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61.
62.
B Anuradha CM Santosh V Hari Sai Priya G Suman Latha KJR Murthy Valluri Vijaya Lakshmi 《Journal of immune based therapies and vaccines》2007,5(1):8-7
Background
Mycobacterium bovis BCG vaccine has displayed inconsistent efficacy in different trials conducted in various geographical regions. Nevertheless, it significantly reduces the risk of severe childhood tuberculosis and continues to be used to prevent tuberculosis in many countries. Many studies revealed that efficacy of vaccine wanes with age. Most of the studies were based on in vivo and in vitro responses to tuberculin. With the advent of newer tests such as in vitro interferon-γ assays and identification of potent immunogenic mycobacterial proteins there is a need to corroborate the observations. This study aims at ascertaining the need for a booster at a later age as indicated by in vitro release of IFN-γ while evaluating Ag85A as an antigen. 相似文献63.
D. Forthomme C. Linton A.G. Read D.W. Tokaryk A.G. Adam L.E. Downie A.D. Granger W.S. Hopkins 《Journal of Molecular Spectroscopy》2011,270(2):108-115
The bands of the A2E–X2A1 and B2A1–X2A1 electronic transitions of SrO12CH3 and the B2A1–X2A1 transition of SrO13CH3 have been recorded at high resolution using a laser ablation jet source. The optical–optical double resonance population depletion technique was used to facilitate the assignment of the spectra. Rotational levels with K = 0, ±1 in the X2A1 and B2A1 states and K = 0, 1 and 2 in the A2E state have all been characterised. A perturbation affecting the B2A1 state caused a reversal of the ordering of the spin-rotation components, F1 and F2, in the SrO12CH3 isotopologue. This required the introduction of a modified rotational constant Bmod, affecting only the K = 1, F2 component of the B2A1 state, in order to model the SrO12CH3 data in a global fit of the A2E–X2A1 and B2A1–X2A1 transitions. 相似文献
64.
Babajan Banaganapalli Chaitanya Mulakayala Gowsia D Naveen Mulakayala Madhusudana Pulaganti Noor Ahmad Shaik Anuradha CM Raja Mohan Rao Jumana Yousuf Al-Aama Suresh Kumar Chitta 《Applied biochemistry and biotechnology》2013,171(7):1639-1657
Resveratrol (RVS) is a naturally occurring antioxidant, able to display an array of biological activities. In the present investigation, a new derivative of RVS, RVS(a), was synthesized, and its biological activity was determined on U937 cells. It was observed that RVS(a) showed pronounced activity on U937 cells than RVS. RVS(a) is able to induce apoptosis in tumor cell lines through subsequent DNA fragmentation. From the EMSA results, it was evident that RVS(a) was able to suppress the activity of NFkB by interfering its DNA binding ability. Furthermore, the molecular interaction analysis (docking and dynamics) stated that RVS(a) has strong association with the IkB-alpha site of NFkB compared with RVS; this binding nature of RVS(a) might be prevent the NFkB binding ability with DNA. The present findings represent the potential activity of propynyl RVS on U937 cells and signifying it as a one of putative chemotherapeutic drugs against cancer. 相似文献