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排序方式: 共有125条查询结果,搜索用时 31 毫秒
91.
Stepp BR Gibbs-Davis JM Koh DL Nguyen ST 《Journal of the American Chemical Society》2008,130(30):9628-9629
Rigid small-molecule DNA hybrids (rSMDHs) have been synthesized with three DNA strands attached to a rigid tris(phenylacetylene) core. When combined under dilute conditions, complementary rSMDHs form cage dimers that melt at >10 degrees C higher and much sharper than either unmodified DNA duplexes or rSMDH aggregates formed at higher concentrations. With a 2.97 average number of cooperative duplexes, these caged dimers constitute the first example of cooperative melting in well-defined DNA-small-molecule structures, demonstrating the important roles that local geometry and ion concentration play in the hybridization/dehybridization of DNA-based materials. 相似文献
92.
Dr. Ribal Jabbour Dr. Christopher W. Ashling Thomas C. Robinson Dr. Arafat Hossain Khan Dr. Dorothea Wisser Dr. Pierrick Berruyer Dr. Ashta C. Ghosh Alisa Ranscht Dr. David A. Keen Prof. Dr. Eike Brunner Dr. Jérôme Canivet Prof. Dr. Thomas D. Bennett Dr. Caroline Mellot-Draznieks Dr. Anne Lesage Dr. Florian M. Wisser 《Angewandte Chemie (International ed. in English)》2023,62(44):e202310878
93.
J. W. Marden J. C. Ghosh H. T. Beans Dorothea R. Mossman J. Ciochina K. Roesch W. Werz H. Mathesius J. Arend H. Schnellenbach F. Spindeck A. Angeletti L. Moser K. Neumayer K. Winter J. Singer W. R. Schoeller C. Jahn H. W. Webb A. R. Powell H. Ginsberg F. P. Treadwell A. Gautier H. Hueber 《Analytical and bioanalytical chemistry》1933,93(5-6):203-222
94.
Dr. Anastasia Hager Dr. Mingxuan Wu Dr. Huanchen Wang Nathaniel W. Brown Jr. Prof. Stephen B. Shears Prof. Nicolás Veiga Prof. Dorothea Fiedler 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(35):12406-12414
The inositol pyrophosphate messengers (PP‐InsPs) are emerging as an important class of cellular regulators. These molecules have been linked to numerous biological processes, including insulin secretion and cancer cell migration, but how they trigger such a wide range of cellular responses has remained unanswered in many cases. Here, we show that the PP‐InsPs exhibit complex speciation behaviour and propose that a unique conformational switching mechanism could contribute to their multifunctional effects. We synthesised non‐hydrolysable bisphosphonate analogues and crystallised the analogues in complex with mammalian PPIP5K2 kinase. Subsequently, the bisphosphonate analogues were used to investigate the protonation sequence, metal‐coordination properties, and conformation in solution. Remarkably, the presence of potassium and magnesium ions enabled the analogues to adopt two different conformations near physiological pH. Understanding how the intrinsic chemical properties of the PP‐InsPs can contribute to their complex signalling outputs will be essential to elucidate their regulatory functions. 相似文献
95.
Dr. Mao Li Dr. Robert Puschmann Andreas Herdlitschka Prof. Dorothea Fiedler Prof. Helma Wennemers 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(36):15716-15719
Inositol hexakisphosphate (InsP6) is a central member of the inositol phosphate messengers in eukaryotic cells. Tools to manipulate the level of InsP6, particularly with compartment selectivity, are needed to enable functional cellular studies. We present cationic octa-(4S)guanidiniumproline ( Z8 ) for the delivery of InsP6 into the cell nucleus. CD spectroscopy, binding affinity, dynamic light scattering, and computational studies revealed that Z8 binds tightly to InsP6 and upon binding undergoes a conformational change from a PPII-helical structure to a structure that forms aggregates. The unique conformational features of the cationic oligoproline enable complex formation and cellular delivery of InsP6 with considerably greater efficacy than the flexible counterpart octaarginine. 相似文献
96.
Rare‐Earth‐Metal Methyl,Amide, and Imide Complexes Supported by a Superbulky Scorpionate Ligand
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Dorothea Schädle Dr. Cäcilia Maichle‐Mössmer Dr. Christoph Schädle Prof. Dr. Reiner Anwander 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(2):662-670
The reaction of monomeric [(TptBu,Me)LuMe2] (TptBu,Me=tris(3‐Me‐5‐tBu‐pyrazolyl)borate) with primary aliphatic amines H2NR (R=tBu, Ad=adamantyl) led to lutetium methyl primary amide complexes [(TptBu,Me)LuMe(NHR)], the solid‐state structures of which were determined by XRD analyses. The mixed methyl/tetramethylaluminate compounds [(TptBu,Me)LnMe({μ2‐Me}AlMe3)] (Ln=Y, Ho) reacted selectively and in high yield with H2NR, according to methane elimination, to afford heterobimetallic complexes: [(TptBu,Me)Ln({μ2‐Me}AlMe2)(μ2‐NR)] (Ln=Y, Ho). X‐ray structure analyses revealed that the monomeric alkylaluminum‐supported imide complexes were isostructural, featuring bridging methyl and imido ligands. Deeper insight into the fluxional behavior in solution was gained by 1H and 13C NMR spectroscopic studies at variable temperatures and 1H–89Y HSQC NMR spectroscopy. Treatment of [(TptBu,Me)LnMe(AlMe4)] with H2NtBu gave dimethyl compounds [(TptBu,Me)LnMe2] as minor side products for the mid‐sized metals yttrium and holmium and in high yield for the smaller lutetium. Preparative‐scale amounts of complexes [(TptBu,Me)LnMe2] (Ln=Y, Ho, Lu) were made accessible through aluminate cleavage of [(TptBu,Me)LnMe(AlMe4)] with N,N,N′,N′‐tetramethylethylenediamine (tmeda). The solid‐state structures of [(TptBu,Me)HoMe(AlMe4)] and [(TptBu,Me)HoMe2] were analyzed by XRD. 相似文献
97.
We study the Fictitious Play process with bounded and unbounded recall in pure coordination games for which failing to coordinate
yields a payoff of zero for both players. It is shown that every Fictitious Play player with bounded recall may fail to coordinate
against his own type. On the other hand, players with unbounded recall are shown to coordinate (almost surely) against their
own type as well as against players with bounded recall. In particular, this implies that a FP player's realized average utility
is (almost surely) at least as large as his minmax payoff in 2×2 coordination games.
Received: December 1997/Final version: November 1998 相似文献
98.
Ein Chitin‐MOF‐Kompositmaterial mit hierarchischem Porensystem für Anwendungen in der Luftfiltration
99.
Mao Li Robert Puschmann Andreas Herdlitschka Dorothea Fiedler Helma Wennemers 《Angewandte Chemie (International ed. in English)》2020,59(36):15586-15589
Inositol hexakisphosphate (InsP6) is a central member of the inositol phosphate messengers in eukaryotic cells. Tools to manipulate the level of InsP6, particularly with compartment selectivity, are needed to enable functional cellular studies. We present cationic octa‐(4S)guanidiniumproline ( Z8 ) for the delivery of InsP6 into the cell nucleus. CD spectroscopy, binding affinity, dynamic light scattering, and computational studies revealed that Z8 binds tightly to InsP6 and upon binding undergoes a conformational change from a PPII‐helical structure to a structure that forms aggregates. The unique conformational features of the cationic oligoproline enable complex formation and cellular delivery of InsP6 with considerably greater efficacy than the flexible counterpart octaarginine. 相似文献
100.
Biological Chitin–MOF Composites with Hierarchical Pore Systems for Air‐Filtration Applications
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Dorothea Wisser Florian M. Wisser Silvia Raschke Nicole Klein Matthias Leistner Julia Grothe Eike Brunner Stefan Kaskel 《Angewandte Chemie (International ed. in English)》2015,54(43):12588-12591
Metal–organic frameworks (MOFs) are promising materials for gas‐separation and air‐filtration applications. However, for these applications, MOF crystallites need to be incorporated in robust and manageable support materials. We used chitin‐based networks from a marine sponge as a non‐toxic, biodegradable, and low‐weight support material for MOF deposition. The structural properties of the material favor predominant nucleation of the MOF crystallites at the inside of the hollow fibers. This composite has a hierarchical pore system with surface areas up to 800 m2 g−1 and pore volumes of 3.6 cm3 g−1, allowing good transport kinetics and a very high loading of the active material. Ammonia break‐through experiments highlight the accessibility of the MOF crystallites and the adsorption potential of the composite indicating their high potential for filtration applications for toxic industrial gases. 相似文献