Polarographische Bestimmung des Pyridoxols in pharmazeutischen Präparaten

Zusammenfassung Es wird eine neue polarographische Methode zur direkten Bestimmung des Pyridoxols in Injektionspräparaten und Tabletten beschrieben. Die ausgearbeitete Methode beruht auf der polarographischen Reduktion des Pyridoxolmoleküls im Milieu von Ammoniak-Ammoniumchlorid-Puffern und weiter auf der Bildung einer katalytischen Stufe des Pyridoxols in Veronalpuffern. Die polarographische Methode ist rascher und in manchen Fällen genauer und empfindlicher als die bisher in Gebrauch stehenden Methoden. Die Anwesenheit der in den Präparaten laufend vorkommenden Begleitstoffe des Pyridoxols stört nicht die polarographische Bestimmung. Die Methode kann auch zur Bestimmung des 3-Hydroxy-4-methoxymethyl-5-oxymethyl-2-methylpyridins benutzt werden, das ein Zwischenprodukt bei der Pyridoxolerzeugung ist.

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Summary A new polarographic method is described for the direct determination of pyridoxol in injection preparations and tablets. This method is based on the polarographic reduction of the pyridoxol in ammonia-ammonium chloride buffer medium and also on the formation of a catalytic stage of the pyridoxol in veronal buffers. The polarographic method is faster and in many cases more accurate and more sensitive than the methods now in use. The presence of the materials which always accompany the pyridoxol in the preparations does not interfere with the polarographic determination. The method can likewise be used for determining 3-hydroxy-4-methoxymethyl-5-oxymethyl-2-methylpyridine, which is an intermediate product in the manufacture of pyridoxol.

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Résumé On décrit une nouvelle méthode polarographique pour le dosage direct du pyridoxol dans les préparations pour injections et dans les comprimés. La méthode élaborée repose sur la réduction polarographique de la molécule de pyridoxol dans le milieu tampon ammoniaque-chlorure d'ammonium, et, en outre, sur la formation d'une phase catalytique du pyridoxol dans les tampons au véronal. La méthode polarographique est plus rapide et dans de nombreux cas plus exacte et plus sensible que les méthodes utilisées jusqu'ici. La présence d'impuretés existant couramment dans les préparations à côté du pyridoxol ne gêne pas le dosage polarographique. On peut aussi utiliser la méthode pour le dosage de l'hydroxy-3 méthoxyméthyl-4 oxyméthyl-5 méthyl-2 pyridine, substance intermédiaire dans la préparation du pyridoxol.

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Herrn Dr.P. Zuman danken wit für Ratsehläge bei der Abfassung dieser Arbeit.     

On Fractional Evolution Inclusion Coupled with a Time and State Dependent Maximal Monotone Operator

Set-Valued and Variational Analysis - The paper deals with second-order evolution problems driven by time and state dependent maximal monotone operators with non-Lipschitz perturbations. Systems...     

Neue Näherungsgleichung zur einheitlichen Berechnung von Wärmeübertragern

Zusammenfassung Es wird eine für alle Stromführungen einheitliche Näherungsgleichung mit drei oder vier anpaßbaren Parametern zur Berechnung des Korrekturfaktors für die mittlere logarithmische Temperaturdifferenz angegeben. Die anpaßbaren Parameter wurden für etwa 50 verschiedene Stromführungen durch Ausgleichsrechnung bestimmt. Die Genauigkeit der Gleichung ist für die Berechnung im praktisch wichtigen Bereich mehr als ausreichend.

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New approximate equation for uniform heat exchanger design

An approximate equation with three or four empirical parameters for the uniform calculation of the LMTD-correction factor of all heat exchanger configurations is proposed. The empirical parameters have been determined for about 50 different flow configurations using least squares estimation. The accuracy of the equation is more than sufficient for practical design purposes.

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Formelzeichen A Übertragungsfläche - a, b, c, d Parameter der Näherungsgleichung - Wärmekapazitätsstrom - F Korrekturfaktor für die logarithmische mittlere Temperaturdifferenz - k Wärmedurchgangskoeffizient - m, n Zahl der Durchgänge oder Einzelapparate - NTU Anzahl der Übertragungseinheiten (number of transfer units); NTU_i=kA/ _i - P dimensionslose Temperaturänderung - R Wärmekapazitätsstromverhältnis;R ₁=₁/₂;R ₂=₂/₁ - relativer Fehler - Mittelwert von NTU₁ und NTU₂ Indizes 1, 2 Stoffstrom 1, 2 - G Gegenstrom - s Schätzwert Herrn Prof. Dr.-Ing. E.h. K. Stephan zum 65. Geburtstag gewidmet.     

Tight upper bounds for the discrepancy of half-spaces

We show that the discrepancy of anyn-point setP in the Euclideand-space with respect to half-spaces is bounded byC _d n ^1/2−1/2d , that is, a mapping χ:P→{−1,1} exists such that, for any half-space γ, γ, |Σ _p∈P⋂γ χ(p)|≤C _d n ^1/2-1/2d . In fact, the result holds for arbitrary set systems as long as theprimal shatter function isO(m ^d ). This matches known lower bounds, improving previous upper bounds by a factor. Part of this research was done at the Third Israeli Computational Geometry Workshop in Ramot and during a visit at Tel Aviv University in December 1993. Also supported in part by Charles University Grant No. 351 and Czech Republic Grant GAČR 201/93/2167.     

On the support of the Ashtekar-Lewandowski measure

We show that the Ashtekar-Isham extension of the configuration space of Yang-Mills theories is (topologically and measure-theoretically) the projective limit of a family of finite dimensional spaces associated with arbitrary finite lattices.These results are then used to prove that is contained in a zero measure subset of with respect to the diffeomorphism invariant Ashtekar-Lewandowski measure on . Much as in scalar field theory, this implies that states in the quantum theory associated with this measure can be realized as functions on the extended configuration space .     

Kneser-type oscillation criteria for self-adjoint two-term differential equations

It is proved that the even-order equationy ⁽²ⁿ⁾ +p(t)y=0 is (n,n) oscillatory at if

Phase uniqueness and correlation length in diluted-field Ising models

The diluted-field Ising model, a random nonnegative field ferromagnetic model, is shown to have a unique Gibbs measure with probability I when the field mean is positive. Our methods involve comparisons with ordinary uniform field Ising models. They yield as a corollary a way of obtaining spontaneous magnetization through the application of a vanishing random magnetic field. The correlation lengths of this model defined as (lim _n-(1/n) log ₀; _n)^-1, wheren is the site on the first coordinate axis at distancen from the origin and ₀; _n is the origin ton two-point truncated correlation function, is non-random. We derive an upper bound for it in terms of the correlation length of an ordinary nonrandom model with uniform field related to the field distribution of the diluted model.     

Encapsulation of magnetite in vesicles

The encapsulation of fine magnetite particles of 10 nm size and marker ANS within asolectin vesicles has been made by sonication of the mixture in water. For the proof of encapsulation of magnetite in vesicles the electron microscope and spectrofluoriphotometer technique were used. The theory for the calculation of the magnetic force acting on the system consisted of non-capsulated magnetic particles dispersed in water and magnetic vesicles was developed.This work was supported by the Slovak Academy of Sciences within the framework of Project GAV No. 1361.     

Effect of nuclear structure on the single particle β− transitions in deformed nuclei

In the framework of the Nilsson model the calculations of the so called shape factor for the first forbidden ^– transitions 5/2^{+ 241}Pu 5/2^{– 241}Am and 7/2^{+ 177}Lu 7/2^{– 177}Hf are carried out. The dependence on the Nilsson potential parameters is studied. It turns out that for the transitions considered the calculated shape factor depends linearly on the electron energy and its slope is 10^–3 per 20 keV. This can affect the analysis of electron spectra if the endpoint energy is sufficiently large.