) were synthesized by polycondensation of 1,10-phenanthroline-5,6- dione (PD) with 2,2′-diamino-4,4′-bithiazole (DABT) and 4,4′-diaminodiphenyl ether (DAPE),respectively.The structures of the polymers were determined by FTIR and element analysis.The metal (Fe~(2+),Ni~(2+)) complexes were prepared from the polymers with FeSO_4 or NiSO_4,and the metal contents of the complexes were measured by complexometric titration.The magnetic behaviors of the complexes were examine... 相似文献
A catalytic method was developed to synthesize substituted phenols from the corresponding aryl bromides and chlorides under mild conditions (yields = 34–92%). 4-Methoxylbenzyl alcohol was used as water surrogate and CuI/3,4,7,8-tetramethyl-1,10-phenanthroline was used as catalyst to achieve the C–O cross-coupling. 相似文献
Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus,their structures were identified as daphneolone(1),S-(+)-1-(4-hydroxy-3-methoxyphenyl)-3-hydroxy-5-phenyl-1-pentanone(2),S-(+)-1-(4-methoxyphenyl)-3- hydroxy-5-phenyl-1-pentanone(3),and among them,2 was a new compound,3 was a novel natural product. 相似文献
Natural phycobilisomes(PBSs) were isolated and purified from a red macroalga,Polysiphonia urceolata,by multi-step of sucrose gradient centrifugation,and were chemically stabilized by small molecule cross-linker formaldehyde.The stabilized PBSs showed similar absorption and fluorescent properties at room temperature compared to natural PBSs and kept a steady F672/F580 value during more than 3 months of storage in 0.45 mol/L phosphate buffer(pH 6.8) or at low temperature at 77 K.The stabilized PBS migrated... 相似文献
Magnetic-field modulation of delayed fluorescence from poly(2-vinylnaphthalen) in a low-temperature glass at 77 K is reported. The observations are interpreted in terms of local ordering of the naphthalene chromophores with their normal axes aligned approximately parallel to one another. 相似文献