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991.
Using high‐resolution transmission electronic micrograph (HR‐TEM) observation, one can clearly see the pore geometry of the MCM‐41 and SBA‐15 mesoporous silicas to determine that their pore shapes are hexagonal and round, respectively. With the perpendicular orientations of the nanochannels to the electron beam, parallel line images of the (100) and (110) repeating spacings were observed. In the SBA‐15 mesoporous silicas, there are byproducts of the granular silica and disordered mesostructures, attributed to the weak hydrogen interactions between Pluronic 123 blockcopolymer and the silica species. There are also many different and significant +π disclination defects in SBA‐15 and MCM‐41 surfactant‐silica composites. The SBA‐15 with a thicker silica wall is more stable under irradiation by high‐energy electron beams compared to MCM‐41, which has thinner wall thickness. Some carbon nanostructure impurities were found in some carbon films on the metal grids. 相似文献
992.
Yasser M. Loksha Per T. Jrgensen Erik B. Pedersen Mahmoud A. El‐Badawi Ahmed A. El‐Barbary Claus Nielsen 《Journal of heterocyclic chemistry》2002,39(2):375-382
5‐Alkyl‐4‐benzyl‐1,3‐dihydroimidazol‐2‐ones ( 3a‐d ) and 5‐alkyl‐4‐benzyl‐1,3‐dihydroimidazole‐2‐thiones (7a‐d) were prepared via Dakin West reaction on DL‐phenylalanine with the appropriate aliphatic acid anhydrides followed by hydrolysis and reaction with potassium cyanate or potassium thiocyanate. Compounds 3a‐d were alkylated with ethoxymethyl chloride to give the alkylated imidazoles 5a‐d which were considered analogues of Emivirine with deletion of carbonyl group at the 4‐position. Alkylation of 7a‐d afforded the corresponding S‐alkylated derivatives 8a‐p which in a similar way were considered analogues of S‐DABO. However all the imidazole derivatives were devoid of activity against HIV. 相似文献
993.
Preparation and physical and chemical properties of 3-ethinyl-2,4-diformyl-pentandial (3 a) and its salts are described.3 a contains 2 malonaldehyde groups. Starting from3 a, 4H-pyranes, 4H-dihydropyridines, dipyrazoles, diisoxazoles, bisdiazepines and vinamidine derivates are obtained.
Mit 1 Abbildung 相似文献
Mit 1 Abbildung 相似文献
994.
K. Schweiger A. Fuchsgruber Prof. Dr. G. Zigeuner 《Monatshefte für Chemie / Chemical Monthly》1977,108(1):243-255
Tetrahydro-6-hydroxy-trimethyl-1,3-thiazine-2-thione (1) reacts with secondary amines via the dialkylammonium-3-oxoalkyldithiocarbamate3, either via isothiocyanates6 to 4-dialkylaminodihydro-2(1H)-pyridinethiones7 or to dialkylammonium dithiocarbamates (13), depending on the amine used and the reaction conditions. Subsequently, 6-dialkylaminotetrahydro-1,3-thiazine-2-thiones11 or tetrahydro-6-mercapto-1,3-thiazine-2-thione10 are formed. On being heated to reflux,11 reacts to pyridinethione7 and 4-dialkylaminodihydrothiopyranthione19. With secondary amines only13 is formed from tetrahydro-6-hydroxytetramethyl-1,3-thiazine-2-thione20. The reaction of dihydrotrimethyl-1,3-thiazine-2-thione21 with secondary amines leads to N,N-dialkylthioureas16 or dialkylammonium thiocyanates17 and with dialkylformamides 4-dialkylaminodihydropyridinethiones7 are formed. Dihydrotetramethyl-1,3-thiazine-2-thione24 reacts neither with secondary amines nor with dialkylformamides. 相似文献
995.
Dr. Mamdouh S. Masoud T. M. Salem M. Elessawi 《Monatshefte für Chemie / Chemical Monthly》1978,109(1):221-227
The reactions of the bidentate dinitrosoresorcinol (DNR) with copper, cobalt, nickel, iron and zinc salts were investigated. This ligand was found to react with these metal salts in aqueous media where hydrogen ion was confirmed to be liberated except in case of iron. The solid complexes were prepared in alcoholic media. Chemical analyses, magnetic and spectral data were compatible to determine the structure of these complexes and their mode of chelation.
Mit 2 Abbildungen 相似文献
Mit 2 Abbildungen 相似文献
996.
Prof. Dr. Heinz Falk Alfred Leodolter Georg Schade 《Monatshefte für Chemie / Chemical Monthly》1978,109(1):183-192
The electrochemical oxidation of arylmethylene-pyrrolinones, pyrromethenones and pyrromethenes as representative bile pigment partial structure models was investigated by means of a rotating disc platinum electrode using acetonitrile as the solvent. Two different oxidation reactions were found. The first reaction being a reversible one-electron oxidation with compounds of the arylmethylene-pyrrolinone series and pyrromethenones which are unsubstituted in position 5 of the pyrrole ring. A two step reaction (the first one reversible, the second irreversible) on the other hand was found to be typical for pyrromethenones bearing a methyl group in this position.Through protonation the first step is at a higher potential, whereas the second one is lowered and becomes reversible. The resulting oxidation pattern can be interpreted analogous to the oxidation of hydroquinones in aprotic solvents.The geometrical isomers of a pyrromethenone were oxidized at appr. the same potential, but there is a strong dependence of the potential of the first oxidation step on the substitution: a higher degree of alkylation favours oxidation by lowering the oxidation potential.
Mit 1 Abbildung 相似文献
Mit 1 Abbildung 相似文献
997.
The conversion of phosphoenolpyruvate (PEP) to phosphonopyruvate (P-pyr) is catalyzed by PEP mutase via a dissociative mechanism. In this work, we investigate the uncatalyzed reaction using ab initio methods, density functional theory, and the semiempirical MNDO/d method. Comparisons of geometries and relative energies of stationary points (minima and transition states) with density functional results indicate that the semiempirical method is reasonably accurate. Solvent effects are examined using implicit solvent models, including the recently extended smooth conductor-like screening model. Due to the large negative charge carried by the system, solvation is found to drastically alter the location and energy of stationary points along the dissociative reaction pathways. The influence of substituting a nonbridging phosphoryl oxygen by sulfur (thio effects) was also investigated. Implications of these results for the enzymatic reaction are discussed. 相似文献
998.
The liquid chromatographic enantiomer separation of N-fluorenylmethoxycarbonyl (FMOC) protected alpha-amino acids and their ethyl ester derivatives was performed on polysaccharide-derived chiral stationary phases, Chiralcel OD, Chiralpak AD, and Chiralpak AS. In general, Chiralcel OD and Chiralpak AD showed good performance for resolution of N-FMOC alpha-amino acids and their ethyl esters, respectively. All investigated N-FMOC alpha-amino acid enantiomers were baseline separated on Chiralcel OD or Chiralpak AD, whereas N-FMOC alpha-amino acid ethyl ester enantiomers were baseline resolved (alpha = 1.15-3.03) on Chiralpak AD, except for two analytes. The L-enantiomers of all examined FMOC alpha-amino acid ethyl ester derivatives are preferentially retained on Chiralpak AD, while the elution orders of the other enantiomer separations are not consistent. 相似文献
999.
Meyers CY Chan-Yu-King R Hua DH Kolb VM Matthews WS Parady TE Horii T Sandrock PB Hou Y Xie S 《The Journal of organic chemistry》2003,68(2):500-511
Most alkyl phenyl sulfones are readily alpha-chlorinated with CCl(4) and alpha-brominated with CBrCl3 in KOH-t-BuOH via radical-anion radical pair (RARP) reactions. While isopropyl mesityl sulfone (4) is easily alpha-chlorinated with CCl(4), it was completely recovered when treated with the more reactive CBrCl3. Subsequent investigations showed the latter result to be due to the poor acidity of 4 together with the rapid depletion of CBrCl3 and KOH by their reaction with each other, and led to a variety of other important results. 4-Hydroxyphenyl isopropyl sulfone (6) is unreactive with either CCl4 or CBrCl3 in KOH-t-BuOH, its phenoxide anion strongly reducing the electronegativity of the sulfonyl group, thereby inhibiting alpha-anion formation. This effect is reversed by the electron-withdrawing influence of two alpha-phenyls, so that benzhydryl 4-hydroxyphenyl sulfone (8) is readily alpha-halogenated in KOH-t-BuOH with CCl4 or CBrCl3. On further contact with KOH-t-BuOH the alpha-halogenated sulfones from 8 are decomposed into benzophenone and phenol. While the alpha-halogenated derivatives of 4-methoxyphenyl benzhydryl sulfone (9) are stable to base, they are decomposed even under mildly acidic conditions into 4-methoxyphenyl 4-methoxybenzenethiolsulfonate (9c), phenol, and benzophenone. Mono-alpha-halogenation of benzyl phenyl sulfone (10) enhances the rate of the subsequent halogenation, so that alpha,alpha-dihalogenation is attained while much substrate is still present and the mono-alpha-halogenated product is not detected. The ease of reductive debromination of alpha-bromo sulfones with Cl3C- was correlated with the stability of the formed alpha-anions, explaining the success with alpha-bromobenzylic sulfones but failure with alpha-bromoalkyl sulfones. In the presence of air and the absence of competing halogenation, formation of the alpha-anions of alkyl aryl sulfones is quickly accompanied by oxidative cleavage by atmospheric O2, leading to the formation of arenesulfonyl alcohols, arenesulfonyl halides, and haloarenes. 相似文献
1000.