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131.
Antoni SánchezSonia Recillas Xavier FontEudald Casals Edgar GonzálezVíctor Puntes 《Trends in analytical chemistry : TRAC》2011,30(3):507-516
This article presents recent developments on the use of inorganic nanoparticles (NPs) for environmental remediation in polluted soil, water and gas. The number of publications on these topics has grown exponentially in recent years, especially those focused on wastewater treatment. Among these topics, removal of metals has become the most popular, although some works relate to the use of nanomaterials for the elimination of nutrients (e.g., nitrogen and some persistent organic pollutants). However, this growth has not been accompanied by knowledge about the behavior of NPs once used and released into the environment. In this article, we also comment upon the current situation with respect to NP toxicology (nanotoxicology). A remarkable number of different toxicology tests has been applied to NPs, often making it very difficult to interpret or to generalize the results. We analyze in detail the bioluminescence, Daphnia magna and other tests, and give some preliminary results obtained in our work. 相似文献
132.
A sensitive procedure is presented for the voltammetric determination of nickel. The procedure involves an adsorptive accumulation of nickel 1-nitroso-2-napthol (NN) complex on a bismuth film electrode prepared ex situ by electrodeposition. The most suitable operating conditions and parameters such as pH, ligand concentration (CNN), adsorptive potential (Eads), adsorptive time (tads), scan rate and others were selected and the determination of nickel in aqueous solutions using the standard addition method was possible. The adsorbed Ni-NN complex gives a well defined cathodic stripping peak current at −0.70 V, which was used for the determination of nickel in the concentration range of 10.0-70.0 μg L−1 (pH 7.5; CNN 6.5 μmol L−1; Eads −0.30 V; tads 60 s) with a detection limit of 0.1 μg L−1. The relative standard deviation for a solution containing 10.0 μg L−1 of Ni(II) was 3.5% (n = 4). The proposed method was validated determining Ni(II) in certified reference waste water (SPS-WW1) and Certified Reference Water for Trace Elements (TMDA 51.3) with satisfactory results. Then lake water samples were analyzed. 相似文献
133.
Albrow VE Ponder EL Fasci D Békés M Deu E Salvesen GS Bogyo M 《Chemistry & biology》2011,18(6):722-732
Sentrin specific proteases (SENPs) are responsible for activating and deconjugating SUMO (Small Ubiquitin like MOdifier) from target proteins. It remains difficult to study this posttranslational modification due to the lack of reagents that can be used to block the removal of SUMO from substrates. Here, we describe the identification of small molecule SENP inhibitors and active site probes containing aza-epoxide and acyloxymethyl ketone (AOMK) reactive groups. Both classes of compounds are effective inhibitors of hSENPs 1, 2, 5, and 7 while only the AOMKs efficiently inhibit hSENP6. Unlike previous reported peptide vinyl sulfones, these compounds covalently labeled the active site cysteine of multiple recombinantly expressed SENP proteases and the AOMK probe showed selective labeling of these SENPs when added to complex protein mixtures. The AOMK compound therefore represents promising new reagents to study the process of SUMO deconjugation. 相似文献
134.
Haim?KaplanEmail author Edgar?Ramos Micha?Sharir 《Discrete and Computational Geometry》2011,45(1):3-33
In approximate halfspace range counting, one is given a set P of n points in ℝ
d
, and an ε>0, and the goal is to preprocess P into a data structure which can answer efficiently queries of the form: Given a halfspace h, compute an estimate N such that (1−ε)|P∩h|≤N≤(1+ε)|P∩h|. 相似文献
135.
Berthe J Garcia JM Ocando E Kato T Saffon-Merceron N De Cózar A Cossío FP Baceiredo A 《Journal of the American Chemical Society》2011,133(40):15930-15933
The synthesis of the first isolable C-phosphino-Ge-aminogermyne, stabilized by a phosphine ligand, has been achieved. X-ray diffraction analysis indicates a quite long Ge-C bond whose length is between that of a single and a double bond but consistent with the theoretically predicted values for a germyne bearing π-donating substituents. The isomerization of this germyne derivative affords a new stable N-heterocyclic germylene through migration of the original phosphine ligand from germanium to the carbon center. 相似文献
136.
Linden AH Lange S Franks WT Akbey U Specker E van Rossum BJ Oschkinat H 《Journal of the American Chemical Society》2011,133(48):19266-19269
Methods enabling structural studies of membrane-integrated receptor systems without the necessity of purification provide an attractive perspective in membrane protein structural and molecular biology. This has become feasible in principle since the advent of dynamic nuclear polarization (DNP) magic-angle-spinning NMR spectroscopy, which delivers the required sensitivity. In this pilot study, we observed well-resolved solid-state NMR spectra of extensively (13)C-labeled neurotoxin II bound to the nicotinic acetylcholine receptor (nAChR) in native membranes. We show that TOTAPOL, a biradical required for DNP, is localized at membrane and protein surfaces. The concentration of active, membrane-attached biradical decreases with time, probably because of reactive components of the membrane preparation. An optimal distribution of active biradical has strong effects on the NMR data. The presence of inactive TOTAPOL in membrane-proximal situations but active biradical in the surrounding water/glycerol "glass" leads to well-resolved spectra, yet a considerable enhancement (ε = 12) is observed. The resulting spectra of a protein ligand bound to its receptor are paving the way for further DNP investigations of proteins embedded in native membrane patches. 相似文献
137.
Gaidzik N Kaiser A Kowalczyk D Westerlind U Gerlitzki B Sinn HP Schmitt E Kunz H 《Angewandte Chemie (International ed. in English)》2011,50(42):9977-9981
A shot in the arm for cancer treatment: Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages. 相似文献
138.
We study attracting graphs of step skew products from the topological and ergodic points of view where the usual contracting-like assumptions of the fiber dynamics are replaced by weaker merely topological conditions. In this context, we prove the existence of an attracting invariant graph and study its topological properties. We prove the existence of globally attracting measures and we show that (in some specific cases) the rate of convergence to these measures is exponential.
相似文献139.
140.
Jonathan P Wisor Bruce F O'Hara Akira Terao Chris P Selby Thomas S Kilduff Aziz Sancar Dale M Edgar Paul Franken 《BMC neuroscience》2002,3(1):20-14