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31.
Hargreaves A Taiwo FA Duggan O Kirk SH Ahmad SI 《Journal of photochemistry and photobiology. B, Biology》2007,89(2-3):110-116
Ultraviolet A (UVA) light (315-400 nm) is ubiquitously found in our environment and constitutes about 95% of the total solar UV; all UVC and most UVB being absorbed by the stratospheric ozone layer. Compared with UVB and C, UVA does not show any direct effect on biological systems. Indirect effects of UVA, however, have been recognised overwhelmingly and this includes photosensitization of biological and non-biological compounds and production of free radicals many of which include oxygen and are hence known as reactive oxygen species or ROS. Several types of free radicals have been identified although their impacts on various macro- and micro-biomolecules are yet to be fully elucidated. beta-Phenylpyruvic acid is ubiquitously found in eukaryotic cells as a metabolite of phenylalanine, which is subsequently converted to phenyllactate and/or to 2-hydroxyphenylacetate and mandelate. In patients suffering from phenylketonuria the hydroxylation of phenylalanine to tyrosine is defective due to lack of phenylalanine hydroxylase. These result in accumulation and excretion of this compound in the urine. Here we present evidence that photolysis of beta-phenylpyruvic acid by a skin tanning lamp, emitting 99% UVA (315-400 nm) and 1% UVB (290-315 nm) generates carboxyl radicals (CO(2)(*)) and also possibly causes direct electron transfer (or type 1) reactions. Electron paramagnetic resonance was used to detect the free radicals. To determine the biological effects of this photolytic reaction, T7 was exposed to these photolytic reactive agents and found to lead to high levels of phage inactivation. Damage to DNA and/or components such as tail fibre proteins may be involved in T7 inactivation. In addition, our unpublished data suggest that certain phenylketonuria cell lines are more sensitive to PPA+NUV, lending importance to photolytic studies of this agent. 相似文献
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An alpha counting system has been designed which gives counting geometry of nearly 4π with resolution capabilities of 25 keV
or better. The alpha source is electro-deposited onto a thin gold foil which is sandwiched between two silicon surface barrier
detectors. Alpha pulses from the two detectors are amplified, normalized and summed as a single pulse height spectrum. The
techniques for the electrodeposition of the alpha activity onto the thin gold foil are described. 相似文献
35.
The synthesis sugar-transport properties of a family of five cavitand rim-appended boronic acids are reported. These conformationally rigid compounds are not observed to leach out of lipophilic membranes, and they exhibit unprecedented fructose to glucose transport selectivities and give higher fluxes than other neutral boronic acids. These properties make the cavitand boronic acids the best artificial fructose transporters described thus far. [structure: see text] 相似文献
36.
A novel synthesis of the title compound, involving the resolution of a Mannichbase derived from racemic 11,11-o-phenylenedioxy-7-hydroxy-1-dodecen-3-one is described. In an alternate approach 2(S)-acetamido-6,6-o-phenylenedioxy-heptanoic acid was used as the optically active starting material. This scheme features the preparation of a chiral 1,2-epoxide and its regiospecific alkylation with lithio-1, 1-diethoxy-2-propyne. 相似文献
37.
The preparation and characterization by LCMS of a library of 55 fluorescence- quenched peptides is described. The peptides bear a terminal anthranilamide fluorophore and a penultimate 2,4-dinitrophenyl-L-lysine quencher, and will be used to probe the substrate binding domain of the human blood coagulation enzyme, factor Xa. 相似文献
38.
F. D. McDaniel S. Matteson D. L. Weathers J. L. Duggan D. K. Marble I. Hassan Z. Y. Zhao J. M. Anthony 《Journal of Radioanalytical and Nuclear Chemistry》1992,160(1):119-140
Accelerator Mass Spectcrometry (AMS) is being used for both radionuclide dating and stable isotope trace element determination with limits of high sensitivity. The areas of applications of radionuclide AMS include oceanography, terrestrial studies, glaciology, hydrology, environmental studies, meteorology, archaeology, anthropology, analysis of crude oils, biomedical and materials sciences, etc. The techniques and applications of radionuclide AMS are reviewed. The applications of stable element AMS include the measurements of trace impurities in electronic and other materials. The techniques and applications of stable element AMS are discussed with particular emphasis on electronic materials such as Si, GaAs, and HgCdTe. The design of the University of North Texas stable element AMS facility built in collaboration with Texas Instruments Incorporated is discussed.Work supported in part by the National Science Foundation Grants No. DMR-8812331 and ECD-9003099, the Office of Naval Research Grants No. N00014-89-J-1309, N00014-89-J-1344, N00014-90-J-1691, and N00014-91-J-1785, Texas Instruments Incorporated, Texas Utilities Electric Inc. International Digital Modeling Corp., North Texas Research Institute, Combustion Engineering Inc., LTV Corporation, the State of Texas Higher Education Coordinating Board — Texas Advanced Technology Research Program, the Robert A. Welch Foundation, and the University of North Texas Organized Research Fund. 相似文献
39.
We have designed and synthesized a highly lipophilic boronic acid (11) with a molecular shape that makes it much more effective at carrying sugars through organic membranes than a previously used steroidal boronic acid. The corresponding diboronic acid (12) was also found to transport fructose ahead of glucose with a very high selectivity (7.6:1.0). Modeling suggests that 12 is able to carry two fructose molecules at once in a complex stabilized through hydrogen bonding and ion pairing. 相似文献
40.