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101.
Dr. A. Kaczyński Dr. S. J. Matysiak 《Archive of Applied Mechanics (Ingenieur Archiv)》1988,58(2):137-147
Summary This paper deals with the two-dimensional static punch problems in the presence of friction for a periodically layered half-space. Within the framework of the homogenized model of linear elasticity with microlocal parameters [8–11] the exact solutions of the considered problems are obtained. The case of the indentation of the composite body by a rigid rectangular punch has been discussed in detail.
Ebene Kontaktprobleme für ein periodisches elastisches Zweischichten-Komposit
Übersicht In dieser Arbeit wird das zweidimensionale statische Stempelproblem mit Reibung für einen periodisch geschichteten Halbraum betrachtet. Im Rahmen eines Homogenisierungsmodells der linearen Elastizitätstheorie mit mikropolaren Parametern werden die exakten Lösungen der betrachteten Probleme gewonnen. Im Detail wird das Eindringen eines rechteckigen starren Stempels behandelt.相似文献
102.
Dr. H. U. Buhl 《Mathematical Methods of Operations Research》1988,32(2):111-119
Contrary to the variety of models and procedures for optimizing the ordering decision in inventory control theory, no comparable tools exist for the scrapping decision. Thus, the current paper constitutes a step in this direction. Using a simple deterministic model, the basic economics and structure of the problem are introduced first. Then we determine explicitly scrap-optimal turn-around-times as well as the corresponding scrap- and rest-quantities. Accounting for the stochastic nature of demand, the model is generalized and algorithms for determination of optimal scrapping decision are discussed. Finally we compare the results and discuss practical applications. 相似文献
103.
104.
Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy. 总被引:3,自引:0,他引:3
Bärbel I. de Bakker Dr. Frank de Lange Dr. Alessandra Cambi Dr. Jeroen P. Korterik Erik M. H. P. van Dijk Dr. Niek F. van Hulst Prof. Carl G. Figdor Prof. Maria F. Garcia‐Parajo Prof. 《Chemphyschem》2007,8(10):1473-1480
DC-SIGN, a C-type lectin exclusively expressed on dendritic cells (DCs), plays an important role in pathogen recognition by binding with high affinity to a large variety of microorganisms. Recent experimental evidence points to a direct relation between the function of DC-SIGN as a viral receptor and its spatial arrangement on the plasma membrane. We have investigated the nanoscale organization of fluorescently labeled DC-SIGN on intact isolated DCs by means of near-field scanning optical microscopy (NSOM) combined with single-molecule detection. Fluorescence spots of different intensity and size have been directly visualized by optical means with a spatial resolution of less than 100 nm. Intensity- and size-distribution histograms of the DC-SIGN fluorescent spots confirm that approximately 80 % of the receptors are organized in nanosized domains randomly distributed on the cell membrane. Intensity-size correlation analysis revealed remarkable heterogeneity in the molecular packing density of the domains. Furthermore, we have mapped the intermolecular organization within a dense cluster by means of sequential NSOM imaging combined with discrete single-molecule photobleaching. In this way we have determined the spatial coordinates of 13 different individual dyes, with a localization accuracy of 6 nm. Our experimental observations are all consistent with an arrangement of DC-SIGN designed to maximize its chances of binding to a wide range of microorganisms. Our data also illustrate the potential of NSOM as an ultrasensitive, high-resolution technique to probe nanometer-scale organization of molecules on the cell membrane. 相似文献
105.
Doz. Dr. Karl Gewald Gudrun Heinhold 《Monatshefte für Chemie / Chemical Monthly》1976,107(6):1413-1421
The alkylation of arylaminomethylenecyanamides1 or cyano-imidothiocarbamates2 with -halogen carbonyl compounds followed by base catalysed cyclization yields substituted 4-amino-imidazoles4. Imidazo[4,5-d]pyrimidones5, 6 and imidazo[4,5-b]pyridines7 can be obtained from4. 相似文献
106.
Summary The electrocapillary properties of polyacrylic acid have been studied by two methods. Exploratory measurements have been made of the effect of the polymer on the differential capacity of a mercury drop in 0.1 m sodium perchlorate. They showed that the polymer was strongly adsorbed over a wide range of potentials but that it did not appear to form a monolayer. The surface excess of polymer obtained from drop weight data showed a maximum at very low concentrations and then a decline at higher concentrations. The bulk of the work was carried out by making surface tension measurements, using a sessile mercury drop, in solutions of a fraction of polyacrylic acid (mol. wt. 7.02×104) in potassium chloride at 0.01, 0.1, 0.2, and 0.5 m at 25°C.The data have been used to evaluate the surface excesses of the polymer and of the inorganic ions. The distribution of K+ and Cl– in the electrical double layer and the contact adsorption of Cl– on the mercury were very little affected by the presence of the polymer. The surface excess of polymer was always found to be greatest at low concentrations, to decrease steeply at first as the concentration was increased and then to decrease more slowly at higher concentrations.Possible explanations of this behaviour are discussed and it is concluded that the rapid decrease is a consequence of molecular weight dispersion and the stronger adsorption of high molecular weight polymer. The slow decrease in surface excess at higher concentrations may be a result of configurational changes of the polymer molecules.Surface pressure data show that, despite this decrease in the surface excess, the surface coverage reaches a high level at very low polymer concentrations and then continues to increase slowly as the concentration of polymer is increased. This apparent contradiction is due to changes in configuration of the adsorbed polymer molecules. At higher bulk concentrations the chain configurations are more compact and each adsorbed molecule makes more contacts with and so occupies a greater area of the mercury surface than at low concentrations.The conclusion is reached that the surface excess of polymer is mostly contained in a layer probably more than 1000 Å thick. It consists of a concentrated and entangled mass of polymer chains. Relatively few of these chains are in contact with the mercury at any istant. The concentration in this surface layer decreases steadily with increasing distance from the mercury surface and it merges without discontinuity into the bulk solution.With 10 figures in 22 details 相似文献
107.
108.
109.
An improved high-performance liquid chromatographic method for the simultaneous determination of caffeine and its N-demethylated metabolites in plasma is described. Excellent resolution of all components is provided by reversed-phase chromatography using a mobile phase consisting of 1% acetic acid-methanol (83:17) at a flow-rate of 2.7 ml/min, in conjunction with a Waters Assoc. Nova-Pak C18 column which was protected by a Waters Assoc. Guard-Pak precolumn module containing a Guard-Pak CN cartridge. Rapid extraction of caffeine and the dimethylxanthines from plasma was achieved using reversed-phase octadecylsilane bonded-silica columns (Bond-Elut C18). With only 100 microliters of sample, plasma levels in the region of 50 ng/ml for the dimethylxanthines and 100 ng/ml for caffeine can be determined using ultraviolet detection at 273 nm. The method has been used for measuring umbilical cord plasma samples to provide information regarding foetal exposure to caffeine and its metabolites and is also suitable for therapeutic drug monitoring of caffeine and theophylline levels in the treatment of neonatal apnoea. 相似文献
110.
Vladimir Rapić Prof. Dr. Karl Schlögl Brigitte Steinitz 《Monatshefte für Chemie / Chemical Monthly》1977,108(4):767-780
Starting from optically active methylferrocene-- and--carboxylic acids (1 a and1 b) of known absolute configuration and enantiomeric purity about 15 chiral ferrocenes (of each isomeric series— and ) were obtained by suitable ligand transformations. Thereby (almost) all possible chiral combinations of the ligands CH3, COOH (COO–), COOCH3, CN and NH2 (NH3
+) were accessible which are necessary for a potential test of approximations of chirality functions for compounds with basic symmetry C5v. The chiroptical properties of these disubstituted ferrocenes are recorded.Preliminary tests using a shortened Ansatz revealed large discrepancies between calculated () and found [M]D-values. Possible reasons for this failure are discussed.
61. Mitt. über Ferrocenderivate
39. Mitt.:A. Meyer, H. Neudeck undK. Schlögl, Chem. Ber.110, 1403 (1977).
60. Mitt.:V. Rapi, K. Schlögl undB. Steinitz, J. Organometal. Chem.94, 87 (1975). 相似文献
61. Mitt. über Ferrocenderivate
39. Mitt.:A. Meyer, H. Neudeck undK. Schlögl, Chem. Ber.110, 1403 (1977).
60. Mitt.:V. Rapi, K. Schlögl undB. Steinitz, J. Organometal. Chem.94, 87 (1975). 相似文献