Eine Topologie auf der Menge der endlichdimensionalen nichtassoziativen Algebren über einem lokalen Körper

Motivated by an investigation ofKuz'min [2], in this note we introduce a topology on the set of nonassociative algebras of a fixed dimensionr< over a local fieldF. We obtain a space, which is notT ₁. If the trivial algebra is removed, the remaining subspace is quasicompact. The space is homeomoprhic to the group of square classes ofF ^*; forr3 the space is notT ₁. The set of division algebras is open in.     

Maße für gerichtete Geraden und nicht-symmetrische Pseudometriken in der Ebene II

We continue our investigations started in a paper with the same title. The -length of a curve defined in this paper can be written as an integral along the curve. Furthermore, we determine necessary and sufficient conditions for the existence of a measure of orientated lines which generates a given non-symmetric pseudo-metric.

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Herrn Prof. Dr. H.-J. Kanold zum 65. Geburtstag gewidmet     

Ein asymptotischer Ausdruck für eine zahlentheoretische Funktion

Arithmetic formulae and an asymptotic expression for the order of magnitude of the arithmetic function ged (s, n) and of a generalisation of it are derived.     

LP-Abschätzungen und klassische Lösungen für nichtlineare Wellengleichungen II

This paper deals with the global classical solvability of the Cauchy problem for nonlinear wave equations of higher order of the following form where denotes the Laplacian, a real constant, m a positive integer, and f the nonlinearity. Using results of the first part [6] concerning estimations for the kernel of the associated integral equation a priori estimates for certain L^P-norms of the local regular solution are established for higher space dimensions and for a class of nonlinearities satisfying certain growth and positivity conditions. This leads to completely regular solutions by means of the Sobolev embedding theorems.     

Der quadratfreie Kern der Eulerschen φ-Funktion

It is shown by a simple induction that any square-free natural number is the square-free kernel of Euler's -function of infinitely many natural numbers. Furthermore every square-free natural number >1 is the square-free kernel of Euler's -function of infinitely many square-numbers.     

Striktionseigenschaften von Regelscharen imE n

Let ={e(u)|uI} be a one-parameter family of straight lines forming a ruledC ^r-2-surface E ⁿ (n2,r1) without singular generatorse(u) (uI). As a synopsis, a generalization and an improvement of various results already known about the strictional properties of ruled surfaces E ⁿ (especially in the casen=3) the author demonstrates a uniform geometrical way of defining and uniquely obtaining thestriction point S(u) and theparameter of distribution d(u) of a generatore(u) under the minimal assumptions thate(u)E ⁿ (n2) be noncylindrical andr1. Other methods of obtainingS(u) andd(u) are discussed in comparison, and special strictional properties ofskew ruled surfaces E ⁿ are proved.

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Herrn Prof. Dr. H. R. Müller zum 65. Geburtstag     

A variational proof of the Gauss-Bonnet formula

The classical Gauss-Bonnet formula has the form I(g_ij)=2, where I(g_ij) represents a sum of three terms each of which depends on the metric tensor g_ij. It is shown that the first variation I of I(g_ij) with respect to the metric g_ij vanishes and that for the Euclidean metric _ij we have I(_ij)=2. From this the formula I(g_ij)=2 follows. In the process, explicit expressions are obtained for the first variation of each of the three terms which comprise I(g_ij). Furthermore, a general expression for the first variation of a multiple integral whose integrand is a scalar density depending on the metric tensor g_ij and its derivatives up to the second order is obtained with the aid of results of Rund [1].     

Mean value estimates in lattice point theory

LetQ(u) be a positive definite quadratic form inr2 variables with a real symmetric coefficient matrix of determinantD. Given a real vectorb with 0b _j <1, forx>0 letA(x) be the number of lattice points in the ellipsoidQ(u+b)x, letV(x) be the volume of this ellipsoid andP(x)=A(x)–V(x). Let . By introduction of a parameter we shall show how the treatment of estimates onP(x) and onM(x) can be unified.     

Lexicographic quasiconcave multiobjective programming

Summary Letf _i :A R ben real-valued objective functions on a convex setA -K ^m ,K:=R orC, n, mN. Letg: A R ⁿ be defined by , where for eachxA, (i ₁ (x), ..., i _n (x)) is a permutation of (1, ...,n) such that . In this paper we treat the problem of findingx ^*A such that , wherel-max denotes the lexicographic maximum. If the f_i's are strongly quasiconcave we can reduce the problem stepwise until finally it is in the form of a scalar programming problem. Further, we consider conditions for the existence and uniqueness of a solution and discuss the relationship of the problem to the vector maximum (i.e. Pareto) and maxmin (i.e. Chebychev) problems.

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Zusammenfassung f _i :AR seienn reellwertige Zielfunktionen über einer konvexen MengeA-K ^m ,K:=R oderC, n, mN. g:AR ⁿ sei definiert durch , wobei für jedesxA (i ₁ (x), ... i _n (x)) eine Permutation von (1, ...,n) derart ist, daß Wir betrachten das Problem, einx ^*A so zu finden, daß , wobeil-max das lexikographische Maximum bedeute. Falls dief _i stark quasikonkav sind, läßt sich das Problem stufenweise reduzieren, bis es schließlich die Gestalt eines skalaren Optimierungsproblems annimmt. Wir geben Existenz- und Eindeutigkeitsbedingungen an und besprechen Zusammenhänge mit dem Vektormaximumproblem (d.h. Pareto-Optimierung) und dem Maxmin-Problem (d.h. Tschebyscheff-Optimierung).

     

Structure activity relationship by NMR and by computer: a comparative study

There has recently been considerable interest in using NMR spectroscopy to identify ligand binding sites of macromolecules. In particular, a modular approach has been put forward by Fesik et al. (Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science 1996, 274, 1531-1534) in which small ligands that bind to a particular target are identified in a first round of screening and subsequently linked together to form ligands of higher affinity. Similar strategies have also been proposed for in silico drug design, where the binding sites of small chemical groups are identified, and complete ligands are subsequently assembled from different groups that have favorable interactions with the macromolecular target. In this paper, we compare experimental and computational results on a selected target (FKBP12). The binding sites of three small ligands ((2S)1-acetylprolinemethylester, 1-formylpiperidine, 1-piperidinecarboxamide) in FKBP12 were identified independently by NMR and by computational methods. The subsequent comparison of the experimental and computational data showed that the computational method identified and ranked favorably ligand positions that satisfy the experimental NOE constraints.