Development and Evaluation of Europium-Based Quantitative Lateral Flow Immunoassay for the Chronic Kidney Disease Marker Cystatin-C

Journal of Fluorescence - This study aimed to establish a Europium label time-resolved fluorescence immunoassay (TRFIA) to detect the chronic kidney disease (CKD) biomarker Cystatin-C. An Europium...     

Investigation of angucycline compounds as potential drug candidates against SARS Cov-2 main protease using docking and molecular dynamic approaches

Molecular Diversity - The emerged Coronavirus disease (COVID-19) causes severe or even fatal respiratory tract infection, and to date there is no FDA-approved therapeutics or effective treatment...     

Optical and electrical properties of modulation-doped n and p-type Ga x In1-x N y As1-y /GaAs quantum wells for 1.3 μm laser applications

We present a comprehensive study of spectral photoluminescence (PL), photoconductivity and Hall mobility in undoped, n and p-type modulation-doped quantum wells of Ga_1-x In _x N _y As_1-y /GaAs with varying nitrogen concentration. We show that the increasing nitrogen composition red shifts the energy gap and this red shift is accompanied with a reduction of the 2D electron mobility in the quantum wells. True temperature dependence of the band gap, free from errors associated with nitrogen induced exciton trapping effects, is observed because in the modulation doped QW samples PL emission is dominated by band-to-band recombination and the S-shape temperature dependence is eliminated. Excellent fit to semi-experimental Varshni equation is obtained and the temperature dependence of the band gap in the linear regime (dE/dT) is tabulated as a function of nitrogen concentration and the type of dopant.     

Simultaneous quantification of six phenylethanoid glycosides in some Turkish Scutellaria species by a new HPLC-DAD method

A new HPLC-DAD method was developed and validated for simultaneous determination of six main phenylethanoid glycosides (calceolarioside D, neocalceolarioside D, verbascoside, isoverbascoside, leucoseptoside A and martynoside) in the aerial parts of four Scutellaria L. taxa from flora of Turkey. All standard compounds showed a good linearity (R ² > 0.999) in a relatively wide concentration range (1–120 μg/mL). The LOD of the compounds was in the range of 0.104–1.295 μg/mL and the LOQ was in the range of 0.450–2.536 μg/mL. The recoveries of the selected compounds were calculated in the range of 97.46–117.85%. The amounts of the phenylethanoid glycosides showed variation in the extracts. The developed method was found to be accurate, precise and reproducible, and successfully applied to identify and quantify the phenylethanoid glycoside composition of Scutellaria species.     

Simultaneous determination of levodopa and benserazide using poly(3-methylthiophene) and a multi-walled carbon nanotube sensor

Journal of Solid State Electrochemistry - Rapid, reliable, reproducible, and repeatable modified sensor designs have been developed to distinguish the binary mixture of levodopa and benserazide in...     

Non-abelian local reciprocity law

Following our work on the generalized Fesenko reciprocity map, we construct the non-abelian local reciprocity map ${\pmb{\Phi}_K^{(\varphi)}}$ of a local field K as a certain isomorphism from the absolute Galois group G _K of K onto a topological group ${\nabla_{K,Y}^{(\varphi)}}$ whose definition involves Fontaine–Wintenberger theory of field of norms, and build the non-abelian local class field theory over K in the sense of Fesenko and Koch.     

Analyzing the harmonic wave propagation in the layered thick tubes

In this study, the propagation of time harmonic waves in prestressed, anisotropic elastic tubes filled with viscous fluid is studied. The fluid is assumed to be incompressible and Newtonian. A two layered hyperelastic anisotropic structural model is used for the compliant arterial wall. The tube is subjected to a static inner pressure P_i and an axial stretch λ. The governing differential equations of tube are obtained in cylindrical coordinates, utilizing the theory of “Superposing small deformations on large initial static deformations”. The analytical solutions of the equations of motion for the fluid have been obtained. Due to variability of the coefficients of the resulting equations for the solid body they are solved numerically. The dispersion relation is obtained as a function of the stretch and material parameters.     

Effect of the surfactant alkyl chain length on the stabilisation of lyotropic nematic phases

Lyotropic quaternary mixtures of potassium alkanoates (KCx) and sodium alkyl sulphates (NaCxS), where x is the number of carbon atoms in their alkyl chains, were prepared to investigate the effect of the surfactant alkyl chain length on the stabilisation of lyotropic nematic phases. The lyotropic mixtures investigated were formed by the dissolution of KCx (NaCxS) surfactants in the mixture of Rb₂SO₄/1-decanol/water (Na₂SO₄/1-decanol/water), separately. The uniaxial-to-biaxial nematic phase transitions were identified from the temperature dependence of the birefringences of the nematic phases by means of laser conoscopy. The micelle dimensions were obtained from small-angle X-ray scattering measurements. It was observed that the increase in the surfactant alkyl chain length causes the micellar growth in the plane perpendicular to the main amphiphile bilayer. The surfactant alkyl chain length plays a key role on the shape anisotropy of micelles, which triggers the orientational fluctuations that are responsible for the stabilisation of the different lyotropic nematic phases.     

Application of stripping voltammetry method for the analysis of available copper,zinc and manganese contents in soil samples

Determination of copper (Cu), zinc (Zn) and manganese (Mn) micronutrients in soil samples have been studied for an efficient fertiliser application. Plant-available micronutrients of soils were extracted with DTPA extraction procedure, then differential pulse stripping voltammetry (DPSV) and square wave stripping voltammetry (SWSV) methods were performed with inexpensive and disposable pencil graphite electrode for determination of Cu(II), Zn(II) and Mn(II). Parameters such as deposition potential, deposition time, pH and concentration of the supporting electrolyte were optimised for these ions. Under optimised conditions, the limits of detection were found as 0.01 mg L^?1 for Cu(II) and 0.02 mg L^?1 for Zn(II) and 0.25 mg L^?1 for Mn(II). Relative standard deviation (%RSD) was 6.80, 8.86 and 3.29 for Cu(II), Zn(II) and Mn(II), respectively. The experimental study was conducted using a flame atomic absorption spectroscopy. The described stripping voltammetry methods were successfully applied for the determination of Mn(II), Cu(II) and Zn(II) in soil samples.